Clinical trials: Atrium; Flutter
Atrial Fibrillation, Atrial Flutter
Validation of a Novel Smartphone-based Method for Heart Rhythm Monitoring in the Home Environment
Atrial fibrillation is a heart rhythm disorder with increased risk of stroke, heart failure, dementia and death. The severity of symptoms in atrial fibrillation varies markedly, ranging from no symptoms to those with disabling…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Arrhythmia
- Trial name
- NCT04300270
- Testing
- Smartphone PPG recordings, Smartphone ECG
- Where
- Sweden
- Volunteers
- 480 people
- Sponsor
- Karolinska Institutet
Atrial Flutter Typical
Prophylactic Pulmonary Vein Isolation During Atrial Flutter Ablation
Pulmonary vein isolation (PVI) via catheter ablation has been successfully employed for years to treat symptomatic atrial fibrillation (AF).
- Trial name
- PREVENT-AF II (NCT07649603)
- Testing
- Catheter ablation
- Volunteers
- 620 people
- Sponsor
- University of Rochester
Atrial Flutter
Clinical Evaluation of the Blazer® Open-Irrigated Catheter for Treatment of Type 1 Atrial Flutter
The purpose of the BLOCk-CTI study is to evaluate the safety and effectiveness of the Blazer® Open-Irrigated Ablation Catheter for the treatment of sustained or recurrent type 1 atrial flutter.
- Trial name
- BLOCk-CTI (NCT01253200)
- Testing
- Blazer® Open-Irrigated Ablation Catheter, Control Catheter
- Where
- 26 sites in United States
- Volunteers
- 302 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation, Atrial Flutter
Impact of an Atrial Fibrillation Decision Support Tool (AFDST) on Thromboprophylaxis for Atrial Fibrillation
Study objective was to improve decision-making and thromboprophylaxis for patients with Atrial Fibrillation (AF) by developing and implementing a computerized decision support tool for individual patient-level decision-making…
- Trial name
- NCT02524977
- Testing
- Decision Support, Educational Intervention Only
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Thrombotic Stroke, Atrial Fibrillation and Flutter
ReAl-life Multicentre Survey Evaluating Stroke Prevention Strategies (RAMSES)
The aim of this study is to evaluate the present status of stroke prevention strategies in patients with non-valvular atrial fibrillation (NVAF).
- Trial name
- RAMSES (NCT02344901)
- Where
- 62 sites in Turkey (Türkiye)
- Volunteers
- 6,273 people
- Sponsor
- Muğla Sıtkı Koçman University
Atrial Fibrillation or Atrial Flutter, Thrombosis of Left Atrial Appendage
Resolution of Left Atrial-Appendage Thrombus - Effects of Dabigatran in Patients With AF
The primary objective of this study is to assess whether Dabigatran leads to a faster complete left atrial appendage (LAA) thrombus resolution as compared to Phenprocoumon.
- Trial name
- RE-LATED_AF (NCT02256683)
- Testing
- Dabigatran etexilate, Phenprocoumon
- Where
- 14 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Johannes Gutenberg University Mainz
Atrial Flutter With Rapid Ventricular Response
MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation
The purpose of this research study is to find out if the use of magnesium in addition to Metoprolol, a rate controlling medication that you would be offered in the Emergency Department today unrelated to this study, will help…
- Trial name
- MAGNETIC-AF (NCT07632157)
- Testing
- Magnesium Sulfate 2g, Magnesium Sulfate 4g, Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Wake Forest University Health Sciences
Intracranial Hemorrhages, Atrial Fibrillation (AF)
Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.
Atrial fibrillation is the most common cardiac arrhythmia. In atrial fibrillation, there is a risk that clots can form in the heart, especially in the left atrium. If these clots come loose, there is a risk of stroke.
- Conditions
- Intracranial Hemorrhages, Atrial Fibrillation (AF), Atrial Flutter
- Trial name
- CLEARANCE (NCT04298723)
- Testing
- Percutaneous closure of the LAA (Watchman / Watchman FLX)
- Where
- 39 sites in Germany, Poland
- Volunteers
- 530 people
- Sponsor
- Jena University Hospital
Cavotricuspid Isthmus Dependent Atrial Flutter
Pulsed Field Ablation for Cavotricuspid Isthmus Dependent Atrial Flutter Cohort Study
Pulsed field ablation (PFA) has been demonstrated to be safe and effective in achieving pulmonary vein isolation in patients with atrial fibrillation (AF). Coexisting atrial flutter is common in patients with AF.
- Trial name
- NCT07012460
- Testing
- CTI ablation
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Atrial Flutter
ICE Based Atrial Flutter Ablation Vs Conventional Fluoroscopy/Anatomical Mapping Based Ablation - ICE Flutter Study
Intracardiac echocardiography (ICE), has been an essential component of Radiofrequency (RF) ablations for AF given its association with decreased fluoroscopy time and complication rates, and therefore it is logical that this can…
- Trial name
- NCT05229848
- Testing
- 3D electroanatomical mapping alone guided CTI ablation, ICE plus 3D electroanatomical mapping guided CTI ablation
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Chronic Lymphocytic Leukemia (CLL), Waldenstr(SqrRoot)(Delta)m s Macroglobulinemia
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Background: Bruton s tyrosine kinase inhibitors (BTKi) are used to treat a form of leukemia. But taking BTKi can also increase a person s risk of developing an abnormal heart rhythm. This can cause sudden death.
- Conditions
- Chronic Lymphocytic Leukemia (CLL), Waldenstr(SqrRoot)(Delta)m s Macroglobulinemia, Mantle Cell Lymphoma, Sudden Cardiac Death
- Trial name
- NCT05724121
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation, Atrial Flutter
Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation
Primary objective of the PAPPHY Study is to establish the prevalence of primary aldosteronism (PA) in consecutive hypertensive patients referred for 'lone' paroxysmal, persistent or permanent atrial flutter or fibrillation (AFF).
- Conditions
- Atrial Fibrillation, Atrial Flutter, Aldosteronism
- Trial name
- PAPPHY (NCT01267747)
- Where
- 2 sites in Italy
- Volunteers
- 411 people
- Sponsor
- University Hospital Padova
Atrial Flutter
The Contact-CTI Study: Use of Tissue Contact Data to Guide Atrial Flutter Ablation
This study will be a single blind prospective randomised control trial in patients undergoing ablation for the treatment of typical atrial flutter, with the aim of investigating the benefit of a new impedance-based computer…
- Trial name
- NCT01596959
- Testing
- Radiofrequency ablation utilising the ECI contact software, Radiofrequency ablation without the use of ECI contact data
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- Oxford University Hospitals NHS Trust
Atrial Fibrillation, Atrial Flutter
Acute Atrial Fibrillation and Flutter Treated Electively
The AFFELECT -study compares two types of treatment modalities for acute atrial fibrillation or flutter for patients in whom rhythm control is desirable.
- Trial name
- AFFELECT (NCT04267159)
- Testing
- Acute cardioversion, Delayed cardioversion
- Where
- 4 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University
Atrial Fibrillation, Arrhythmias, Cardiac
Apple Heart Study: Assessment of Wristwatch-Based Photoplethysmography to Identify Cardiac Arrhythmias
The Apple Heart Study (AHS) is a research study conducted to evaluate whether the Apple Heart Study App can use data collected on the Apple Watch to identify irregular heart rhythms, including those from potentially serious heart…
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Atrial Flutter
- Trial name
- NCT03335800
- Testing
- Apple Heart Study App
- Where
- United States
- Volunteers
- 419,927 people, healthy volunteers welcome
- Sponsor
- Apple Inc.
Atrial Flutter
Maximum Targeted Ablation of Atrial Flutter
Patients undergoing atrial flutter ablation will be randomized to either the standard ablation approach or voltage targeted approach. Patients will be followed for one year to assess outcome of the ablation technique
- Trial name
- NCT00491010
- Testing
- radiofrequency catheter ablation
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Atrial Fibrillation, Atrial Flutter
Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)
The prevention of perioperative atrial fibrillation (AF) and myocardial injury after non-cardiac surgery (MINS) has the potential to reduce mortality, stroke, and hospital stays in patients undergoing major thoracic surgery.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Myocardial Injury After Non-Cardiac Surgery
- Trial name
- COP-AF (NCT03310125)
- Testing
- Active Colchicine
- Where
- 46 sites in United States, Austria and 9 more
- Volunteers
- 3,209 people
- Sponsor
- Population Health Research Institute
Current or Recent History of Atrial Fibrillation
Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure
This study is being done to compare the effects of bucindolol hydrochloride (bucindolol) to metoprolol succinate (Toprol-XL) on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who…
- Trial name
- GENETIC-AF (NCT01970501)
- Testing
- bucindolol hydrochloride, metoprolol succinate
- Where
- 97 sites in United States, Canada and 4 more
- Volunteers
- 267 people
- Sponsor
- ARCA Biopharma, Inc.
Atrial Flutter
Cardiovascular Magnetic Resonance-Guided Radiofrequency-Ablation for Atrial Flutter
The purpose of this clinical study is to evaluate the and performance of the Imricor Medical Systems, Inc. (Imricor) MR Ablation Catheter when used with related accessories for the treatment of type I atrial flutter.
- Trial name
- NCT02699034
- Testing
- ablation for typical atrial flutter, Vision-MR ablation catheter
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- University of Leipzig
Atrial Flutter
A Phase II/III Tolerance and Efficacy Study of RSD1235 in Patients With Atrial Flutter
This study will attempt to demonstrate the effectiveness of RSD1235 in the conversion of atrial flutter (AFL) to sinus rhythm.
- Trial name
- Scene 2 (NCT00476112)
- Testing
- Vernakalant Injection 20 mg/mL
- Where
- 24 sites in United States, Canada and 2 more
- Volunteers
- 60 people
- Sponsor
- Advanz Pharma