Clinical trials: Autonomic Nervous System Dysfunction
ROHHAD Syndrome
Treatment of Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation (ROHHAD )
ROHHAD (rapid onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation) syndrome is a rare pediatric disorder associated with a cancer called neuroblastoma and presumed to be driven by an attack of…
- Trial name
- NCT02441491
- Testing
- Cyclophosphamide
- Where
- United States
- Sponsor
- Johns Hopkins University
Heart Failure
Nutritional Therapy for Autonomic Dysfunction in Elderly Heart Failure Patients
Recent studies suggest that patients with heart failure (HF) may have a reduced ability to control the tone of their blood vessels, heart rate or blood pressure in response to stress.
- Trial name
- NCT06256276
- Testing
- Whey protein powder and L-carnitine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Arkansas
Heart Failure, Systolic Dysfunction
A Pilot Study of Spinal Cord Stimulation in Heart Failure Patients With Depressed Left Ventricular Function
A randomized pilot study of spinal cord stimulation in patients with chronic heart failure aiming to show whether this therapy impacts central haemodynamic and autonomic regulations.
- Trial name
- RAPID-HELP (NCT02450110)
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q.3
It has been found that in some cases, when a person with Diabetes Mellitus has an episode of low blood sugar,or hypoglycemia, and then later exercises, he or she is vulnerable to another bout of hypoglycemia during that exercise.
- Trial name
- NCT00742521
- Testing
- glucose clamp
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University
Fibromyalgia
Peripheral Arterial Tonometry (PAT) Evaluation of Sleep in Fibromyalgia
Fibromyalgia syndrome (FMS) is characterized by the presence of widespread pain, chronic fatigue and typical sleep disturbances.
- Trial name
- NCT01151163
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Stroke, Autonomic Dysfunction
Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction
The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle…
- Conditions
- Stroke, Autonomic Dysfunction, Hemiparesis
- Trial name
- NCT07482501
- Testing
- rTMS M1 Motor Cortex Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Afyonkarahisar Health Sciences University
Takotsubo Cardiomyopathy
The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome
TakoTsubo Syndrome (TTS) constitutes an increasingly recognised, heterogenous clinical entity which is associated with considerable short-term mortality.
- Trial name
- SYMPATAK (NCT04695587)
- Testing
- 123 MIBG scintigraphy testing, MSNA, ABPM
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hippocration General Hospital
Chronic Kidney Diseases
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD)
30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in…
- Trial name
- NCT06927024
- Testing
- Active taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Non-alcoholic Fatty Liver Disease, NAFLD
Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease
There is a significant association between autonomic dysfunction and symptoms experienced by NAFLD patients mediated by increased systemic inflammation and insulin resistance, resulting in deteriorating quality of life of…
- Conditions
- Non-alcoholic Fatty Liver Disease, NAFLD, Fatty Liver, Nonalcoholic, Nonalcoholic Fatty Liver Disease
- Trial name
- AD-NAFLD (NCT02132780)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Commonwealth University
Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia
Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial
The goal of this clinical trial is to learn whether guanfacine or cromolyn sodium can improve symptoms and physical functioning in adults with Postural Orthostatic Tachycardia Syndrome (POTS).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia, Orthostatic Intolerance, Autonomic Nervous System Diseases
- Trial name
- DBPOTS (NCT07757555)
- Testing
- Guanfacine (GFC), Cromolyn Sodium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Autonomic Disturbances in Parkinson's Disease
Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment
Disabling symptoms of blood pressure dysregulation, impaired swallowing and digestion are common amongst Parkinson's patients. So far the exact pathophysiology for this is not fully understood.
- Trial name
- NCT01993680
- Testing
- Pyridostigmine bromide, fludrocortisone
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Christian Baumann
Syncope, Blood Injury Phobia
fMRI in Blood Phobia Syncope
We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain…
- Conditions
- Syncope, Blood Injury Phobia, Autonomic Dysfunction
- Trial name
- NCT00715065
- Testing
- fMRI Scan
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postural Tachycardia Syndrome
fMRI in Postural Tachycardia Syndrome
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is…
- Trial name
- POTS (NCT04137757)
- Testing
- Lower Body Negative Pressure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Chronic Low Back Pain (CLBP), Chronic Neck Pain
Comparative Analysis of Heart Rate Variability in Patients with Cervical Pain, Lumbar Pain, and Healthy Controls
This is a cross-sectional study designed to evaluate potential differences in heart rate variability (HRV) indices based on the affected body region (cervical vs lumbar) in individuals with chronic pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Neck Pain, Heart Rate Variability, Autonomic Nervous System Dysfunction
- Trial name
- NCT06890793
- Where
- Spain
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura
Endothelial Dysfunction, Autonomic Dysfunction
Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function
The American College of Sports Medicine (ACSM) recommends that resistance exercise performed at greater than 70% one repetition maximum (1 RM) is necessary to induce strength gains and muscular hypertrophy (ACSM, 2009).
- Trial name
- NCT03225898
- Testing
- Resistance Exercise with Blood Flow Restriction, High-intensity Resistance Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kent State University
Chronic Nausea, Anxiety
AROMA-NT: Essential Oils and Wearable TENS Device for Chronic Nausea
This study will investigate how two inhaled essential oil products (QueaseEASE and STILL) and a wearable transcutaneous electrical nerve stimulation (TENS) device (ReliefBand) affect chronic nausea and anxiety in adults with…
- Trial name
- AROMA-NT (NCT07720336)
- Testing
- Inhaled Essential Oils, Wearable TENS Device
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Ohio State University
Androgen Deprivation Therapy, Prostate Cancer
Autonomic and Renal Contributions to Hypertension With ADT
This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer.
- Conditions
- Androgen Deprivation Therapy, Prostate Cancer, Hypertension, Autonomic Dysfunction
- Trial name
- ARCH (NCT07848828)
- Testing
- Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Fibromyalgia, Autonomic Dysfunction
The Effects of Inspiratory Muscle Training Female Patients With Fibromyalgia
Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and psychological symptoms.
- Trial name
- NCT07261696
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Nigde Omer Halisdemir University
Neuropathic Pain, Depression
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
Spinal cord Injury (SCI) is a condition commonly associated with a state of chronic low-grade inflammation due to a variety of factors such heightened risk for infection and development of metabolic disorders.
- Conditions
- Neuropathic Pain, Depression, Cognitive Impairment, Somatic Neuropathy
- Trial name
- NCT02099890
- Testing
- Omega-3, Vegetation Protein Powder, InflanNox
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brock University
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic