Clinical trials: Bacteria
Helicobacter Pylori Infection, Intestinal Bacteria Flora Disturbance
Fucoidan Assisted Eradication of Helicobacter Pylori
The purpose of this study is to investigate whether the eradication rate of H.pylori will be improved when adding fucoidan to the duplex scheme combination of amoxicillin and vonoprazan, and to explore the effect of fucoidan on…
- Trial name
- NCT05461508
- Testing
- Amoxicillin combined with vonoprazan and fucoidan, Amoxicillin combined with vonoprazan
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Dental Caries
Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children.
The purpose of this study is to evaluate the efficacy of probiotic products on caries-associated salivary bacterial counts (Streptococcus mutans and Lactobacillus) and its effect on dental plaque accumulation in a group of…
- Trial name
- NCT02692625
- Testing
- (L. reuteri Prodentis®).
- Where
- Saudi Arabia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Cross Infection, Carbapenem Resistant Bacterial Infection
Epidemiological Features of Emergent Highly Resistant Bacteria in Tunisian Intensive Care Units
Investigate the epidemiology, risk factors and impact on clinical practice of healthcare-associated infections with emergent highly drug-resistant (eHDR) pathogens, particularly carbapenem resistant enterobacteriaceae and…
- Conditions
- Cross Infection, Carbapenem Resistant Bacterial Infection, Vancomycin-Resistant Enterococcal Infection, Critical Illness
- Trial name
- NOSOREA3 (NCT06392568)
- Testing
- epidemiological records
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- Abderrahmane Mami Hospital
Allogeneic Peripheral Blood Stem Cell Transplant
Effects of Stem Cell Transplantation on Bacteria in the Mouth
This study will examine bacteria in patients mouths at different times during stem cell transplantation and recovery. Drugs patients receive as part of the conditioning process for a stem cell transplant increase their risk of…
- Trial name
- NCT00476450
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chlorhexidine, Ventilator Associated Pneumonia
Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher…
- Trial name
- NCT03442023
- Testing
- Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12%
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Universidad de Guanajuato
Appetite; Lack or Loss, Nonorganic Origin
Encapsulated Nutrients' Acute Effects on Appetite; ENcapsulated, lipiD, aminO, pRobiotic, SatiEty
A double-blind, randomized crossover design with five arms including four experimental conditions and placebo will be applied. After having successfully completed screening procedures, eligible participants will be invited to…
- Trial name
- ENDORSE (NCT03080909)
- Testing
- Encapsulated nutrients
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Arne Astrup
Healthy
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
Gut microbiota produce different metabolites within the human body, which include neurotransmitters. Animal studies have demonstrated a critical role for the gut microbiota in various aspects of brain and behavioural function…
- Trial name
- GutBrainGABA (NCT05698862)
- Testing
- Probiotic
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Colorectal Neoplasms
Study of Fecal Bacteria in Early Diagnosis of Colorectal Cancer
The aim of the study is to identify and verify one or more gut bacteria of which the abundance in feces may help to early diagnosis colorectal cancer.
- Trial name
- NCT02845973
- Testing
- gut microbiota
- Where
- China
- Volunteers
- 1,325 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Bacteria Infection Mechanism
Cryptic Bacteria of the Thyroid Tissue as a Possible Cause of the Pathology of This Organ
The presence of cryptic microbes has been widely documented in animal healthy deep tissues. The thyroid gland is an organ specifically exposed to the microbial environment due to its close location to the mouth microbiome.
- Trial name
- NCT04552496
- Where
- 2 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Centre of Postgraduate Medical Education
Bacterial Infections
New Antibiotic to Treat Pediatric Patients With Infections Due to a Specific Bacteria (Vancomycin-Resistant Enterococcus)
This study will treat pediatric patients who have infections that are due to a specific bacteria (Vancomycin-Resistant Enterococcus)
- Trial name
- NCT00035854
- Testing
- Zyvox® / Linezolid
- Where
- 21 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pfizer
Enterobacterial Infection
Impact of Beta-lactams on the Microbiota and Relative Fecal Abundance of Mulltidrug Resistant Bacteria
The global spread of ESBL-producing enterobacteria (EBLSE) poses a real public health problem. The exposure of patients to antibiotic therapy leads to an increase in resistant bacterial populations within the digestive flora.
- Trial name
- NCT03338738
- Testing
- Stool culture ans swab
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Sepsis, Bloodstream Infections
Blood DdPCR for Early Identification and Dynamic Surveillance of Pathogenic Bacteria in ICU Septic Patients: a Single-centre, Prospective, Observational Study
The purpose of this study is to investigate the efficacy of droplet digital PCR (ddPCR) in identifying pathogenic organisms in ICU sepsis patients, aiming to find a method that allows early identification of pathogenic organisms…
- Conditions
- Sepsis, Bloodstream Infections, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT06791889
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Infection, Bacterial
Impact of Cefotaxime and Ceftriaxone on the Emergence and Carrying of Multidrug-Resistant Bacteria
Among enterobacteria, the production of ESBL is the first cause of multidrug resistance. The first cases of ESBL-producing enterobacteriaceae (EBLSE) infections were described during the 1980s and subsequently experienced global…
- Trial name
- CROCTX (NCT03903783)
- Testing
- Cefotaxime, Ceftriaxone
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Healthy Volunteer
Evaluation of Bacteria in the Mouth and Throat of Healthy Adults Before and After the Administration of Either Levofloxacin or Azithromycin, Both Antibiotic Medications
Evaluation of bacteria in the mouth and throat before study drug ( Levofloxacin, floroquinolone antibiotic and Azithromycin, a macrolide antibiotic) is started and then periodically for 6 weeks after the last dose of study drug…
- Trial name
- NCT00821782
- Testing
- Levofloxacin; Azithromycin
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Antibiotic Resistant Strain
Autologous Fecal Microbiota Transplantation to Prevent Antibiotic Resistant Bacteria Colonization
This study, a Randomized controlled trial of Autologous microbiome reconstitution to prevent Colonization by antibiotic rEsistant bacteria (RACE), seeks to investigate the safety, feasibility and the role of autologous fecal…
- Trial name
- RACE (NCT03061097)
- Testing
- Autologous fecal microbiota transplant (Auto-FMP Enema)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Research Institute
Bacteria Infection Mechanism
Study of Factors Influencing the Dynamics of Colonisation and Decolonisation of the Digestive Tract by Clostridioides Difficile in Infants
Clostridioides difficile (formerly C. difficile) is a bacterium found in the form of spores (a resistant form) to which patients may be exposed in a hospital environment.
- Trial name
- BBDIFF (NCT07512908)
- Testing
- cohort follow up
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Acute Respiratory Tract Infections
Effects of Nasal-spraying LiveSpo Navax in Treatment of Acute Respiratory Infections in Children
Rationals: Infection with the Respiratory Syncytial Virus (RSV) is one of the most common causes of respiratory tract diseases. However, treatment for pediatric RSV infection remains supportive to prevent co-infection bacteria…
- Trial name
- NCT05164692
- Testing
- LiveSpo Navax, 0.9% NaCl physiological saline
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- National Children's Hospital, Vietnam
Sepsis, Hemodynamic Instability
Therapeutic Drug Monitoring in Patients With Difficult-to-Treat Gram-Negative Bacterial Infections
A prospective, open-label, randomized controlled trial will be conducted to evaluate a novel TDM-guided therapy in management of DT-GNB infections.
- Conditions
- Sepsis, Hemodynamic Instability, Bacterial Infections, Therapeutic Drug Monitoring
- Trial name
- TDM-RCT (NCT05942157)
- Testing
- Therapeutic Drug Monitoring (TDM)
- Where
- Singapore
- Volunteers
- 810 people
- Sponsor
- Singapore General Hospital
Body Weight, Body Fat
Effect of Vigiis 101 Lactic Acid Bacteria Powder on Body Weight and Body Fat in Overweight Participants
This study is a randomized, double-blind, placebo-controlled, parallel-controlled trial (14 weeks in total), divided into three periods (screening, treatment, and discontinuation follow-up)
- Conditions
- Body Weight, Body Fat, Overweight
- Trial name
- NCT05869799
- Testing
- Vigiis 101 Lactobacillus Capsules
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SunWay Biotech Co., LTD.
Immunocompromised Host, Critical Care
ICU-acquired Colonization and Infection Related to MDR in Immunocompromised Patients
the number of immunocompromised patients hospitalized in the intensive care units (ICU) is increasing. They are at higher risk of colonization and/or infection with multi-resistant bacteria (MDR).
- Trial name
- CIMDREA (NCT04043793)
- Where
- 7 sites in France
- Volunteers
- 759 people
- Sponsor
- University Hospital, Lille