Clinical trials: Autoimmune Connective Tissue Disorder
Rheumatoid Arthritis
Study of Venous Endothelial Cells in Rheumatoid Arthritis
Heart disease is the major contributor of early death in rheumatoid arthritis (RA) and is not influenced by traditional risk factors.
- Trial name
- NCT02468986
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sjogren's Syndrome
Sjogrens Syndrome Measured by Ultrasound
Ultrasound study focused on salivary gland outcomes in Sjogren's subjects
- Trial name
- NCT03411850
- Testing
- Orencia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arthritis & Rheumatism Associates, P.C.
Rheumatoid Arthritis, Healthy Control
Core Endurance, Finger Grip Strength, Fatigue, and Hand Function in Patients With Rheumatoid Arthritis
This study investigated the relationships between core endurance, finger grip strength, fatigue, and hand function in patients with rheumatoid arthritis.
- Trial name
- NCT07360496
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Rheumatoid Arthritis
RHYTHM (Formerly Escape II Myocardium)
For aim 1, the proposed studies will be performed in 150 patients with RA and 25 subjects without RA (healthy volunteers) who will function as controls.
- Trial name
- RHYTHM (NCT01548768)
- Testing
- TNF inhibitors, DMARDs
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Columbia University
Rheumatoid Arthritis, Rheumatoid Arthritis RA
Use of Thermography for the Prevention and Diagnosis of Rheumatic Foot
The aim of this observational study is to establish normal thermographic parameters in patients with rheumatoid arthritis, in order to prevent and diagnose rheumatic foot using thermography.
- Conditions
- Rheumatoid Arthritis, Rheumatoid Arthritis RA, Rheumatic Diseases
- Trial name
- TG-AR (NCT06515769)
- Testing
- TERMOGRAPHY
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Seville
Autoimmune Diseases, Systemic Inflammatory Process
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is a randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish…
- Conditions
- Autoimmune Diseases, Systemic Inflammatory Process, Knee Pain Chronic, Osteoarthritis
- Trial name
- VITAL (NCT01351805)
- Testing
- Fish Oil, Vitamin D
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis
Comparison the Safety and Pharmacokinetic Characteristics of DWP422 25 mg With Those of ENBREL 25MG PFS INJ. After Subcutaneous Injection in Healthy Male Volunteers
The purpose of this study was to compare the safety and pharmacokinetic characteristics of DWP422 25 mg with those of ENBREL 25MG PFS INJ. after subcutaneous injection in healthy male volunteers.
- Trial name
- NCT01635686
- Testing
- DWP422 25mg, ENBREL 25MG PFS INJ.
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
RheumatoId Arthritis
Metabolome Analysis in Patients With Rheumatoid Arthritis
The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals.
- Trial name
- NCT02960958
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Systemic Lupus Erythematosus
IL17 in Systemic Lupus Erythematosus Patients: Association With Disease Activity and Organ Damage
Many laboratory markers can be measured for assessment of Lupus activity as aberrant manufacturing and imbalance of the cytokines of T-helper cell which already have been implicated within autoimmunity pathogenesis as IL-18 and…
- Trial name
- NCT05045417
- Testing
- Serum level of IL-17
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sohag University
Rheumatoid Arthritis, Healthy Controls
Subunit Vaccine Against Herpes Zoster in RA Patients Treated With JAK-inhibitors (VACCIMIL-ZOSTER)
Background. A new subunit vaccine against herpes zoster (HZ) has recently been approved for vaccination of adults i in Sweden. This vaccine (Shingrix) elicits a strong cellular and humoral immune response in healthy adults…
- Trial name
- NCT03886038
- Testing
- Shingrix
- Where
- Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Region Skane
Arthritis, Rheumatoid, Bone Erosion
Identification of Novel Molecular Targets for Rheumatoid Arthritis Patients
Aims of this study is to identify the mechanisms of the dissociation between the inflammatory activity and the joints destruction in patients with rheumatoid arthritis (RA) in remission but presenting a progression of the bone…
- Trial name
- NCT04201535
- Testing
- Protein arrays on plasma samples
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Rheumatoid Arthritis
Feasibility of a Cytokine Expression Profile in Immune Cells as an Orientation Tool in Therapeutic Decisions for Auto-inflammatory and Auto-immune Diseases
This study will assess the feasibility of using cytokine expression profiles in blood samples as a method for evaluating rheumatoid polyarthritis
- Trial name
- IL-MAI (NCT03280797)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Lupus Nephritis, Lupus Erythematosus, Systemic
Establishing Clinical Utility of a New Diagnostic Test for Rheumatology Patients
This study will collect high-quality randomized controlled data from a nationally representative sample of practicing rheumatologists to determine how they currently manage patients with SLE (systemic lupus erythematosus) and how…
- Trial name
- NCT04266860
- Testing
- Experimental - Test Results and Education
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Dry Eye Syndrome, Sjogren's Syndrome
VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome
To evaluate the Chinese herbal tea VGH-DESJS-1 in ocular and oral dryness symptoms of Dry eye syndrome and Sjögren's syndrome
- Conditions
- Dry Eye Syndrome, Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT05656196
- Testing
- Chinese herbal tea VGH-DESJS-1
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Rheumatoid Arthritis (RA)
Pharmacokinetics, Safety and Tolerability Study of Single Dose of Abatacept 125mg Administered Subcutaneously
The objective of the study is to assess the single dose PK, safety, tolerability and immunogenicity of abatacept 125mg administered SC in Chinese healthy subjects.
- Trial name
- NCT02805010
- Testing
- Abatacept
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Pemphigus
Coagulation Activation in Patients With Pemphigus
Aim of work: 1. To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls. 2.
- Trial name
- NCT06285435
- Testing
- prothrombin fragment 1+2
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Volunteers
A Double-blind, Placebo-controlled, Single-dose Study to Evaluate the PK, IM, and Safety in Japanese Subjects
A phase 1 randomized, double blind single-dose study to evaluate the PK and immunogenicity of single SC 100 and 150 mg doses of mavrilimumab in healthy adult Japanese subjects.
- Trial name
- NCT02213315
- Testing
- 100mg Mavrilimumab, 150mg mavrilimumab
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Arthritis, Rheumatoid, Syndrome, Metabolic
An Exploratory Clinical Study on Autophagy During Fasting
Autophagy is considered one of the key molecular mechanisms for the broad preventive and therapeutic effects of periodic fasting.
- Conditions
- Arthritis, Rheumatoid, Syndrome, Metabolic, Healthy
- Trial name
- NCT04739852
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Vitiligo Vulgaris
Online Health Survey of Patients With Vitiligo Vulgaris/ Online Survey of Pediatric Patients With Vitiligo
The study is an on-line survey posted on survey monkey that addresses some demographic and environmental issues that could potentially relate to vitiligo vulgaris onset or disease exacerbation.
- Trial name
- NCT01401374
- Where
- United States
- Volunteers
- 3,258 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Horton's Disease
Study of the T CD8 Immune Response in Horton's Disease
The research hypothesis is that T lymphocytes CD8 play a role in the physiopathology of Horton's disease. At the inclusion visit, patients will have, as is the case in the usual strategy: A complete clinical examination carried…
- Trial name
- Horton CD8 (NCT02158208)
- Testing
- Blood sample drawn into a 5 mL dry tube at the diagnosis and after 3 months of treatment, 16 blood samples drawn into 6 mL heparinized tubes at the diagnosis and after 3 months of treatment, Blood sample drawn into a 5 mL dry tube
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon