Clinical trials: BCAA
Phenylketonuria (PKU)
Brain Aging in Phenylketonuria
Background: Historically, the primary goal in managing phenylketonuria (PKU) has been to prevent severe and irreversible intellectual disability, as well as to address nutritional deficiencies that could lead to growth…
- Trial name
- NCT06969209
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sarcopenia
Technological Processes on Quality of Meat
This project aims to assess the impact of technological processes of meat, as cooking conditions, on amino acid bioavailability and protein metabolism.
- Trial name
- NCT02157805
- Testing
- beef meat
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Pulmonary Disease, Chronic Obstructive
Chronic Obstructive Pulmonary Disorder and Acute Exercise
For this study a resistance bout will be performed in order to promote the robust response of protein synthesis. Type II muscle fibers often exhibit more atrophy than type I fibers in COPD subjects therefore specifically…
- Trial name
- NCT02780219
- Testing
- stable amino acid infusion, acute exercise with amino acid infusion, 24-hour post exercise amino acid infusion
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Polycystic Ovary Syndrome
The Phenotype and Clinical Intervention of High BCAA Type of PCOS
Polycystic ovary syndrome is one of the main diseases leading to infertility in women of childbearing age. In addition to endocrine and reproductive dysfunction, it is often accompanied by significant metabolic abnormalities…
- Trial name
- BCAAPCOS (NCT06192147)
- Testing
- protein restricted diet combined with vitamin D intervention
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Postprandial Plasma Amino Acid Availability
Protein Extrusion and Postprandial Amino Acid Handling
The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders.
- Trial name
- BABE (NCT05584358)
- Testing
- Dry protein blend ingestion, Extruded protein blend ingestion
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Endocrine System Diseases
Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans
With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.
- Trial name
- NCT02563847
- Testing
- 0.52 g L-Tryptophan, 1.56 g L-Tryptophan, 1.56 g L-Leucine
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Liver Steatosis, Insulin Resistance
Effects of Amino Acid Supplementation on Liver Lipid Content and Protein Metabolism in Obese Children
The purpose of this study is to assess the effect of an eight-week dietary supplementation with essential amino acids plus arginine on liver and plasma lipid content, whole-body fat oxidation, whole-body insulin sensitivity…
- Conditions
- Liver Steatosis, Insulin Resistance, Whole Body Protein Metabolism, Body Composition, Beneficial
- Trial name
- NCT02337894
- Testing
- Essential amino acids plus arginine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Safety, Tolerance
Safety and Tolerability of a Novel Amino-acid Based Hydration Drink in Healthy Volunteers
The nutrient composition of this product is similar to the existing Liquid IV "hydration multiplier" product already on the market but with the addition of amino acids.
- Trial name
- NCT05592951
- Testing
- Crystal Light (once serving), Liquid IV with amino acids (one serving), Liquid IV with amino acids (two servings)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Nutritional Stunting, Growth Failure
Nutritional Stimulation of Growth in Children With Short Stature
Short stature is a frequent reason for referral to a pediatric endocrinology clinic. Short stature is especially prevalent among those with failure to thrive (whose weight is significantly below the average weight of his/her…
- Trial name
- NCT04226586
- Testing
- Essential Amino Acid (EAA) group
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Healthy
Sulphur Amino Acid Requirements in Adults >60 Years
This study aims to determine the requirements for the sulphur amino acids in adults over the age of 60 years: 1. the total sulphur amino acid requirement as methionine only. Methionine is an essential amino acid. 2.
- Trial name
- NCT04595188
- Testing
- Sulphur amino acids
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Immune Deficiency, Immune Dysregulation Disorder
Allergy and Immunology Natural History Study
This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation.
- Conditions
- Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation
- Trial name
- NCT05584488
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Metabolic Diseases
Glycemic Response of Co-ingesting Carbohydrate and Amino Acids
The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).
- Trial name
- NCT02455765
- Testing
- Rice and Amino Acid mixtures
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Muscle Protein Synthesis, Protein Metabolism
Time Course of Postprandial Protein Metabolism
The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults.
- Trial name
- NCT04121689
- Testing
- Milk Protein Concentrate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Non-small Cell Lung Cancer
Effects of Essential Amino Acid Intake on Net Protein Synthesis in Weight-losing Non-small Cell Lung Cancer Patients
Weight loss commonly occurs in lung cancer patients, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01172314
- Testing
- EAA+LEU vs total AA, Total AA vs EAA+LEU
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Skeletal Muscle
Leucine or Protein Supplementation and Resistance Training
The purpose of this study was to determine the effects of L-leucine (LEU) or different protein supplements standardized to LEU (~3.0 g/serving) on changes in body composition, strength, and histological attributes in skeletal…
- Trial name
- MPS (NCT03501628)
- Testing
- L-leucine + maltodextrin, Whey protein concentrate, Hydrolyzed whey protein concentrate
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Auburn University
Sarcopenia
Effect of Exercise and Protein Supplementation on Muscle Function in Patients With Hemodialysis
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis.
- Trial name
- NCT04927208
- Testing
- exercise and nutritional support
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Elderly Patients
Citrulline, Exercise Training and Muscle Strength in the Elderly
The aim of this study is to assess the effect of citrulline supplementation on muscle strength in elderly institutionalized subjects undergoing a resistance exercise training program.
- Trial name
- CITREX (NCT01599676)
- Testing
- Citrulline, Non essential amino acid
- Where
- France
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lactation, Breastfeeding, Exclusive
Lysine Requirements During Lactation
The study aims to establish lysine requirements using the indicator amino acid oxidation (IAAO) method in women exclusively breastfeeding a single infant aged 3-4 months, and how maternal lysine needs change once infant…
- Conditions
- Lactation, Breastfeeding, Exclusive, Breastfeeding
- Trial name
- NCT06366204
- Testing
- Dietary Lysine Intakes
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Malnutrition; Protein
True Ileal Amino Acid Digestibility of Tenebrio Molitor Larvae in Women
Dietary protein intake of adequate quality is essential for human health. Traditional animal source foods play a key role in providing high quality protein but are associated with a high burden on the environment.
- Trial name
- NCT05885191
- Testing
- 2H intrinsically-labeled T.molitor with 13-C labeled amino acid mixture
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Diego Moretti
Amino Acids, Essential, Metabolism
Impact of Amino Acids to Enhance Anabolism After Home-based Exercise
An adequate quantity of lean body mass is vital for optimal health and performance, and is accrued when net protein balance (NPB) is positive.
- Conditions
- Amino Acids, Essential, Metabolism, Exercise
- Trial name
- B2B (NCT04850820)
- Testing
- Novel essential amino acid supplementation, Branched-chain amino acid supplementation (BCAA), Isocaloric carbohydrate supplementation
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto