Clinical trials: Autoimmune State
Type2 Diabetes, Gestational Diabetes
Metabolic Risk and Life Style Factors in Women With Previous Gestational Diabetes Mellitus (GDM)
Women with previous Gestational Diabetes Mellitus (GDM) are characterized by several metabolic abnormalities i.e. insulin resistance, beta-cell dysfunction and increased risk of later Diabetes Mellitus (DM).
- Conditions
- Type2 Diabetes, Gestational Diabetes, Life Style
- Trial name
- NCT03050645
- Where
- Denmark
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Diabetes Mellitus, Type 1
Anti-viral Action Against Type 1 Diabetes Autoimmunity
The study GPPAD-05 AVAnT1A is a phase 4 clinical trial intending to enroll 2252 children, who will be randomly assigned to receive COVID-19 vaccination (Comirnaty® 3 μg Omicron XBB.1.5 or new variant Comirnaty vaccines ) or…
- Trial name
- NCT06452654
- Testing
- Comirnaty Injectable Product, Sodium Chloride 0.9% Inj
- Where
- 9 sites in Austria, Belgium and 3 more
- Volunteers
- 2,252 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Type 1 Diabetes
Stem Cell Educator Therapy in Type 1 Diabetes
The translational potential to the clinical applications of cord blood stem cells has increased enormously in recent years, mainly because of its unique advantages including no risk to the donor, no ethical issues, low risk of…
- Trial name
- NCT01350219
- Testing
- Stem Cell Educator
- Where
- 4 sites in China, Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Throne Biotechnologies Inc.
Pregnancy, Thyroid Autoimmune Disease
Potential Preventive Effect of Selenium on Iodine-induced Thyroid Autoimmunity During Pregnancy
In 1994, the WHO and UNICEF Joint Committee on Health Policy recommended Universal Salt Iodization as a safe, cost-effective and sustainable strategy to ensure sufficient intake of iodine by all individuals.
- Conditions
- Pregnancy, Thyroid Autoimmune Disease, Iodine Deficiency, Selenium Deficiency
- Trial name
- NCT03377218
- Testing
- Iodine, Iodine + Selenium
- Where
- Latvia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Riga Stradins University
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Myocarditis, Ventricular Arrhythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOPED (NCT06591260)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Prevention of COVID19
Immunogenecity and Safety of VaccinemRNA-1273 in Elderly Volunteers (Over 65 y) Compared to Younger Ones (18-45y)
This study aims to evaluate the immunogenicity of Moderna mRNA-1273 vaccine in volunteers aged 65 years or more compared to volunteers aged 18-45 years, over 24 months duration.
- Trial name
- CoviCompareM (NCT04748471)
- Testing
- mRNA-1273
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lymphoproliferative Disorders, Autoimmune Lymphoproliferative
Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
Background: Blood stem cells in the bone marrow make all the cells to normally defend a body against disease. Allogeneic blood or marrow transplant is when these stem cells are transferred from one person to another.
- Conditions
- Lymphoproliferative Disorders, Autoimmune Lymphoproliferative, Primary T-cell Immunodeficiency Disorders, Immune System Diseases
- Trial name
- NCT03663933
- Testing
- e-ATG, Immunosuppression Only Conditioning, Reduced Intensity Conditioning
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Autoimmune Encephalitis
Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis
Autoimmune encephalitis is brain inflammation caused by the immune system mistakenly reacting against proteins in the brain. The commonest form is called NMDAR-antibody encephalitis (N-methyl-D-aspartate receptor antibody…
- Trial name
- DANCE-AE (NCT05280600)
- Testing
- Not applicable - non-interventional study
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King's College London
Vitamin D, Thyroid Autoimmune Disease
Vitamin D, Hashimato's Thyroiditis and Thyroid Functions
The goal of this retrospective observational study is to determine whether vitamin D levels differ in patients with Hashimoto's thyroiditis (HT) compared to those without Hashimoto's thyroiditis.
- Trial name
- NCT06726967
- Testing
- vitamin D 25(OH)D
- Where
- Turkey (Türkiye)
- Volunteers
- 81,180 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Type 1 Diabetes Mellitus
Biomarkers of Type 1 Diabetes in Children and Their Healthy Siblings
This prospective observational cohort study evaluated genetic, immunologic, and environmental factors associated with type 1 diabetes in children.
- Trial name
- NCT07627230
- Where
- Russia
- Volunteers
- 1,034 people, healthy volunteers welcome
- Sponsor
- Privolzhsky Research Medical University
Arthritis, Rheumatoid
Phase 1 Dose Escalating Study to Assess Safety, Tolerability, Food Effect and PK of CHR-5154 in Healthy Male Volunteers
Primary Objective: To determine the safety and tolerability of single and multiple ascending oral doses of CHR-5154 in healthy volunteers.
- Trial name
- NCT01934101
- Testing
- CHR-5154
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pemphigus
Coagulation Activation in Patients With Pemphigus
Aim of work: 1. To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls. 2.
- Trial name
- NCT06285435
- Testing
- prothrombin fragment 1+2
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Beta-cell Autoimmunity
Insulin-free Cow Milk Formula in Prevention of Type 1 Diabetes Associated Autoimmunity - FINDIA Pilot Study
The purpose of this study is to determine whether weaning to whey-based hydrolysed formula or essentially bovine insulin free whey-based FINDIA formula instead of standard cow's milk based formula is effective in the prevention…
- Trial name
- FINDIA (NCT01055080)
- Testing
- Cow's milk formula
- Volunteers
- 987 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Type 1 Diabetes, Prediabetic State
Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D
This protocol is an intervention study to determine the best education and monitoring strategy for children ages 2-20 years with pre-symptomatic type 1 diabetes (T1D) because there currently exists no clinical guidelines for…
- Conditions
- Type 1 Diabetes, Prediabetic State, Dysglycemia, Autoimmune Diabetes
- Trial name
- TESS (NCT04335513)
- Testing
- Early CGM-guided education and initiation of insulin therapy., Usual care: glucometer surveillance and basic education.
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Systemic Lupus Erythematosus
Autoimmunity in Sisters of Lupus Patients
This study enrolled over 400 unaffected sisters of young women diagnosed with SLE. These unaffected sisters are being followed with an annual health questionnaire (CSQ) and blood sample.
- Trial name
- SisSLE (NCT01076101)
- Where
- United States
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Diabetes, Celiac Disease
Gfree - For Improved Blood Sugar and Reduced Inflammation.
The goal of this clinical trial is to reduce inflammation and improve glycemic control in healthy volunteers, parents, as well as children, adolescents and adults with or without diabetes.
- Conditions
- Diabetes, Celiac Disease, Autoimmunity, Metabolic Disease
- Trial name
- NCT05894746
- Testing
- gluten-free, probiotic, gluten
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Periodontitis, Rheumatoid Arthritis, Autoimmunity,
Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease
The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.
- Trial name
- NCT02577679
- Where
- Taiwan
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease
Antigen Presentation and Lymphocyte Response in Parkinson's Disease
The way the immune system responds to certain PD-related proteins in PD donors compared to the way it responds in persons without or fewer PD related proteins is not well studied and this study aims to analyze the autoimmune…
- Trial name
- NCT02939534
- Where
- 3 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Columbia University
Multiple Sclerosis
Allocentric Memory in MS and Resting State Functional MRI
The goals of this study are to 1. Investigate the sensitivity of allocentric visual memory when compared to more established measures of cognition in identifying cognitive difficulties among MS subjects when compared to controls.
- Trial name
- NCT02118298
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University