Clinical trials: Autonomic Nervous System Disorders
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy Volunteers
A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)
The purpose of this healthy volunteers drug-drug interaction study is to assess the CYP1A2 and CYP3A4 perpetrator interaction potential and CYP1A2 victim potential of TEV-56286 (anle138b).
- Trial name
- NCT05532358
- Testing
- anle138b (TEV-56286), Fluvoxamine 100 mg QD for 5 days
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Postural Orthostatic Tachycardia Syndrome (POTS)
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.
- Trial name
- NCT00962949
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Autonomic Dysfunction, Autonomic Imbalance
Non-Invasive Bioelectronic Analytics
Biomarkers can be evaluated to provide information about disease presence or intensity and treatment efficacy. By recording these biomarkers through noninvasive clinical techniques, it is possible to gain information about the…
- Conditions
- Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
- Trial name
- NIBA (NCT04100486)
- Testing
- Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Postexercise Hypotension
Continuous vs Aerobic Postexercise Hypotension
This study examines the effect of obesity and gender on postexercise hypotension with three different randomized exercise protocols or varying intensity.
- Trial name
- CAPER (NCT03313375)
- Testing
- Continuous Exercise, Aerobic Interval Exercise
- Where
- 2 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Complex Regional Pain Syndrome Type I
Longitudinal Follow-up Study About Complex Regional Pain Syndrome (CRPS) Patients
Complex regional pain syndrome (CRPS) is a post-traumatic chronic pain condition characterized by pain and other symptoms typically affecting a distal limb.
- Trial name
- NCT04703647
- Testing
- Administration of questionnaires for prospective group, Blood samples for prospective group, Blood samples for control group
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Asthma
A Study to Evaluate the Safety, Tolerability and Absorption to the Blood After Administration of Single and Multiple Doses of AZD8154 in Healthy Participants.
This study is a Phase 1, first in human (FiH) study, consisting of 3 parts (Part 1, Part 2, and Part 3) in healthy male and female participants of non-childbearing potential, performed at a single study center.
- Trial name
- NCT03436316
- Testing
- AZD8154
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COPD, Sympathetic Nervous System Diseases
Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Conditions
- COPD, Sympathetic Nervous System Diseases, Catecholamine; Overproduction
- Trial name
- SNAP-COPD (NCT04849806)
- Testing
- Assessments of the sympathetic nerve activity axis, OSA severity, Determination of PH and right HF severity
- Where
- Germany
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Arthroscopic Knee Surgery, Lower Limb Fractures
Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes
This study compares the gait pattern of individuals with weight bearing difficulties walking on the floor, a soft surface, or with special shoes (Kyboot).
- Conditions
- Arthroscopic Knee Surgery, Lower Limb Fractures, Back Pain and Asymmetric Gait, Complex Regional Pain Syndrome
- Trial name
- NCT02742376
- Testing
- Soft surface, Floor, Kyboot shoes
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Restless Legs Syndrome, Multiple Sclerosis
Hypnosis and Direct Autonomic Experience Influence on Chronic Symptoms
Study will look at a limited number of participants with various chronic symptoms. Investigating a new and novel form of hypnosis application called "Direct Autonomic Experience (DAX)" which is using combination of visualization…
- Conditions
- Restless Legs Syndrome, Multiple Sclerosis, Trauma, Psychological, Chronic Disease
- Trial name
- HDAX1 (NCT04303143)
- Testing
- Self-Hypnosis, Direct Autonomic Experience Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inner Group Inc.
Vasovagal Syncope, Smoke Inhalation
Relation Between Vasovagal Tendency and Smoking Among University Students
Almost everyone is aware these days is aware about the risk of smoking. Still many people start this habit specially in early life and during college year.
- Trial name
- NCT02949804
- Testing
- Comparison between two groups
- Where
- Jordan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jordan Collaborating Cardiology Group
Fibromyalgia Syndrome
Palpitations and Tachycardia in Fibromyalgia Syndrome
Clinically Characterized by the presence of chronic widespread pan and tenderness, Fibromyalgia (FM) is one of the most common "functional" syndromes. FM is currently conceived of as representing a prototype of central pain, i.e.
- Trial name
- NCT01147263
- Testing
- Evaluation of autonomic parameters
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Orthostatic Hypotension, Nondipping Hypertension
Is Orthostatic Hypotension Associated With Nondipping Hypertension
The aim of the study is to evaluate whether orthostatic hypotension is associated with nondipping hypertension. Methods and patients: 400 subjects who are referred for 24hABPM will be filled questioner regarding their medical…
- Trial name
- NCT00491231
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Spinal Cord Injury
Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury
This clinical study is designed to investigate the mechanisms of blood pressure regulation and respiratory motor function affected by spinal cord injury (SCI).
- Trial name
- NCT02154412
- Testing
- Respiratory Training
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Insulin Sensitivity
The Importance of Insulin Action in the Brain for the Immune System During Physical Activity
The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests.
- Trial name
- NCT06552130
- Testing
- Spiroergometer test with intranasal insulin spray
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulm
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium Stage 2
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies
- Trial name
- NAPS2 (NCT05826457)
- Where
- 9 sites in United States, Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease, Autonomic Dysfunction
Parkinson's Autonomic Responses to Treadmill Walking
This study will compare examine autonomic and cardiovascular responses to peak exercise testing in Parkinson's disease patients in varying stages of the disease, and healthy, age-matched participants.
- Trial name
- NCT03156400
- Testing
- Exercise Stress Test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial
The purpose of this study IS to explore the underlying pathophysiology of chronic fatigue syndrome (CFS) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions to…
- Trial name
- NorCAPITAL (NCT01040429)
- Testing
- Clonidine, Lactose capsula
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Blood Pressure, Post-Exercise Hypotension
The Effects of Dietary Salt on Post-exercise Hypotension
The new American Heart Association (AHA) blood pressure guidelines are expected to raise the prevalence of high blood pressure to ~46% in the United States.
- Trial name
- NCT03565653
- Testing
- High dietary salt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware