Clinical trials: BRONCHIAL ASTHMA
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
A Thorough QT (TQT) Study of CHF5993 pMDI in Healthy Volunteers (HV)
The purpose of this study is to evaluate the potential for cardiac repolarization, according to electrocardiographic monitoring (including QT and QTc intervals), of two dose levels of CHF5993 pMDI (beclomethasone…
- Trial name
- NCT05830071
- Testing
- CHF5993, CHF5259, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma, Children
Reduction of Asthma Exacerbation Rate in Children by Non-invasive Monitoring of Inflammatory Markers in Exhaled Breath (Condensate): the RASTER Study
The purpose of the present proposal was to investigate the predictive properties of markers in exhaled breath to predict an asthma exacerbation.
- Conditions
- Asthma, Children, Home Monitoring, Exhaled Breath Condensate
- Trial name
- RASTER (NCT01239238)
- Where
- 2 sites in Netherlands
- Volunteers
- 102 people
- Sponsor
- Maastricht University Medical Center
Asthma, Lung Diseases
Isocyanate Antigens and T Cells That Cause Asthma
To investigate whether isocyanate-induced asthma is dependent on isocyanate antigen-driven T-cell mediated, airway inflammation.
- Trial name
- NCT00005549
- Sponsor
- Yale University
Asthma
Study on the Effects of an AMP Challenge on Asthmatic Patients Following Treatment With Fluticasone Propionate
Inhaling AMP causes an inflammatory response in the lung. This study will investigate whether 5-days of treatment with fluticasone propionate protects the lung from responding to the AMP in this way.
- Trial name
- NCT00400855
- Testing
- Fluticasone propionate
- Where
- 2 sites in New Zealand
- Volunteers
- 49 people
- Sponsor
- GlaxoSmithKline
Aspirin-exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps
Effects of a High or Low Salycilate Diet on Urinary LTE4 and Clinical Features in AERD
On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting.
- Conditions
- Aspirin-exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps, Samter's Syndrome, Widal Syndrome
- Trial name
- AERD (NCT03973749)
- Testing
- Low salycilate diet
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Asthma Chronic, Bronchial Asthma
Effect of Chromium Weight Reduction on Adult Asthma Control
This phase IV randomized controlled trial is designed to evaluate the effects of chromium picolinate supplementation in obese adults with stable asthma.
- Trial name
- ECWAC (NCT07703358)
- Testing
- Chromium picolinate
- Volunteers
- 60 people
- Sponsor
- Cairo University
Asthma
Evaluation of Negative Inspiratory Flow in Children With Acute Asthma
There are different inhalers used for the treatment of asthma and they work differently and require different technique for the optimal drug delivery to the lungs. One of the inhalers is the Dry Powder Inhaler (DPI).
- Trial name
- NCT05762978
- Testing
- In-Check Dial, Inhaler Device
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Asthma
Genetic Susceptibility to Childhood Respiratory IIlness in Mexico City
We propose to add a collection of genetic material to a clinical trial of anti-oxidant supplementation for the amelioration of asthma in 7-12 year olds being conducted at a public pediatric hospital in Mexico City.
- Trial name
- NCT00339521
- Where
- Mexico
- Volunteers
- 2,362 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma
Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of GSK2292767 in Healthy Participants Who Smoke Cigarettes
This study is the first administration of GSK2292767 to humans. The study will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single and repeat inhaled doses of GSK2292767 in healthy…
- Trial name
- NCT03045887
- Testing
- GSK2292767 50 μg, GSK2292767 500 μg
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
Influence of Diesel Exhaust Particles (DEP) With and Without Organic Compounds on the Allergic Inflammation in Asthmatic Subjects
The primary objective of this study is to elucidate the effects of Diesel particles on the allergic inflammation in the airways of asthmatic patients.
- Trial name
- NCT00773487
- Testing
- Bonchoscopy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Asthma in Children, Status Asthmaticus
BPAP in Pediatric Asthma Pilot Study
The investigators aim to study the effect and safety of bilevel positive airway pressure (BPAP) in children with moderate to severe asthma exacerbations - by examining the effects of early initiation of BPAP in pediatric patients…
- Trial name
- NCT04656587
- Testing
- Philips Respironics V60 Non-invasive ventilator, BPAP, Standard Therapy
- Sponsor
- Columbia University
Asthma
Repeat Dose Safety Study for Compound to Treat Asthma
The purpose of this study is to describe the safety and tolerability of single and repeat oral doses of GSK1440115 in healthy volunteers.
- Trial name
- NCT01202214
- Testing
- 1440115
- Where
- Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Accenture
Asthma
A Pilot Evaluation of the Impact of Alcohol Use on Airway Inflammation and Mechanics in Asthmatics
Since 1980, the number of people in the United States diagnosed with asthma has increased dramatically. Studying what causes and triggers asthma is an important part of understanding and subsequently managing this disease.
- Trial name
- AIM Asthma (NCT00615407)
- Sponsor
- Emory University
Asthma
Oral Nadolol for the Treatment of Adults With Mild Asthma
The purpose of this study is to confirm previous observations in asthmatics that chronic nadolol treatment reduces asthmatic airway hyper-responsiveness.
- Trial name
- NCT00670267
- Testing
- nadolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Invion, Inc.
Obesity, Asthma
Evaluation of the Effectiveness of Standard and Innovative Products That Represent a Substitute Meal for Weight Management in a Reduction Diet in Obese Participants With Asthma
Randomized stratified controlled clinical study for evaluate the effectiveness of a diet program designed for reduce body weight through standard and innovative products that are a substitute meal for weight management in a…
- Conditions
- Obesity, Asthma, Overweight
- Trial name
- NCT05980663
- Testing
- Meal replacement product- STANDARD PRODUCT, Meal replacement product- INNOVATIVE PRODUCT
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Srebrnjak
Asthma
The Asthma Bronchial Challenge Study
This is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (VOCs) in the exhaled breath of adults with well-controlled, mild-to-moderate…
- Trial name
- ABC (NCT03575663)
- Testing
- Indirect bronchial challenge
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Asthmatic
Influenza Vaccine Feasibility Study in Children With Persistent Asthma
This study is designed to note whether a larger safety study using quadrivalent live attenuated influenza vaccine (LAIV4) versus quadrivalent inactivated influenza vaccine (IIV4)(FLUARIX®), would be feasible in children with…
- Trial name
- NCT02967393
- Testing
- ccIIV4, IIV4
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Allergic Bronchial Asthma
c9,t11-CLA in Children and Adolescents With Allergic Asthma
The study was performed to investigate the effects of a dietary intervention with c9,t11-CLA on clinical and immunological parameters in children and adolescents with allergic bronchial asthma.
- Trial name
- NCT01026506
- Testing
- conjugated linoleic acid
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University of Jena
Asthma
A Study of MK0359 in Patients With Chronic Asthma (0359-013)
A study to test the effect of MK0359 in lessening the symptoms of asthma as compared to placebo.
- Trial name
- NCT00482898
- Testing
- MK0359
- Volunteers
- 56 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma
This is a Phase 1b, single center study designed to evaluate the efficacy, safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of GSK3923868 following repeat doses in mild asthmatics during experimental human…
- Trial name
- NCT05398198
- Testing
- GSK3923868
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- GlaxoSmithKline
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