Clinical trials: BIS, open to volunteers
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Depth of Anesthesia Monitoring, BIS-EEG
The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia
This prospective, single-center, randomized interventional study aims to investigate the effects of commonly used adjunct anesthetic drugs on the Bispectral Index (BIS) and electroencephalographic (EEG) activity during total…
- Trial name
- NCT07699523
- Testing
- Midazolam, Dexmedetomidine, Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Disorders of Consciousness, Vegetative State
AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness
Disorders of consciousness (DoC) are severe neurological conditions characterized by impaired awareness and reduced interaction with the environment.
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- AI-HBOT-DoC (NCT07855848)
- Testing
- AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Depression - Major Depressive Disorder, Cognitive Behavior Therapy
Mechanisms Of Change in Psychotherapy: The Effects of Cognitive Behavioral Therapy and Psychodynamic Therapy in Once - Versus Twice - Weekly Sessions on Outcomes in Depression.
The MOP II study examines how to improve therapy for people struggling with a depressive disorder. Cognitive Behavioral Therapy (CBT) and Short-Term Psychodynamic Psychotherapy (STPP) are two evidence-based treatments for…
- Conditions
- Depression - Major Depressive Disorder, Cognitive Behavior Therapy, Psychodynamic Therapy
- Trial name
- MOP II (NCT07408687)
- Testing
- Cognitive behavior therapy, Psychodynamic therapy
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Oslo
Critically Ill Patients
BIS in Critically Ill Patients in ICU
The Bispectral Index (BIS) is a monitor that converts brain electrical activity from EEG into a simple number from 0 to 100. A higher number means the patient is more awake, while a lower number means deeper sedation or reduced…
- Trial name
- NCT07583732
- Testing
- Processed EEG monitoring
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Short Bowel Syndrome
Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS
The purpose of the present Phase 3 trial is to confirm the efficacy and safety of glepaglutide 10 mg twice weekly in a patient population with SBS-IF and generate additional long-term safety data.
- Trial name
- EASE SBS 5 (NCT07197944)
- Testing
- Glepaglutide
- Where
- 33 sites in United States, Austria and 12 more
- Volunteers
- 90 people
- Sponsor
- Zealand Pharma
ıntraoperative Cerebral Oxygenation, Cerebral Oxygenation Monitoring
Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation in Patients Undergoing Laparoscopic Cholecystectomy
Study Population: Patients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included. Study Design: This is an observational study.
- Trial name
- NCT07517146
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Renal Failure Acute Chronic
Bispectral-Electroencephalography (EEG) in First Time Hemodialysis
The severity of minimal dialysis disequilibrium syndrome (DDS) is currently detected and graded clinically using clinical criteria.
- Trial name
- BIS7 (NCT03276273)
- Testing
- recording of Bispectral Index
- Where
- 2 sites in China, Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Dilated Cardiomyopathy (DCM), Cardiovascular Diseases
BAG3-DCM Natural History Study
The goal of this international observational study is to learn about the natural history of Dilated Cardiomyopathy (DCM) arising from pathogenic BAG3 variants in adult patients ≥18 years of age.
- Conditions
- Dilated Cardiomyopathy (DCM), Cardiovascular Diseases, Heart Diseases, Genetic Diseases
- Trial name
- NCT07486752
- Volunteers
- 30 people
- Sponsor
- Rocket Pharmaceuticals Inc.
BAG3 Mutation Associated Dilated Cardiomyopathy
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy
This Phase 1/2 study is an open-label, dose finding and dose expansion study investigating the safety, tolerability, and efficacy of a single IV infusion of ALXN2350 in adult participants with BAG3 associated DCM.
- Trial name
- DCMRestore (NCT07218887)
- Testing
- ALXN2350
- Where
- 11 sites in United States, Italy and 2 more
- Volunteers
- 6 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Type 1 Diabetes
A Trial of Three- and Seven-days Insulin Infusions Set
More and more children and adolescents are using diabetes devices attached to the skin. The attachment of infusions sets to the skin provoke allergenic or toxic eczema, the continous infusion of insulin provoke subcutaneous…
- Trial name
- NCT06532461
- Testing
- Mio Advanced infusions set, Novorapid, Extended wear insulin infusion (EWIS)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Steno Diabetes Center Copenhagen
Sepsis, Severe
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis
To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
- Trial name
- BIS6 (NCT03244293)
- Testing
- no intervention
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Emergence Delirium, Anesthesia
The Effect of EEG and BIS-guided Anaesthesia on the Incidence of Emergent Delirium in Children
The aim of the study is to compare two modalities of measuring the depth of general anaesthesia on the incidence of emergent delirium in children.
- Trial name
- NCT07534215
- Testing
- EEG monitoring, BIS monitoring
- Where
- Czechia
- Volunteers
- 540 people
- Sponsor
- University Hospital Ostrava
Age Problem, Dialysis; Complications
Twice vs Thrice Weekly Incident Hemodialysis in Elderly Patients
As Korea is becoming a super-aged society, the number of elderly patients with end-stage kidney disease (ESKD) is expected to increase rapidly. Therefore, the burden on Korean society will also increase.
- Conditions
- Age Problem, Dialysis; Complications, Frailty, Quality of Life
- Trial name
- NCT06141798
- Testing
- Hemodialysis
- Where
- 7 sites in South Korea
- Volunteers
- 428 people
- Sponsor
- Soonchunhyang University Hospital
Dilated Cardiomyopathy (DCM), BAG3 Mutation Associated Dilated Cardiomyopathy
An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM)
This is a Phase 1/2, open-label, dose-exploration and dose-expansion, clinical trial evaluating the safety, tolerability, pharmacodynamics, and preliminary efficacy of a single intravenous infusion of AFTX-201 in adults with…
- Trial name
- UPBEAT (NCT07426419)
- Testing
- AFTX-201
- Where
- 5 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Affinia Therapeutics
Pancreatic Adenocarcinoma Non-resectable
A First-in-Human Study to Evaluate Implantable Iontophoresis Chemotherapy Delivery Device With Gemcitabine Once Weekly or Twice Weekly in Participants With Pancreatic Cancer
This study is being done to find out if delivering gemcitabine using the ACT-IOP-003 device directly to the area where the tumor is in the pancreas is safe and tolerable.
- Trial name
- NCT07481383
- Testing
- ACT Implantable Iontophoresis Chemotherapy Delivery Device with Gemcitabine (ACT-IOP-003)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Continuity Biosciences, LLC
Hemodialysis
Bioimpedance Spectroscopy (BIS): Fluid Changes in Hemodialysis Patients
In connection with dialysis treatment, fluid and salt balance changes. Some kidney disease patients experience fluid accumulation in the body and need to have excess fluid removed via the dialysis machine.
- Trial name
- NCT07803029
- Testing
- Bioimpedance analysis
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Per Ivarsen
Cardiac Surgical Procedures (Postoperative Population), Critical Illness
BIS in ICU Interventional Study
This study will test whether using a Bispectral Index (BIS) monitor to guide sedation can reduce the amount of sedative medication given to adults in the intensive care unit (ICU) after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures (Postoperative Population), Critical Illness, Postoperative Complications (Cardiopulmonary), Delirium - Postoperative
- Trial name
- NCT07350122
- Testing
- Device-guided sedation, standard sedation practice
- Volunteers
- 144 people
- Sponsor
- Medical University of Graz
Acute Decompensation of Liver Cirrhosis, Established Acute-on-Chronic Liver Failure
Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure
Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients with Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure
- Trial name
- CONTROL-ACLF (NCT07694297)
- Testing
- NTZ 500mg BID on top of SOC
- Volunteers
- 16 people
- Sponsor
- Genfit
Lymphoedema
Subclinical Monitoring of Lymphatic Function in Oncology Patients for Lymphoedema Prevention (ONCOLYMPH)
Lymphoedema, a chronic condition caused by the accumulation of protein-rich fluid in the intercellular spaces due to impaired lymphatic function, is a common complication in cancer patients.
- Trial name
- ONCOLYMPH (NCT07011316)
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- The Greater Poland Cancer Centre