Clinical trials: Autoimmune Bullous Dermatosis
Bullous Pemphigoid (BP)
Study of Stapokibart Injection in Subjects With Moderate to Severe Bullous Pemphigoid
This study is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study to evaluate the efficacy, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of Stapokibart in subjects with Moderate…
- Trial name
- NCT07210554
- Testing
- Stapokibart injection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chengdu Kangnuoxing Biopharma,Inc.
Bullous Dermatoses, Psoriasis
Intradermal Tozinameran for Patients With Immune-mediated Dermatologic Diseases
This is a randomised controlled trial conducted to prove that the immunological performance of intradermal tozinameran (i.e., Pfizer-BioNTech COVID-19 vaccine) is no worse than the standard intramuscular route in patients with…
- Conditions
- Bullous Dermatoses, Psoriasis, COVID-19 Vaccines
- Trial name
- NCT05406908
- Testing
- tozinameran
- Where
- Thailand
- Volunteers
- 109 people
- Sponsor
- Mahidol University
Bullous Pemphigoid
Azathioprine or Mycophenolate Mofetil for Bullous Pemphigoid
To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid.
- Trial name
- NCT00431119
- Testing
- Azathioprine or Mycophenolate mofetil
- Where
- 11 sites in Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital Muenster
Periodontal Diseases, Psoriasis
Periodontal Status in Patients With Chronic Skin Diseases
Objective: This study aimed to evaluate and compare the periodontal status of chronic skin disease (CSD) patients with healthy controls. Material and method: 109 patients and 37 healthy subjects were included in this study.
- Conditions
- Periodontal Diseases, Psoriasis, Atopic Dermatitis, Autoimmune Bullous Dermatosis
- Trial name
- NCT06073613
- Testing
- oral health status
- Where
- Vietnam
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Pemphigoid, Bullous
The Effects of Tildrakizumab in Treatment of Bullous Pemphigoid
This is an open-label, pilot study evaluating the efficacy of tildrakizumab on the treatment of bullous pemphigoid (BP) in eligible patients (see detailed study protocol).
- Trial name
- NCT04465292
- Testing
- Tildrakizumab Prefilled Syringe
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Bullous Pemphigoid
A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid
The main purpose of this study is to investigate whether dupilumab is effective and safe for the treatment of bullous pemphigoid. Dupilumab is a type of drug called a "monoclonal antibody".
- Trial name
- LIBERTY-BP (NCT04206553)
- Testing
- dupilumab, Oral corticosteroids (OCS)
- Where
- 53 sites in United States, Australia and 7 more
- Volunteers
- 106 people
- Sponsor
- Regeneron Pharmaceuticals
Bullous Pemphigoid
Treatment of Bullous Pemphigoid With Avdoralimab (IPH5401), an Anti-C5aR1 Monoclonal Antibody
The development of Auto Immune bullous Diseases (AIBD) results from a complex interaction between innate and adaptive immune systems.
- Trial name
- IPH (NCT04563923)
- Testing
- Avdoralimab (IPH5401), Control
- Where
- 4 sites in France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pemphigus
Hematopoietic Stem Cell Support in Patients With Autoimmune Bullous Skin Disorders
Autoimmune Bullous Skin Disorders are believed to be due to immune cells, cells that normally protect the body and are now causing damage to the body.
- Trial name
- NCT00278642
- Testing
- Hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Richard Burt, MD
Pemphigoid, Bullous, Pemphigus
Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid
The primary objective of this study is to describe and compare plasmatic anti-proteasome auto-antibody concentrations among three distinct groups: (1) patients suffering from bullous pemphigoide; (2) patients suffering from other…
- Conditions
- Pemphigoid, Bullous, Pemphigus, Lupus Erythematosus, Cutaneous
- Trial name
- NCT01559155
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bullous Pemphigoid
Topical Steroids Alone or Associated With Methotrexate in Bullous Pemphigoid
This controlled multi-center randomized clinical trial, with direct individual benefit, will compare efficacy and safety of two strategies in non-localized BP care: a combined regimen using initial superpotent topical steroids…
- Trial name
- BP/MTX (NCT02313870)
- Testing
- clobetasol propionate + Methotrexate, clobetasol propionate alone
- Where
- France
- Volunteers
- 322 people
- Sponsor
- University Hospital, Montpellier
Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue, Pyoderma Gangrenosum
Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
This study investigates the genetic architecture of Neutrophil-Mediated Inflammatory Skin Diseases. After collecting informed consent, all patients' clinical phenotype is graded at inclusion with a detailed case report form and a…
- Conditions
- Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue, Pyoderma Gangrenosum, Erosive Pustular Dermatosis of the Scalp, Sweet's Syndrome
- Trial name
- NEUTROGENE (NCT01952275)
- Testing
- Collection of biological samples
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University of Zurich
Pemphigoid, Bullous
Anti-IL-5 Therapy in Bullous Pemphigoid (BP)
Randomized, placebo-controlled, double-blind study evaluating the effect of anti-IL-5-therapy in patients with bullous pemphigoid.
- Trial name
- NCT01705795
- Testing
- Mepolizumab (a-IL-5 antibody)
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pemphigoid, Pruritus
Pruritus and Pemphigoid in Nursing Home Patients
The primary objective of this observational study is to describe the prevalence of pruritus and pemphigoid in nursing home patients.
- Trial name
- SSENIOR (NCT02823067)
- Testing
- Blood sample
- Where
- Netherlands
- Volunteers
- 125 people
- Sponsor
- M.F. Jonkman
Pemphigoid, Bullous
A Study to Assess the Therapeutic Effect and Safety of Adjunctive AKST4290 in Subjects With Bullous Pemphigoid
This study will evaluate the therapeutic effect and safety of adjunctive AKST4290 in subjects with bullous pemphigoid (BP).
- Trial name
- NCT04499235
- Testing
- Mometasone furoate, AKST4290
- Where
- 8 sites in Germany
- Volunteers
- 6 people
- Sponsor
- Alkahest, Inc.