Clinical trials: BIS
Explicit Recall of Intra-operative Events
Study Evaluating Ways of Preventing Patients From Being Awake During High-Risk Surgery and Anesthesia
The overall purpose of this study is to see if a Bispectral Index (BIS) monitor, a Food and Drug Administration (FDA) approved brain monitoring device, will help to reduce the risk of patients remembering being awake during…
- Trial name
- NCT00281489
- Testing
- BIS Monitor guided algorithm, Volatile anesthetic guided algorithm
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Washington University School of Medicine
Anesthesia
Automatic Control of Total Intravenous Anesthesia (ACTIVA)
This study concerns the clinical evaluation of a closed loop control system for the automatic administration of anesthetic drugs in TIVA (Total Intra Venous Anesthesia).
- Trial name
- ACTIVA (NCT04432974)
- Testing
- Automatic closed-loop anesthesia
- Where
- Italy
- Volunteers
- 139 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Kidney Disease
Assessment of Serum Cystatin C as a Marker of Kidney Function in Children
The purpose of this study is to assess serum cystatin C as a marker of kidney function (glomerular filtration rate, GFR) in children aged 2-14.
- Trial name
- NCT00300066
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University Hospital
General Surgery, Anaesthesia
BIS Monitoring of the Depth of Anaesthesia in Children
General anaesthesia (GA) is, according to many definitions, the greatest gift presented to the medical art (S. B. Nuland). One of the aims of GA is to achieve the optimal depth of anaesthesia and rapid emergence from general…
- Trial name
- NCT02664142
- Testing
- BIS Group, Non-BIS Group, Anaesthetics
- Where
- Czechia
- Volunteers
- 220 people
- Sponsor
- University Hospital Ostrava
Atopic Dermatitis
Twice Daily Versus Twice Weekly Soak-and-Seal Baths in Pediatric Atopic Dermatitis
There are few studies evaluating best bathing practices in the management of pediatric atopic dermatitis (AD). Trans-epidermal water loss plays a key role in the pathophysiology of AD.
- Trial name
- NCT03397979
- Testing
- Infrequent versus Frequent Soaking Baths
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Anesthesia
Evaluation of EEG With Respect to the Change of Depth of Anesthesia During General Anesthesia
The BIS Index, one of the VISTA Monitor output parameters, may be used as an aid in monitoring the effects of certain anesthetic agents;and its usage with certain anesthetic agents may be associated with a reduction in primary…
- Trial name
- NCT02586441
- Testing
- Electroencephalography, Propofol, Rocuronium bromide
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Solid Tumors
Study of STA-9090, Administered Twice-Weekly in Patients With Solid Tumors
An open-label dose escalation study of patients with solid tumors treated with STA-9090 (ganetespib)
- Trial name
- NCT00688116
- Testing
- STA 9090 (ganetespib)
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- Synta Pharmaceuticals Corp.
Surgery, Bispectral Index
Bispectral Index: A Comparison of Bifrontal Montage Agreement
The researchers are trying to compare the results of two sensors when recorded simultaneously on opposite sides of the forehead.
- Trial name
- NCT04062240
- Testing
- BIS sensor
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
EGFR-Mutant Lung Cancer
Low Dose Daily Erlotinib in Combination With High Dose Twice Weekly Erlotinib in Patients With EGFR-Mutant Lung Cancer
The purpose of this study is to test the safety of different ways of taking erlotinib. The investigators want to find out what effects, good and/or bad, combination daily low dose and twice weekly high dose erlotinib has on the…
- Trial name
- NCT01967095
- Testing
- erlotinib
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hydrocephalus
BIS Monitoring of Patients With Hydrocephalus
We tested the hypothesis that BIS values are altered in pediatric patients with hydrocephaly. We also tested the hypothesis that BIS values are altered in adult post cerebral hemorrhage patients with hydrocephaly undergoing…
- Trial name
- BIS1 (NCT02575105)
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Chronic Kidney Disease
Association of Diuretics With Change in Extracellular Volume, Natriuretic Peptides, Symptoms, and Cardiovascular Outcomes in CKD
Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes.
- Trial name
- DOCK (NCT04192110)
- Testing
- Diuretic initiation or augmentation
- Where
- United States
- Sponsor
- VA Office of Research and Development
Anesthetics
A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values
The aim of this study is to determine whether induction of anesthesia with thiopental followed by propofol infusion is able to maintain sufficient depth of anesthesia .
- Trial name
- NCT01140100
- Testing
- propofol, thiopental,propofol
- Where
- Iran
- Volunteers
- 82 people
- Sponsor
- Shiraz University of Medical Sciences
General Anesthesia With Propofol, Closed-Loop
Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine
The propofol-remifentanil closed-loop TCI system based on EEG guidance has been clinically verified, which enables more precise anesthetic dosing.
- Trial name
- NCT06729892
- Testing
- Esketamine at low dose, new BIS baseline, an equivalent dose of saline
- Volunteers
- 120 people
- Sponsor
- bo xu
Electroencephalography, Craniotomy Surgery
Evaluation of Response to Pain From Skull Pin Fixation in Craniotomies
The goal of this observational study is to investigate the relationship between the response to skull pin fixation pain and the analysis of blood pressure, heart rate, and brain wave activity in adults undergoing brain surgery.
- Conditions
- Electroencephalography, Craniotomy Surgery, Pain Management
- Trial name
- NCT06811701
- Testing
- Scalp nerve block, Opioid Anesthetics, Local Anesthetic Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Movement Disorders, Depth of Anesthesia Monitors
BIS and Entropy in Deep Brain Simulation
The main objective of the study is to determine whether depth of anesthesia (DOA) monitoring such as Bispectral Index (BIS) and entropy are accurate in patients with neuro-psychological conditions such as Parkinson's disease by…
- Trial name
- NCT02386995
- Testing
- BIS monitor, Entropy monitor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Rheumatoid Arthritis
Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis (RA) Subjects Who Are Sub-Optimal Responders to Etanercept 50 mg Once Weekly (QW)
The purpose of this study objective will be to evaluate the efficacy and safety of etanercept 50 mg BIW in RA subjects who showed a sub-optimal response to standard dose etanercept (50 mg QW) and concomitant methotrexate therapy.
- Trial name
- NCT00115219
- Testing
- Etanercept
- Volunteers
- 200 people
- Sponsor
- Amgen
Unspecified Adult Solid Tumor, Protocol Specific
Mistletoe Lectin in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy
RATIONALE: Mistletoe lectin may slow the growth of cancer cells and be an effective treatment for solid tumors. PURPOSE: Phase I trial to study the effectiveness of mistletoe lectin in treating patients who have advanced solid…
- Trial name
- NCT00006354
- Testing
- mistletoe extract
- Where
- 2 sites in France, Germany
- Volunteers
- 41 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Common Wart
Study of A-101 Topical Solution for the Treatment of Common Warts
A Phase 3 Study of A-101 Topical Solution Applied Twice a Week in Subjects with Common Warts
- Trial name
- NCT03687372
- Testing
- A-101, vehicle
- Where
- 24 sites in United States
- Volunteers
- 503 people
- Sponsor
- Aclaris Therapeutics, Inc.