Clinical trials: BDNF
Irritable Bowel Syndrome
Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients
Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently.
- Trial name
- NCT00925223
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
BDNF
Daily Fluctuations in Brain-Derived Neurotrophic Factor and Cognition: Effects of Vigorous Exercise
Cognitive functions are fundamental to everyday life, underpinning the mental processes required to perform any activity. Recent studies have shown that improved cognitive performance is associated with elevated levels of…
- Trial name
- NCT07385118
- Testing
- Exercise
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Padova
Obesity
Acute Cognition and Exercise
The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults.
- Trial name
- ACE (NCT05078203)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Mood Disturbance
Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance
The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores >9.
- Trial name
- NCT06531863
- Testing
- Curcumin, Epigallocatechin Gallate
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Auburn University
Overactive Bladder
Urinary Neurotrophin Levels as Potential Biomarkers for Overactive Bladder: A Case-Control Study
Overactive bladder is a prevalent urological disorder marked by symptoms such as urinary urgency, increased frequency of urination, and nighttime urination (nocturia).
- Trial name
- urinary (NCT06563193)
- Testing
- NERVE GROWTH FACTOR
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Erzincan Binali Yildirim Universitesi
Cervicogenic Headache, Sleep Disturbance
Effect of Isometric Neck Exercises on Cervicogenic Headache Symptoms, Cortisol and BDNF Levels Among Smart Phone Users
Cervicogenic headache (CGH) is a secondary headache type caused due to refereed pain arising from the cervical spine in the forehead, sometimes in temporal region.
- Conditions
- Cervicogenic Headache, Sleep Disturbance, Stress
- Trial name
- NCT07354776
- Testing
- Isometric Neck Exercise Program, Usual Care
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Cognitive Change
An Open-label, Exploratory Study to Investigate the Efficacy of BDNF Essentials® on Cognition
The objective of this open-label, exploratory study is to investigate the efficacy of BDNF Essentials® on cognition in a healthy adult population with self-reported memory complaints.
- Trial name
- NCT04860778
- Testing
- BDNF Essentials
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Researched Nutritionals LLC
Sports Performance
Effects of L-Tyrosine and Caffeine on Performance in Elite Boxers
Participants will complete six sessions, including one familiarization and baseline session followed by five experimental conditions: control (no supplementation), placebo, L-tyrosine, caffeine, and combined L-tyrosine plus…
- Trial name
- TYCAF-BOX (NCT07530185)
- Testing
- L-Tyrosine, Caffeine, L-tyrosine + Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Inonu University
Cognition - Other, Depression, Anxiety
Effects of a Black Rice Extract and Anthocyanidin Metabolites on the Synthesis and Release of BDNF in Healthy Subjects
The goal of this clinical trial is to investigate the effect of black rice extract (BRE) supplementation on levels of BDNF, which is a key molecule in cognition in healthy volunteers.
- Trial name
- NCT06594848
- Testing
- Black rice extract
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Wellness, Psychological, Well-Being, Psychological
Impact of Levagen+® Palmitoylethanolamide (PEA) in a Cross-Over Trial Examining Stress and Cognition in University Students
The goal of this randomised cross-over trial is to learn about the effects of Levagen+® Palmitoylethanolamide (PEA) supplementation on cognition, wellness and well-being in young and healthy university students.
- Trial name
- IMPRESS (NCT06225440)
- Testing
- Levagen+® Palmitoylethanolamide (PEA)
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Westminster
BIPOLAR DISORDER
Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania
There is sound evidence that quetiapine is effective in the treatment of manic and depressive episodes associated with Bipolar Disorder (BD) (Yatham et al 2006).
- Trial name
- NCT00879632
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Fibromyalgia Syndrome
Study of Indoleamine 2,3-dioxygenase Activity, Serum Levels of Cytokines, BDNF, BH4 and Mirtazapine Efficacy in Fibromyalgia Syndrome
This study aims to investigate the anti-nociceptive biogenic amine (serotonin [5-hydroxytryptamine; 5-HT], norepinephrine [NE], dopamine [DA], and their metabolites) status, and serum levels of cytokines, BDNF and BH4 in Thai…
- Trial name
- NCT00919295
- Testing
- mirtazapine
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mahidol University
BDNF, Memory Impairment
BDNF Promoter Methylation: Effects on Cognition, Stress and Anxiety and Depression Symptom in Healthy Women.
The purpose of this study is to explore the association between BDNF methylation and neurocognitive performance, perceived stress, and well-being in healthy women.
- Conditions
- BDNF, Memory Impairment, Stress, Well-being
- Trial name
- BDNFm (NCT04955457)
- Testing
- Healthy women active teachers
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ana Flávia Marçal Pessoa
Depression
Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression
The Blue Sky Project, a 5-year study funded by the Canadian Institutes of Health Research, seeks to examine how genetics and early life experiences work together to cause a person's very first onset of depression by increasing…
- Trial name
- NCT00517764
- Testing
- escitalopram
- Where
- 2 sites in Canada
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Huntington Disease
Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have been evoked, including an alteration of the signaling…
- Trial name
- LCR-MH (NCT04012411)
- Testing
- Brain MRI, Lumbar Punction, Blood sample
- Where
- France
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bipolar
Genetic Association Study Between Single Nucleotide Polymorphisms (SNPs) and Cognitive Performance in Young Bipolar Type I Patients: LICAVALGENE
This is a genetic association study of cognitive impairment in young bipolar disease type I patients without medications in mania, depression, hypomania or mixed states.
- Trial name
- Licavalgene (NCT00969930)
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Oxidative Stress
Lithia Water Study: Effects of Lithia Water on BDNF and Oxidative Stress Markers in Healthy Male Participants
This study investigates the effects of daily use of lithia water on blood tests of neuronal oxidative stress, mood, and well-being.
- Trial name
- NCT01257867
- Testing
- Lithia water, Natural spring water with negligible lithium levels
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ketosis
Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid
It is well established that the brain is capable of consuming ketone bodies, especially during low glucose availability, e.g. fasting.
- Trial name
- KetoBrain (NCT06318299)
- Testing
- Ketone Ester
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of BCI-838 and its metabolite BCI-632 in healthy male and female subjects.
- Trial name
- NCT01548703
- Testing
- BCI-838
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BrainCells Inc.