Clinical trials: Autoimmune Disorder
Myasthenia Gravis
Sensitivity of Repetitive Nerve Stimulation Performed in the Evening vs in the Morning in Myasthenia Gravis
Myasthenia gravis (MG) is the autoimmune disorder affecting the neuromuscular junction, characterized by fatigue, which increases gradually through the day.
- Trial name
- NCT05337891
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Jagiellonian University
Type 1 Diabetes Mellitus
Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus
In this prospective, dual-center, open trial, patients with recent onset type 1 diabetes will receive one dose of allogenic Adipose tissue-derived stromal/stem cells (1x106 cells/kg) and oral cholecalciferol 2000UI/day for 24…
- Trial name
- NCT03920397
- Testing
- Infusion of adipose tissue-derived stem/stromal cells and oral Cholecalciferol supplementation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Rheumatoid Arthritis, Hypovitaminosis D
Treatment of Hypovitaminosis D in Rheumatoid Arthritis
This study recruits individuals with rheumatoid arthritis (RA) and low vitamin D concentrations. Subjects are dosed with vitamin D or placebo for one year.
- Trial name
- NCT00423358
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Wisconsin, Madison
Rheumatoid Arthritis
A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis
This 3 arm study will compare the safety and efficacy, with regard to reduction of signs and symptoms, of tocilizumab versus placebo, both in combination with methotrexate (MTX).
- Trial name
- NCT00106548
- Testing
- tocilizumab [RoActemra/Actemra], Methotrexate
- Where
- 74 sites in Argentina, Australia and 15 more
- Volunteers
- 623 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis, Relapsing-Remitting
Rehabilitation Study in MS Patients
Studying the effectiveness of a functional rehabilitation protocol (FRP) in early Relapsing Remitting Multiple Sclerosis (RRMS) patients treated with Betaferon by comparing the physical ability of patients with and without FRP.
- Trial name
- NCT00780455
- Testing
- Interferon beta-1b, FRP within 15 days after randomization, Interferon beta-1b, FRP about 6 weeks after randomization
- Where
- 10 sites in France
- Volunteers
- 4 people
- Sponsor
- Bayer
Secondary Progressive Multiple Sclerosis
A Study for Patients With Multiple Sclerosis
To obtain additional safety data in subjects who have previously completed the MBP8298-01 study "A Double Blind Placebo Controlled Multi-Centre to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Multiple…
- Trial name
- MAESTRO-02 (NCT00870155)
- Testing
- dirucotide
- Where
- 10 sites in Canada, Denmark and 8 more
- Volunteers
- 546 people
- Sponsor
- Eli Lilly and Company
Multiple Sclerosis, Chronic Pain
MS Symptom Management Study
People with Multiple Sclerosis (MS) often have pain and/or fatigue. Unfortunately, available treatments provide inadequate relief for the majority of these individuals.
- Conditions
- Multiple Sclerosis, Chronic Pain, Fatigue
- Trial name
- ENHANCE (NCT02474940)
- Testing
- Intervention #1, Intervention #2, Intervention #3
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Washington
Type 1 Diabetes
Impact of Introducing Basaglar Insulin to the Treatment Regimen of Youth With Diabetes in Pakistan
This study aimed to determine the effect of introducing Basaglar and insulin pen injection devices on clinical and quality of life (QOL) parameters in children and young adults with type 1 diabetes in Pakistan
- Trial name
- NCT06717191
- Testing
- biosimilar insulin glargine
- Where
- Pakistan
- Volunteers
- 296 people
- Sponsor
- Life for a Child Program, Diabetes Australia
Multiple Sclerosis
Validation of the French Adaptation of the MSWDQ-23 Questionnaire
MS is an autoimmune disease of the central nervous system that affects more than 120,000 people in France. The average age of onset of the disease is between 25 and 35 years.
- Trial name
- WORKSEP (NCT04860791)
- Testing
- questionnaires
- Where
- 16 sites in France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis
MEsenchymal StEm Cells for Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which ultimately leads to myelin damage and axonal loss.
- Trial name
- MESEMS (NCT02403947)
- Testing
- Mesenchymal stem cells, Suspension media
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Toulouse
Osteoarthritis, Rheumatoid Arthritis
Ankle Joint Replacement Outcomes Study
This post market outcome study will look at the therapeutic results of the Salto Talaris Anatomic ankle prosthesis. The study population will consist of patients who will undergo an ankle arthroplasty procedure with a Salto…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis
- Trial name
- NCT00503438
- Testing
- Salto Talaris Ankle
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Smith & Nephew, Inc.
Generalized Myasthenia Gravis, gMG
A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab
This is a prospective, multicenter single arm study designed to evaluate the effectiveness and safety of a predefined oral corticosteroids (OCS) tapering schedule to reduce OCS use in adult participants with acetylcholine…
- Trial name
- OCTAGON (NCT07221838)
- Testing
- Oral Corticosteroid Tapering Schedule, Ravulizumab, Prednisone/Prednisolone
- Where
- 12 sites in United States, Germany and 2 more
- Volunteers
- 75 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Arthritis, Rheumatoid
A Study To Evaluate The Safety And Pharmacokinetic Profile Of A P38 Inhibitor (PH-797804) In Subjects With Rheumatoid Arthritis Who Are Also Taking Methotrexate
The hypothesis of this study is that the p38 inhibitor (PH-797804) will be safe and well tolerated in subjects with rheumatoid arthritis who are taking methotrexate and will not effect the blood levels of methotrexate.
- Trial name
- NCT00620685
- Testing
- PH-797804
- Where
- 7 sites in United States
- Volunteers
- 27 people
- Sponsor
- Pfizer
Hypoglycemia Unawareness
Carvedilol in Treating Hypoglycemia Unawareness
Type 1 diabetes mellitus (T1DM) can lead to cardiovascular, renal and neurological complications if left poorly-controlled over prolonged periods of time.
- Trial name
- NCT03538015
- Testing
- Carvedilol 3.125 mg, Carvedilol 2.5 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Owen Chan, PhD
Rheumatoid Arthritis(RA)
A Study Assessing the Efficacy and Safety of SM03 in Patients With Active Rheumatoid Arthritis Receiving MTX
To demonstrate that SM03 added to methotrexate (MTX) reduce signs and symptoms of rheumatoid arthritis (RA) in Chinese RA participants with an inadequate response to MTX.
- Trial name
- NCT04312815
- Testing
- SM03, MTX
- Where
- China
- Volunteers
- 510 people
- Sponsor
- SinoMab BioScience Ltd
Multiple Sclerosis, Relapsing-Remitting
Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) affecting roughly 900,000 people in the United States that frequently results in impaired mobility.
- Trial name
- NCT04073940
- Testing
- Targeted Ballet Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois at Urbana-Champaign
Rheumatoid Arthritis
A Study of Iguratimod in Patients With Active Rheumatoid Arthritis
This study is intended to evaluate the safety and efficacy of Iguratimod in patients with active Rheumatoid Arthritis.
- Trial name
- NCT01554917
- Testing
- Iguratimod
- Where
- China
- Volunteers
- 1,759 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Type 1 Diabetes Mellitus
The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children
To determine whether insulin glulisine decreases the breakfast post prandial glycemic excursion in comparison to insulin aspart.
- Trial name
- NCT00913497
- Testing
- insulin glulisine, insulin aspart
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Corewell Health West
Type 1 Diabetes Mellitus
Continuous Glucose Monitoring to Measure Effect of Glycemic Index
Background: Post-prandial hyperglycemia is common in people with type 1 diabetes. Objective: The aim was to determine the impact of low vs high glycemic index (GI) on post-prandial glycemia for breakfast vs lunch and to quantify…
- Trial name
- NCT01145547
- Testing
- Dexcom Seven® Plus Continuous Glucose Monitoring sensor
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Arthritis, Arthritis, Rheumatoid
An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis
The purpose of this study is to examine whether an magnetic resonance imaging (MRI) -guided treatment strategy based on a predefined treatment algorithm can prevent progression of erosive joint damage, increase remission rate and…
- Conditions
- Arthritis, Arthritis, Rheumatoid, Joint Diseases, Musculoskeletal Diseases
- Trial name
- IMAGINE-RA (NCT01656278)
- Testing
- Magnetic resonance imaging (MRI), Conventional biochemical and clinical examinations
- Where
- 9 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen
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