Clinical trials: Autophagy
Dietary Protein
Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling
High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease.
- Trial name
- mTOR (NCT03946774)
- Testing
- Dietary protein shake
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Depression, Healthy
An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation
Recently, the autophagy inducing caloric restriction mimic spermidine became available. Autophagy is essential for energy and cellular homeostasis through protein catabolism and dysregulation results in compromised proteostasis…
- Trial name
- NCT04823806
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Mild Cognitive Impairment Due to Alzheimer's Disease, Subjective Cognitive Decline (SCD)
Autophagy-Enhancers to Reduce Sleep Disturbances
This clinical trial investigates the effects of spermidine supplementation on sleep quality and sleep-dependent memory consolidation in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI), two…
- Trial name
- SpSleep (NCT07383311)
- Testing
- Spermidine Supplementation
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Uterine Fibroid
The Role of Fibroblast Activation in Uterine Fibroid
Uterine fibroids (UFs), also called uterine leiomyomas or myomas, are steroid hormone-responsive, benign tumors of the smooth muscle compartment (myometrium) of the uterus.
- Trial name
- NCT03444987
- Testing
- Measurement of protein expression in tissues.
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Assiut University
COVID-19, Vaccine Reaction
Improving Vaccination in Older Adults by Inducing Autophagy With Spermidine
Easing the morbidity and economic burden of age-related diseases is one of the major medical challenges. One of the key obstacles to healthy ageing is immune senescence, including the failure of lymphocytes to respond adequately…
- Trial name
- NCT05421546
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Exercise, Exercise Test
Multi-level Molecular Profiling of Peak Performance in Endurance Sports
Physical activity triggers complex molecular responses, including changes in immune-, stress-, and metabolic pathways. For example, autophagy is essential for energy and cellular homeostasis through protein catabolism, and…
- Conditions
- Exercise, Exercise Test, Physical Fitness, Healthy
- Trial name
- MSSA (NCT05359744)
- Testing
- Performance testing
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Supplement, Resistance Training Adaptation
Skeletal Muscle Adaptations to Peptide-Supplemented Resistance Exercise Training
Skeletal muscle size, an important metabolic tissue, is governed by the balance between two opposing processes, muscle protein synthesis and muscle protein breakdown.
- Trial name
- NCT07773142
- Testing
- Resistance Exercise Training with or without daily supplementation, Dual Energy X-Ray Absorptiometry (DEXA) Scan, Muscle Sampling
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Mitochondrial Degradation, Autophagy
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
- Conditions
- Mitochondrial Degradation, Autophagy, Fasting, Healthy Volunteers
- Trial name
- MITO FAST (NCT07638696)
- Testing
- Ramadan Intermittent Dry Fasting (Sawm), 16:8 Time-Restricted Feeding (TRF)
- Where
- Cyprus
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bahcesehir Cyprus University
Aging, Frailty
Mitophagy and Autophagy in Elderly Subjects
In recent years, evidence has shown that mitochondrial dysfunction plays an important role in the development of age-related muscle decline that may lead to frailty.
- Conditions
- Aging, Frailty, Mitophagy
- Trial name
- NCT02472340
- Testing
- Muscle Biopsy
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Vascular Diseases
Autophagy Maintains Vascular Function Through a Novel Glycolysis-linked Pathway Regulating eNOS
Aging is inevitable and is the primary risk factor for developing cardiovascular disease. The molecular mechanisms that drive vascular dysfunction in the context of aging are incompletely understood.
- Trial name
- NCT04200560
- Testing
- Rhythmic Handgrip Exercise, Chronic Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Utah
Intermittent Fasting, Metabolic Dysfunction-Associated Fatty Liver Disease
Intermittent Fasting and Metabolic Dysfunction Associated Fatty Liver Disease
Previous studies have investigated the effect of different dietary patterns on metabolic dysfunction-associated fatty liver disease (MAFLD), for which lifestyle modification remains the primary treatment.
- Trial name
- NCT06664684
- Testing
- Energy-restricted dietary intervention, Energy + time-restricted dietary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Vitiligo
Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo
The present study will aim to evaluate: 1. The presence of Hypoxia Inducible Factor in vitiligo patient 2. Defect of Autophagy Related Genes in vitiligo patient 3.
- Trial name
- NCT06410898
- Testing
- Punch Biopsy 5mm
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Healthy
Very Low-calorie Diet & Cardiometabolic Health
To investigate the effects of a short-term (1-week) nutritional intervention in healthy individuals using very low-calorie (fasting-mimicking) diets with different protein content on markers of cardiometabolic health and…
- Trial name
- NCT06560996
- Testing
- Very low calorie diet with low protein content (VLCD-LP group), Very low calorie diet with high protein content (VLCD-HP group)
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Diet, Autophagy
Fasting Mimicking Diet and Autophagy
This study aims to evaluates autophagy in circulating white blood cells from generally healthy human volunteers exposed to fasting mimicking diet (FMD), a 5-day dietary regimen.
- Trial name
- NCT06115551
- Testing
- Fasting Mimicking Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- L-Nutra Inc
Psoriasis Vulgaris, Autophagy
ATG5 as a Serum Marker of Autophagy in Psoriatic Patient
it will be of interest to know the ATG 5 as a serum marker of autophagy in serum of psoriasis vulgairs patients and explore its relationship with psoriasis severity.
- Trial name
- NCT05279638
- Testing
- serum ATG5
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Neonatal Encephalopathy, Cell Damage
Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)
Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Neonatal encephalopathy (NE) occurs in 1.8 to 7.7 infants per 1000 births.
- Conditions
- Neonatal Encephalopathy, Cell Damage, Metabolic Acidosis, Inflammation
- Trial name
- AGAIN (NCT03897101)
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Endometrial Polyp, Autophagy
Autophagy Markers in Endometrial Polyps
The aim of this research is to evaluate autophagy markers in patients with endometrial polyps
- Trial name
- NCT04706000
- Testing
- Beclin 1 gene
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Uterine Cervical Neoplasms
MR Metabolic Biomarkers for Cervical Cancer
The purposes of this study are: (1) to develop magnetic resonance (MR) imaging and spectroscopy as surrogate biomarkers for altered cancer metabolism in cervical cancer; (2) to understand the function of human papillomavirus…
- Trial name
- NCT01874548
- Where
- Taiwan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Depression - Major Depressive Disorder, Overweight (BMI > 25)
Fasting, Exercise, and Diet to Activate Autophagy in Depression
Depression is a common mental health condition that affects millions of people worldwide and is a leading cause of disability. Although current treatments can be effective, many patients do not fully recover or experience…
- Trial name
- AutoFast (NCT07664540)
- Testing
- Performance test
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich