Clinical trials: Auricular Vagus Nerve Stimulation
Obesity
Comparison of Different Weight Loss Methods in Obese Individuals
Although obesity is a rapidly increasing epidemic worldwide, it is associated with many health-related comorbidities. As a result of the developments in social life and observes the sedentary life in individuals, an effect of the…
- Trial name
- NCT05511376
- Testing
- AURICULAR VAGUS NERVE STIMULATION, DIET, EXERCISE
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Autonomic Nervous System Imbalance
Comparison of Transcutaneous Auricular Vagus and Trigeminal Nerve Stimulation
The aim of this study was to compare the results between transcutaneous auricular vagus nerve stimulation and trigeminal nerve stimulation with the results obtained from heart rate variability, pulse and blood pressure…
- Trial name
- NCT06730165
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Transcutaneous Auricular Trigeminal Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Modulation of Cardiovascular Parameters and Sympathovagal Balance in Healthy Subjects
Pilot Study - Auricular Vagus Nerve Stimulation Effects on Cardiovascular Parameters
The purpose of this pilot study is to evaluate the effect of auricular autonomous nervous system stimulation on cardiovascular parameters and sympathovagal balance in healthy subjects.
- Trial name
- NCT02139293
- Testing
- PrimeStim
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Stroke Patients
Effect of Transcutaneous Auricular Stimulation of the Vagus Nerve on Functional Connectivity in the Brain at Rest
The goal of this clinical trial is to study the effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on resting-state brain functional connectivity.
- Trial name
- COVAGNIRS (NCT07282106)
- Testing
- Active taVNS arm
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Clinique Les Trois Soleils
Healthy
The Effects of taVNS on Inhibitory Control
The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.
- Trial name
- NCT05468385
- Testing
- Vagus nerve stimulation via tragus
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Stroke, Hemiparesis
Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke
To determine whether treatment with transauricular vagus nerve stimulation (taVNS) during the training of an affected upper limb of a patient with chronic stroke on a robotic motor task alters the motor impairment.
- Trial name
- VaNSaRTS (NCT05339893)
- Testing
- In Motion Rehabilitation Robot
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy, Activity, Motor
The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters
OBJECTIVE: The aim of this study is to investigate the effect of non-invasive auricular VNS (Vagus Nerve Stimulation) on sportive performance and physiological parameters in healthy individuals.
- Trial name
- VNS001 (NCT04768738)
- Testing
- Auricular Vagus Nerve Stimulation Level Of Above Threshold, Auricular Vagus Nerve Stimulation Level Of Subthreshold, 5 Minutes Bicycle Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Sinop University
Parkinson Disease
The Effect and Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation on Gait Impairments in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients .
- Trial name
- NCT05561348
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Depression
Neural Alteration Response to Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Depressed Patients
Electrical vagus nerve stimulation (VNS) was approved by FDA for treatment of chronic recurrent depression in 2005. Recently, non-invasive, transcutaneous auricular vagus nerve stimulation （taVNS） has already been used for…
- Trial name
- NCT03592446
- Testing
- Transcutaneous electrical vagus nerve stimulation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xidian University
Anxiety, Distress, Emotional
Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers
The purpose of this research is to measure alterations in anxiety and brain activity associated with the use of an approved health device called Transauricular Vagal Nerve Stimulation (TaVNS) in distressed persons who work in a…
- Conditions
- Anxiety, Distress, Emotional, Effects of Vibration, Healthy
- Trial name
- fMRIVNS (NCT05132881)
- Testing
- Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS), Waitlist Control, Healthy Controls: Substudy Group III
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy Volunteers
Non-Invasive Transcutaneous Auricular Vagus Nerve Stimulation Applied at Different Durations in Healthy Adults
This randomized, participant-blinded, sham-controlled interventional study aims to compare the acute effects of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) applied at different durations on autonomic…
- Trial name
- taVNS-DUR (NCT07532005)
- Testing
- Active taVNS
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Sinop University
Opioid-use Disorder, Opioid Withdrawal
Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal
The objective of this study is to evaluate whether tAN via the tragus (vagal) and auriculotemporal (trigeminal) nerve pathways results in a clinically meaningful reduction in opioid withdrawal symptoms.
- Trial name
- NCT04731935
- Testing
- Sparrow Therapy System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Spark Biomedical, Inc.
Parkinson Disease
Research on the Brain Mechanism of taVNS in Regulating PD Motor Symptoms
This study is a double blind comparative study exploring the neural underpinnings of taVNS modulating PD motor deficits. We hypothesize that taVNS might improve PD motor deficits by regulating the balance between excitation and…
- Trial name
- NCT06409338
- Testing
- Transcutaneous auricular vagus nerve stimulation (active）
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Myocardial Injury
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Myocardial Injury in Elderly Patients Undergoing Thoracoscopic Surgery: a Prospective, Randomized Controlled Study
This research group plans to design a prospective, double-blind, randomized controlled study to explore the effect of taVNS on hs-cTnT in elderly patients undergoing thoracoscopic surgery, and to evaluate the effect on…
- Trial name
- NCT06759818
- Testing
- transcutaneous vagus nerve stimulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Jiaxing University
Healthy Volunteers
Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation in Healthy Individuals
This randomized, participant-blinded, sham-controlled crossover study aims to investigate the acute effects of different frequency applications of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic…
- Trial name
- taVNS-FREQ (NCT07526402)
- Testing
- taVNS 10 Hz, taVNS 25 Hz, taVNS 50 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sinop University
Healthy Volunteers
Using a Transcutaneous Electrical Auricular Stimulator to Harness the Cholinergic Anti-Inflammatory Pathway
Persistent chronic inflammation is an important underlying event in multiple diseases including rheumatoid arthritis, inflammatory bowel diseases and type 2 diabetes.
- Trial name
- TEACAP (NCT02910973)
- Testing
- Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Cognition, Healthy Volunteers
Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognition, Dual-Task Performance, and Interoceptive Accuracy
This study aims to determine the simultaneous effects of transcutaneous auricular vagus nerve stimulation (taVNS) at two frequencies (30 Hz and 100 Hz) compared to sham stimulation on cognitive functions, dual-task performance…
- Trial name
- NCT07897175
- Testing
- taVNS 30 Hz, taVNS 100 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Toros University
Class I Obesity
Trial of Innovative Fat-loss Focused Approaches in Patients With Class I Obesity: a Comparative Study
This single-center randomized comparative study is designed to compare the effectiveness of tirzepatide and transcutaneous low-frequency auricular vagus nerve stimulation in adults with class I obesity and without chronic…
- Trial name
- TIFFANY (NCT07866183)
- Testing
- Tirzepatide, Transcutaneous auricular vagus nerve stimulation
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Auricular Stimulation
Mastoid taVNS-fMRI
The purpose of this study is to explore whether stimulating different outer parts of the ear using a non-invasive form of ear stimulation called transcutaneous auricular vagus nerve stimulation (taVNS) will create different brain…
- Trial name
- NCT06518356
- Testing
- Transcutaneous Auricular Neurostimulation (tAN)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina