Clinical trials: Axillary Lymph Nodes
Lymphedema, Breast Cancer
Preventing Lymphedema in Axillary Lymph Node Dissection
The researchers are trying to answer if axillary reverse mapping (ARM) with lympho-venous bypass (LVB) in patients undergoing an axillary lymph node dissection reduces the rate and severity of post-operative lymphedema of the arm.
- Conditions
- Lymphedema, Breast Cancer, Melanoma
- Trial name
- NCT03428581
- Testing
- ALND with ARM +/- LVB, ALND
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- Mayo Clinic
Breast Cancer, Sentinel Lymph Node
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
- Trial name
- ATNEC (NCT04109079)
- Testing
- Axillary lymph node dissection, Axillary radiotherapy, Breast or chest wall radiotherapy
- Where
- 98 sites in Ireland, United Kingdom
- Volunteers
- 1,900 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer
Axillary Sentinel Lymph Node Detection in Breast Cancers > 2 cm
The purpose of this study is to evaluate the quality criteria of the SLN detection technique in breast cancer patients with a tumor size (clinical measurement) greater than 2 centimeters (rate of false negatives, rate of…
- Trial name
- GAS2PLUS (NCT00636467)
- Testing
- No name
- Where
- 22 sites in France
- Volunteers
- 249 people
- Sponsor
- Centre Leon Berard
Breast Cancer
Breast Lymph Node Mapping
The purpose of this study is to map the arm lymphatic drainage system in the axilla with blue dye and the breast drainage system with a radioactive material.
- Trial name
- NCT01038908
- Testing
- Isosulfan Blue (Patent Blue Dye V)
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Recurrent Breast Cancer
Reoperative Sentinel Lymph Node Biopsy in Patients With Recurrent Ipsilateral Breast Cancer
The goal of this observational study is to assess the effectiveness of sentinel lymph node biopsy as a treatment approach for patients with recurrent breast cancer on the same side as previous surgeries.
- Trial name
- RENATA (NCT06329089)
- Testing
- Reoperative Sentinel Lymph Node Biopsy
- Where
- Spain
- Volunteers
- 97 people
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer
Current Value of Axillary Ultrasound in the Staging of Breast Cancer. Is BSGC Still Necessary?
AUS/FNAC allows the identification of tumors without axillary tumor involvement, or with low axillary tumor burden, many of which do not benefit from SLNB, in the staging of early breast cancer.
- Trial name
- NCT03193008
- Where
- Spain
- Volunteers
- 1,400 people
- Sponsor
- Corporacion Parc Tauli
Stage I Breast Cancer, Stage II Breast Cancer
Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer
This clinical trial will enroll up to 130 adult women with a confirmed diagnosis of clinical stage 1 or 2 breast cancer who are undergoing breast cancer surgery with lumpectomy or mastectomy and planned axillary sentinel node…
- Trial name
- NCT02419807
- Testing
- Indocyanine Green Solution, Technetium Tc-99m Sulfur Colloid, Lymphoscintigraphy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Case Comprehensive Cancer Center
Malignant Neoplasm of Breast.
Discordant Hormonal Status of Breast Cancer.
The purpose of this study is to determine discordant hormonal status of primary breast tumor and metastatic breast cancer cells at regional lymph nodes in node positive breast cancer patients.
- Trial name
- NCT01943032
- Where
- Thailand
- Volunteers
- 105 people
- Sponsor
- National Cancer Institute, Thailand
Breast Cancer
POSNOC - A Trial Looking at Axillary Treatment in Early Breast Cancer
POSNOC is a pragmatic, randomised, multicentre, non-inferiority trial. Aim For women with early stage breast cancer and one or two sentinel node macrometastases, to assess whether adjuvant therapy alone is no worse than adjuvant…
- Trial name
- POSNOC (NCT02401685)
- Testing
- Adjuvant therapy, Axillary treatment
- Where
- 50 sites in Australia, New Zealand and 1 more
- Volunteers
- 1,900 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer
Accuracy of FNA Versus CNB of Abnormal Axillary Lymph Nodes in Setting of Invasive Breast Cancer
To compare accuracy of ultrasound guided fine needle aspiration (FNA) to core needle biopsy (CNB) of ultrasound detected abnormal axillary lymph nodes in patients with newly diagnosed invasive breast cancer or suspected invasive…
- Trial name
- NCT02019303
- Testing
- FNA and Core biopsy
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Utah
Breast Cancer
T1-T2 Breast Cancer: Comparison Between Removal and Preservation of Axillary Lymph Nodes (SINODAR ONE)
Italian Multicentric non inferiority two-arm randomized clinical trial to verify that the experimental treatment (omission of axillary lymph node intervention) in the presence of sentinel lymph node metastases does not lead to a…
- Trial name
- SINODAR ONE (NCT05160324)
- Testing
- Removal of axillary lymph nodes., Preservation of axillary lymph nodes
- Volunteers
- 889 people
- Sponsor
- Fondazione Humanitas per la Ricerca
Breast Cancer
The Accuracy of Sentinel Node Biopsy of Breast Cancer With Sonographic Abnormal Axillary Lymph Nodes
This is a phase II, prospective, single-center, non-randomized, non-controlled study. Sentinel lymph node biopsy (SNB) is a standard staging procedure in early breast cancer.
- Trial name
- NCT02005926
- Testing
- Wire-localized abnormal node
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tao OUYANG
Breast Cancer
Sentinel Lymph Node Biopsy and Primary Tumor Gene Expression Profiling in Finding Axillary Lymph Node Metastases in Women Who Have Received Neoadjuvant Therapy for Stage II, Stage III, or Stage IV Breast Cancer
RATIONALE: Sentinel lymph node biopsy and gene expression profiling of the primary breast tumor may help determine if tumor cells have spread to the axillary lymph nodes and help doctors plan more effective surgery for breast…
- Trial name
- NCT00080860
- Testing
- microarray analysis, immunohistochemistry staining method, conventional surgery
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Breast Cancer
Selective Avoidance of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy In HER-2 Positive/Triple Negative Breast Cancer Patients With Excellent Radiologic Response to the Breast and Axilla, Prospective, Multi-center, Single-arm (ASLAN) Study
The aims of this study is to evaluate 5 year recurrence free survival when omit sentinel lymph node biopsy after neoadjuvant chemotherapy in triple negative or HER-2 positive breast cancer patients when physical examination…
- Trial name
- ASLAN (NCT04993625)
- Testing
- avoid axillary sentinel lymph node biopsy after neoadjuvant chemotherapy
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Jeong Eon Lee
Breast Cancer Female
A Novel Method of Clipped Axillary Lymph Node Localization Post Neoadjuvant Chemotherapy in Breast Cancer Patients .
to determine the feasibility of a novel technique of localization of clipped LN post neoadjuvant chemotherapy
- Trial name
- NCT03878017
- Testing
- skin marking of clip axillary lymph node for localisation
- Where
- Singapore
- Volunteers
- 15 people
- Sponsor
- KK Women's and Children's Hospital
Breast Cancer
Evaluation Of Lymph Nodes After Neoadjuvant Chemotherapy
This research protocol is studying the accuracy of the sentinel lymph node biopsy procedure in breast cancer patients who have cancer cells in the lymph nodes in the armpit (axilla) who have received chemotherapy or endocrine…
- Trial name
- NCT02752009
- Testing
- Axillary Lymph Node Sampling Clip
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Functional Anatomical Examination of Axillary Sentinel Lymph Node Drainage in the Axillary Subregions in Early Breast Cancer
Regional lymph node status is the most important prognostic factor for disease-free and overall survival in breast cancer. Accurate nodal staging can be achieved only by surgery.
- Trial name
- NCT01804309
- Testing
- Sentinel lymph node biopsy (SLNB)
- Where
- Hungary
- Volunteers
- 350 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer, Lymph Node Dissection
Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal Block in Patients Undergoing Breast Cancer Surgery
This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Serratus Posterior Superior Intercostal Plane (SPSIP) and Rhomboid Intercostal Block in patients undergoing Breast Cancer Surgery With…
- Conditions
- Breast Cancer, Lymph Node Dissection, Postoperative Pain, Mastectomy
- Trial name
- SPSIP-RIB (NCT07536867)
- Testing
- Serratus posterior superior intercostal plane block, Rhomboid intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Antalya City Hospital
Virtual Staining, Lymph Node Metastasis
Evaluation of Axillary Lymph Node Metastasis Status of Breast Cancer Based on Pathological Images and Virtual Staining
The goal of this observational study is to develop an artificial intelligence model to transform unstained lymph node tissue slice images directly into stained images.
- Conditions
- Virtual Staining, Lymph Node Metastasis, Breast Cancer, Digital Pathology
- Trial name
- NCT06486155
- Volunteers
- 2,200 people
- Sponsor
- Yunnan Cancer Hospital
Breast Cancer
Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla
The patients undergoing axillary lymph node dissection were randomized into 3 groups: patients undergoing lavages with normal saline (Group 1), patients undergoing lavage gentamicin solution (Group 2) and patients undergoing…
- Trial name
- NCT02314806
- Testing
- Irrigation with gentamicin solution, Irrigation with Clindamycin solution, Irrigation with Normal saline
- Volunteers
- 51 people
- Sponsor
- Hospital General Universitario Elche