Clinical trials: BRONCHIAL ASTHMA
Asthma
Airway Hyper-responsiveness Study In Asthma Using Salmeterol/Fluticasone Propionate Combination Product
This double-blind, stratified, parallel group study is to determine whether aiming for 'Total control' results in better airway hyper-responsiveness than maintaining the treatment level at which 'Well-controlled' asthma was…
- Trial name
- NCT00291382
- Testing
- Salmeterol/fluticasone propionate combination
- Where
- 35 sites in Belgium, Estonia and 8 more
- Volunteers
- 150 people
- Sponsor
- GlaxoSmithKline
Asthma
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)
This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care
- Trial name
- KALOS (NCT04609878)
- Testing
- BGF MDI 320/28.8/9.6 μg, BGF MDI 320/14.4/9.6 μg, BFF MDI 320/9.6 μg
- Where
- 360 sites in United States, Argentina and 19 more
- Volunteers
- 2,274 people
- Sponsor
- AstraZeneca
Rhinitis, Asthma
The Safety and Efficacy of Intralymphatic Immunotherapy in Pollen Allergic Adolescents and Young Adults With Asthma
The study evaluates the safety and efficacy of intralymphatic allergen-specific immunotherapy given to adolescents and young adults who are allergic to grass or birch pollen and have mild or moderate asthma.
- Conditions
- Rhinitis, Asthma, Allergy
- Trial name
- NCT03394508
- Testing
- ALK Alutard birch or 5-grasses, ALK diluent 0,3% human albumin
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Asthma
QUARTZ: Comparative Effectiveness of Switching From Albuterol to Albuterol/Budesonide Versus Adding Low-dose ICS or LTRA to Albuterol
The QUARTZ study is a retrospective observational cohort study using a prevalent new-user design and U.S. healthcare claims data to evaluate treatment effectiveness among patients with asthma.
- Trial name
- QUARTZ (NCT07787117)
- Testing
- None (observational study)
- Where
- United States
- Volunteers
- 8,681 people
- Sponsor
- AstraZeneca
Dental Caries, Periodontal Diseases
Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic Rhinitis
The aim of the study is to compare the incidence of dental caries and the level of demineralization in pediatric patients with asthma and/or allergic rhinitis. Patients will conduct professional oral hygiene at the baseline.
- Trial name
- NCT05631197
- Testing
- Biorepair Total Protection Plus + desensitizing enamel-repair shock treatment, Sensodyne Repair & Protect
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Asthma
Safety Study of the Effects of Inhaled Fluticasone Furoate/GW642444 on the Hypothalamic-Pituitary-Adrenal (HPA) Axis
The purpose of this study is to assess the effect of six weeks' treatment with two once-daily strengths of Fluticasone Furoate/GW642444 Inhalation Powder on the HPA axis system
- Trial name
- NCT01086410
- Testing
- Fluticasone Furoate/GW642444 Inhalation Powder, Prednisolone Oral Capsule
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 185 people
- Sponsor
- GlaxoSmithKline
Asthma
Clinical Study to Explore the Efficacy of ACT-129968 in Patients With Partly Controlled Asthma
This study will assess the efficacy and safety of ACT-129968 in subjects with partly controlled asthma on reliever therapy only.
- Trial name
- CONTROL (NCT01225315)
- Testing
- Setipiprant
- Where
- 97 sites in United States, Australia and 11 more
- Volunteers
- 438 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Asthma
Efficacy and Safety of Flutiform K-haler in Patients With Uncontrolled Asthma Following Mid-dose ICS/LABA DPI Therapy
The purpose of this study is to evaluate the efficacy of the Asthma improvement of Flutiform K-haler after 12 weeks of treatment in patients with moderate to severe uncontrolled* asthma following mid-dose ICS/LABA DPI therapy.
- Trial name
- SWIFT (NCT04124510)
- Testing
- Brand Name: Flutiform K-haler
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Mundipharma Korea Ltd
Asthma
Predicting the Response to Montelukast by Genetic Variation in Asthmatics
The purpose of this study is to examine a specific variation in the genetic code for an enzyme (LTC4 synthase) which plays an important role in the airway inflammation associated with asthma.
- Trial name
- NCT00116324
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Asthma
Effect of OMT on Asthma Symptoms in Southwest Virginia
There is a high prevalence of asthma in southwest Virginia and there are multiple osteopathic manipulative techniques (OMT) which are thought to improve lung function.
- Trial name
- NCT00545376
- Testing
- Osteopathic Manipulative Treatment - in clinic, Osteopathic Manipulative Treatment - at home, Education to physicians
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Asthma
Pharmacokinetic Profile of Four Formulations of Fluticasone Furoate (FF) Using Unit Dose Dry Powder Inhaler (UD-DPI) Compared With FF ELLIPTA® Presentation
This is an open-label, five- period, cross-over, randomized, single dose, single centre study in healthy subjects. This is the second clinical study for the UD-DPI.
- Trial name
- NCT02218723
- Testing
- FF UD-DPI, FF ELLIPTA DPI
- Where
- 2 sites in Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
Efficacy, Safety and Pharmacokinetics of Indacaterol Acetate in Patients With Persistent Asthma
To provide the efficacy, safety and pharmacokinetics of indacaterol acetate in patients with persistent asthma to support dose selection of indacaterol in fixed dose combination QMF149.
- Trial name
- NCT01609478
- Testing
- indacaterol, mometasone furoate
- Where
- 96 sites in Bulgaria, Canada and 6 more
- Volunteers
- 335 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Improving Asthma Outcomes Through Spirometry Distance Learning
Spirometry is a recommended component of asthma diagnosis and treatment in the primary care setting, yet few providers report its routine use for children with asthma.
- Trial name
- NCT01168635
- Testing
- Spirometry 360 program - Virtually-delivered spirometry quality improvement program
- Where
- 4 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Asthma
FeNO After Hypoxia in Asthma Patients
Stable Asthma patients (GINA 1-2) stay 6 days in a row for 4 hours per day in a hypoxic chamber simulating 2800m above sea level.
- Trial name
- NCT02391090
- Testing
- hypoxia in hypoxic chamber, Pulse oximetry, Asthma and Quality of Life Questionnaires
- Where
- Austria
- Volunteers
- 21 people
- Sponsor
- Medical University of Graz
Aerosol Therapy, Asthma
Evaluation of Time-Sensitive Nebulization Mode Converter
This study utilizes a randomized crossover design to evaluate and compare the clinical and technical efficacy of different nebulization modes for aerosol drug delivery.
- Trial name
- NCT07633223
- Testing
- Cross-over Nebulization Modes Comparison System
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Asthma, Aspirin-Induced
Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD)
The purpose of this phase 2 study is to assess the safety and efficacy of oral ifetroban for the treatment of aspirin-exacerbated respiratory disease (AERD).
- Trial name
- NCT03028350
- Testing
- Ifetroban Oral Capsule
- Where
- 16 sites in United States
- Volunteers
- 54 people
- Sponsor
- Cumberland Pharmaceuticals
Asthma
Evaluating Effects of Curcumin in Moderate to Severe Asthmatics
The purpose of this investigator-initiated study is to evaluate the effects of oral curcumin supplementation versus placebo in adult patients with moderate to severe asthma.
- Trial name
- NCT04353310
- Testing
- Curcumin
- Sponsor
- Loma Linda University
Asthma
Bronchodilatation Effects of a Small Volume Spacer Used With a Metered-Dose Inhaler
The purpose of the present study is to determine whether use of a small volume spacer is associated with better bronchodilatation in an unselected population of patients with documented reversible airflow limitations.
- Trial name
- MDI (NCT00465413)
- Testing
- Small volume spacer and/or Rinsing the mouth with water
- Where
- 2 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- Mackay Memorial Hospital
Other Preterm Infants, Vitamin D Deficiency
The Effect of Vitamin D Administration to Premature Infants on Vitamin D Status and Respiratory Morbidity
This trial objective is to assess whether doubling the daily intake of vitamin D improves serum vitamin D levels and serves as primary prevention of respiratory infections and asthma in premature infants.
- Conditions
- Other Preterm Infants, Vitamin D Deficiency, Bronchiolitis, Asthma
- Trial name
- NCT02404623
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
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