Clinical trials: BOS
Other Cancer
Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation (HCT)
This research study is studying a drug as a possible treatment for Bronchiolitis Obliterans Syndrome (BOS) after having an Allogeneic Hematopoietic Cell Transplantation (HCT).
- Trial name
- NCT03674047
- Testing
- ruxolitinib
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Bronchiolitis Obliterans
Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS)
The purpose of this study is to evaluate long-term safety of L-CsA in prevention of bronchiolitis obliterans syndrome (BOS) following lung transplantation (LTx) in patients previously enrolled in phase II/III L-CsA clinical trial…
- Trial name
- NCT01439958
- Testing
- Inhalation
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Pari Pharma GmbH
Asthma, COPD
Evaluation of 3D Magnetic Resonance Spirometry: Comparison with Spirometry in Healthy Subjects and Patients with Respiratory Pathologies (asthma, COPD, Bilateral Lung Transplant)
Spirometry is now the gold standard technique for assessing lung function in humans. From the shape of a flow-volume curve measured while the patient, trained by the practitioner, performs forced breaths, the forced vital…
- Conditions
- Asthma, COPD, BOS
- Trial name
- gb-Spiro3D (NCT05724745)
- Testing
- 1. Standard spirometry, 2. 3D dynamic lung MRI at UTE in prone and supine positions, 3. Reversibility test with salbutamol
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Commissariat A L'energie Atomique
Chronic Rejection in Lung Transplant, Cytokine Production in Bos Post Lung Transplant
Early Indicators of Chronic Rejection in Lung Transplant
The purpose of this research is to discover the different patterns of cytokine production in patients who may develop Bronchiolitis Obliterans Syndrome-0p (BOS-0p) which means ongoing rejection.
- Trial name
- BOS (NCT00449332)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Bronchiolitis Obliterans Syndrome (BOS), GVHD, Chronic
A Safety Study of Liposomal Cyclosporine A to Treat Bronchiolitis After Hematopoietic Transplant (BOSTON-4)
Primary Objective: The primary objective of this study is to assess the tolerability and safety of two dose levels of aerosolized L-CsA vs placebo in addition to SoC therapy for BOS in adult allo-HSCT recipients.
- Conditions
- Bronchiolitis Obliterans Syndrome (BOS), GVHD, Chronic, Stem Cell Transplant Complications
- Trial name
- BOSTON-4 (NCT04107675)
- Testing
- Liposomal Cyclosporine A
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 6 people
- Sponsor
- Zambon SpA
Bronchiolitis Obliterable Syndrome
Forced Oscillatory Technique for Bronchiolitis Obliterans Syndrome After Allogeneic Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS) is a severe pulmonary complication following allogeneic hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT07730931
- Testing
- FOT - Forced Oscillation Technique
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Hadassah Medical Organization
Posttraumatic Stress Disorder, Depression
Randomized Controlled Trial of the Effectiveness of Group Treatment With War-Exposed Bosnian Adolescents
Context: This is the first multi-site randomized controlled study of the effectiveness of a group treatment for war-exposed adolescents delivered in-country within a public school system.
- Conditions
- Posttraumatic Stress Disorder, Depression, Grief (Traumatic Grief and Existential Grief)
- Trial name
- NCT00480480
- Testing
- Trauma and Grief Component Therapy for Adolescents (Group Version)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Bronchiolitis Obliterans Syndrome
Imaging and Understanding BOS in Lung Transplantation
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.
- Trial name
- NCT02316392
- Testing
- Hyperpolarized Helium-3 MRI
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bronchiolitis Obliterans Syndrome (BOS), Bronchiolitis Obliterans (BO)
Nintedanib in Patients With Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem Cell Transplantation
This study investigates the safety and tolerability of Nintedanib in patients with bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic cell transplantation.
- Trial name
- NINBOST2018 (NCT03805477)
- Testing
- Nintedanib
- Where
- 3 sites in Saudi Arabia, Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
Bronchiolitis Obliterans, Sleep Disordered Breathing Central
Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3
This study is to determine whether sleep disorders contribute to impaired quality of life and mobility in patients with Bronchiolitis Obliterans syndrome and whether non invasive positive airways pressure ventilation can improve…
- Trial name
- NCT02109237
- Testing
- Assessment of sleep disorders and treatment if required
- Where
- Australia
- Sponsor
- The Prince Charles Hospital
Rheumatoid Arthritis
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)
This open-label, single arm study will assess the safety and efficacy of RoActem ra/Actemra (tocilizumab) in combination with methotrexate in patients with activ e moderate to severe rheumatoid arthritis who have an inadequate…
- Trial name
- NCT01235507
- Testing
- methotrexate, tocilizumab [RoActemra/Actemra]
- Where
- 3 sites in Bosnia and Herzegovina
- Volunteers
- 71 people
- Sponsor
- Hoffmann-La Roche
Complication of Transplanted Lung
Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS)
This study is a pilot two- center study to determine if aztreonam lysine for inhalation AZLI can be safely and self-administered in lung transplant recipients with newly diagnosed bronchiolitis obliterans syndrome, grade 1 (BOS)…
- Trial name
- AZLI (NCT01469364)
- Testing
- Aztreonam Lysine for Inhalation (AZLI), Status Post Lung Transplant
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Bronchiolitis Obliterans, Graft Vs Host Disease
The Safety and Tolerability of Pirfenidone for BOS After HCT
This is a phase 1, non-randomized, single-arm, open label, single center clinical trial to determine the tolerability and safety of pirfenidone in patients with BOS associated with lung GVHD after hematopoietic cell transplant.
- Trial name
- STOP-BOS (NCT03315741)
- Testing
- Pirfenidone 267 MG [Esbriet]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
COPD, Emphysema
Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant
The study will evaluate the efficacy and safety of basiliximab Vs placebo as induction therapy combined with standard triple immunosuppression therapy, in the prevention of acute rejection episodes and prevention of Bronchiolitis…
- Conditions
- COPD, Emphysema, Alpha-1 Antitrypsan Deficiency
- Trial name
- NCT00188825
- Testing
- basiliximab
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic rejection.
- Conditions
- Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans, Extracorporeal Photopheresis
- Trial name
- NCT07434869
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brian Keller
Lung Transplantation, Bronchiolitis Obliterans Syndrome
Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
Chronic organ dysfunction after lung transplantation (BOS) is the most common cause of death in long-term survivors after lung transplantation and refractory to most interventions.
- Trial name
- NCT00774449
- Where
- Germany
- Volunteers
- 261 people
- Sponsor
- Hannover Medical School
Bronchiolitis Obliterans Syndrome (BOS), HSCT
Efficacy of an Anti-TSLP Monoclonal Antibody in the Management of Chronic Bronchial Disease Induced by Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Stem Cells Transplantation Recipients
Allogeneic hematopoietic stem cell transplantation (HSCT) is burdened with a high morbidity and mortality rates. Graft versus host disease (GVHD) is the clinical manifestation of an immune conflict.
- Conditions
- Bronchiolitis Obliterans Syndrome (BOS), HSCT, Bronchial Disease
- Trial name
- IMMUNO-BOS (NCT07771855)
- Testing
- Tezepelumab
- Where
- 6 sites in France
- Volunteers
- 36 people
- Sponsor
- Hopital Foch
Bronchiolitis Obliterans, Lung Transplant Rejection
Prospective Study for Transplant Optimization Using Functional Imaging (TROFI)
The objective of this study is to detect BOS in an early stage by using the outcome parameters generated by Functional Respiratory Imaging (FRI).
- Trial name
- NCT02488304
- Testing
- HRCT scans
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- FLUIDDA nv
Graft Versus Host Disease (GVHD), Acute Myocardial Infarction (AMI)
University of Wisconsin hMSC Cell Bank: Bone Marrow Donor Protocol
The objective of this protocol is to use established standard criteria and methods for the collection of hMSC (human mesenchymal stromal cells) from healthy bone marrow donors.
- Trial name
- NCT01463475
- Testing
- Bone marrow aspirate
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Bronchiolitis Obliterans
Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant
This phase I trial studies how well itacitinib works for the treatment of bronchiolitis obliterans syndrome after donor hematopoietic cell transplant.
- Trial name
- NCT04239989
- Testing
- Itacitinib, Itacitinib Adipate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center