Clinical trials: Autofluorescence
Macrosomia, Fetal, Gestational Diabetes Mellitus in Pregnancy
New Markers of Glycation to Predict Gestational Diabetes Mellitus and Macrosomia.
Gestational diabetes mellitus (GDM) increases the risk of macrosomia and other adverse pregnancy outcomes. Screening strategies are debated: universal vs.
- Trial name
- GLYCAGEST (NCT06048510)
- Testing
- Pregnant women
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Bordeaux
Sickle Cell Disease
Spectralis HRA+OCT Imaging of the Retina With Autofluorescence in Sickle Cell Disease
To determine the retinal and choroidal thickness in patients with sickle cell disease compared to age, race matched population without sickle cell disease to allow a better understanding of the clinical manifestations of sickle…
- Trial name
- NCT01123369
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parathyroid Diseases, Parathyroid Dysfunction
Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy
The goal of this study is to assess whether using PTeye (AiBiomed, Santa Barbara, CA) - a NIRAF detection modality - can improve patient outcomes and reduce healthcare associated costs after parathyroid surgeries.
- Conditions
- Parathyroid Diseases, Parathyroid Dysfunction, Parathyroid Neoplasms, Parathyroid Adenoma
- Trial name
- NCT05152927
- Testing
- Parathyroid Eye (PTeye)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of California, San Francisco
Autofluorescence, Thyroidectomy
Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions
Hypoparathyroidism is the most frequent complication in total thyroidectomy. The use of near-infrared autofluorescence (NIRAF) intraoperatively, seems to reduce the rate of transient hypoparathyroidism.
- Conditions
- Autofluorescence, Thyroidectomy, Hypoparathyroidism, Hypocalcemia
- Trial name
- NCT05043584
- Testing
- Fluobeam LX, Fluoptics, Grenoble, France
- Where
- 2 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Regional Hospital West Jutland
Gastroesophageal Reflux Disease
Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease
Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI)…
- Trial name
- NCT01504971
- Testing
- symptom questionaire, pH monitoring, Tri-modal imaging endoscopy
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Chronic Kidney Disease
Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
The purpose of the present study is to investigate the association between the accumulation of advanced glycation end-products (AGE) and adverse outcomes (e.g.
- Trial name
- AGED (NCT02878317)
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Nottingham
Epiretinal Membrane
Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane
Fundus autofluorescence (FAF) at the macula originates from hyperfluorescence from retinal pigment epithelium (RPE) and blockage of hyperfluorescence by macular pigment.
- Trial name
- NCT02628158
- Testing
- Vitrectomy with internal limiting membrane removal
- Where
- Japan
- Volunteers
- 91 people
- Sponsor
- Kyorin University
Thyroid Disease, Hypoparathyroidism Postprocedural
Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Thyroidectomy
Hypoparathyroidism (and the resulting hypocalcemia) remains the most common morbidity after a total thyroidectomy. The identification and preservation of parathyroid glands during neck surgery has always been challenging but is…
- Trial name
- NCT05117853
- Testing
- Autofluorescent detection + Injection of indocyanine green, Gold standard of visual identification and evaluation of viability of the parathyroid glands.
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Onze Lieve Vrouw Hospital
Thyroid Surgery, Inadvertent Parathyroidectomy
Use of the PTEye Device to Reduce Inadvertent Parathyroidectomy During Thyroid Surgery
Inadvertent Parathyroidectomy (IP) during thyroid surgery may lead to transient or permanent hypoparathyroidism and hypocalcemia, which represents significant morbidity.
- Conditions
- Thyroid Surgery, Inadvertent Parathyroidectomy, Enlarged Thyroid
- Trial name
- NCT06927245
- Testing
- PTeye Device
- Volunteers
- 25 people
- Sponsor
- ProMedica Health System
Hypocalcemia
Clinical Impact of Parathyroid Autofluorescence Visualization During Thyroid Surgery
This Before-and-after Controlled Study study evaluates the clinical impact of parathyroid autofluorescence visualization using near infrared light (NIR) during total thyroidectomy (TT).
- Trial name
- NCT02889952
- Testing
- Near infrared camera (NIR)
- Volunteers
- 297 people
- Sponsor
- Hôpital Européen Marseille
Geographic Atrophy, Age-Related Macular Degeneration
OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration
Othera Pharmaceuticals' Othera (OT)-551 antioxidant eye drop has the potential for chronic treatment of the dry form of age-related macular degeneration.
- Conditions
- Geographic Atrophy, Age-Related Macular Degeneration, AMD
- Trial name
- NCT00306488
- Testing
- OT-551 antioxidant eye drop
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Non-Small-Cell Lung Carcinoma, Head and Neck Squamous Cell Cancer
LIFE-Lung Bronchoscopy in Patients at Risk for Developing Lung Cancer
The purpose of the study is to evaluate the usefulness and accuracy of the "LIFE-Lung Bronchoscopy" to identify early changes in lung tissues that show precancerous, cancer in situ (just beginning and not spread) and microscopic…
- Conditions
- Non-Small-Cell Lung Carcinoma, Head and Neck Squamous Cell Cancer, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00260598
- Testing
- LIFE Bronchoscopy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pittsburgh
Age-related Macular Degeneration
Fundus Autofluorescence Imaging in Age-related Macular Degeneration Using Confocal Scanning Laser Ophthalmoscopy
The purpose of this study is to define phenotypic variations in atrophic Age-Related Macular Degeneration (AMD) and to identify predictive factors for disease progression based on fundus autofluorescence imaging.
- Trial name
- NCT00393692
- Where
- 7 sites in Germany
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Diabetic Patients With/Without Atherosclerotic Diseases
Cardiovascular Risk Assesment in Diabetic Patients Via Lens Autofluorecscence Detection
The rate of lens autofluorescence will be compared in diabetic and non diabetic patients with/without atherosclerotic vascular diseases to evaluate if it is associated with the risk of cardiovascular diseases.
- Trial name
- CRADILA (NCT02947555)
- Testing
- Non interventional
- Where
- Hungary
- Volunteers
- 420 people
- Sponsor
- Dr. Gergő Molnár
Laryngeal Neoplasms
Characterization of the Autofluorescence of Healthy and Pathological Tissues of Vocal Cords
The aim of this clinical trial is to provide information about autofluorescence of pathological versus healthy vocal folds tissues.
- Trial name
- FLUOROCORD (NCT03585075)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer
Intraoperative Imaging of Lymph Nodes
One-third of the global population battles cancer, with surgery being the primary treatment for localized forms. Successful treatment often hinges on the thorough removal of primary tumors and pinpointing cancerous sentinel lymph…
- Trial name
- NCT06276439
- Testing
- Surgical removal of breast cancer and lymph nodes
- Where
- North Macedonia
- Volunteers
- 48 people
- Sponsor
- University of Illinois at Urbana-Champaign
Primary Hyperparathyroidism Due to Adenoma
Near Infrared Autofluorescence Imaging in Minimally-Invasive Video-Assisted Parathyroidectomy (NIRAF MIVAP Study)
The role of near-infrared autofluorescence (NIRAF)-imaging as an adjunct in thyroid surgery is well established. However, its diagnostic role in hyperparathyroidism surgery is yet to be defined due to the lack of consensus…
- Trial name
- NIRAF MIVAP (NCT06779760)
- Testing
- parathyroidectomy
- Where
- Jordan
- Volunteers
- 24 people
- Sponsor
- Aristotle University Of Thessaloniki
Central Serous Chorioretinopathy
Micropulse Diode Laser Treatment for Chronic Central Serous Chorioretinopathy
The aim of this study was to evaluate safety and therapeutic response to micropulse diode 810nm laser treatment in patients with chronic central serous chorioretinopathy.
- Trial name
- NCT01327170
- Testing
- Subthreshold diode micropulse laser
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of São Paulo
Hyperparathyroidism, Primary
Autofluorescence in Surgery for Primary Hyperparathyroidism
The study aims to test if autofluorescence imaging (AF) is a useful surgical aid during parathyroidectomy (PTX) for primary hyperthyroidism (PHPT).
- Trial name
- NCT06230380
- Testing
- Surgery with autofluorescence
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Uveitis, Macular Edema
Autofluorescence in Uveitic and Diabetic Macular Edema
The aim of this study is to determine whether fundus autofluorescence and macular pigment distribution in inflammatory and diabetic macular edema are altered.
- Trial name
- NCT00956124
- Where
- Germany
- Sponsor
- St. Franziskus Hospital