Clinical trials: Bacterial Overgrowth
Antimicrobial Stewardship, Drug Resistance, Bacterial
Optimising Community Antibiotic Use and Infection Control With Behavioural Interventions in Burkina Faso and DR Congo
Emergence of antibiotic resistance (AMR) is a serious concern for Low and Middle Income Countries (LMICs). Unregulated use of antibiotics, a major AMR driver, is highly prevalent in LMICs, with medicine stores as key providers.
- Trial name
- CABU-B/C (NCT05378880)
- Testing
- Behavioural intervention bundle to optimise antibiotic use and reduce the risk of human-to-human or environmental-animal-human transmission
- Where
- 2 sites in Burkina Faso, Democratic Republic of the Congo
- Volunteers
- 5,532 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Mortality, Resistance Bacterial
Azithromycin for Child Survival in Niger: Mortality and Resistance Trial
The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include…
- Conditions
- Mortality, Resistance Bacterial, Child, Only
- Trial name
- AVENIR (NCT04224987)
- Testing
- Azithromycin
- Where
- Niger
- Volunteers
- 864,493 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Small Intestinal Bacterial Overgrowth, Gastrointestinal Disorder, Functional
Therapeutic Effect of Olive Leaf Tea on SIBO
The goal of this study is to learn about the effect of olive leaf tea (OLT) in patients with small intestinal bacterial overgrowth aging from 18 to 60 years old.
- Trial name
- SIBO (NCT05915767)
- Testing
- Olive leaf tea
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Small Intestine Bacterial Overgrowth
Nutrition, Overgrowth, and Vaccine Efficacy in Low-income Settings
The purpose of this study is to assess the impact of small intestine bacterial overgrowth (SIBO) on childhood nutritional status, growth, and oral vaccine efficacy.
- Trial name
- NOVEL (NCT02745327)
- Where
- Bangladesh
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chronic Rhinosinusitis, Rhinosinusitis
Xylitol for Chronic Sinusitis
The purpose of this investigation is to conduct a randomized controlled trial within a subgroup of difficult-to-treat patients with CRS, evaluating the use of topical xylitol treatment concurrently with topical…
- Conditions
- Chronic Rhinosinusitis, Rhinosinusitis, Sinusitis, Drain Sinus
- Trial name
- NCT03229551
- Testing
- Xylitol, Saline
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Resistance Bacterial, Increased Drug Resistance
Decreasing Irrational Antimicrobial Use in Bangladesh: A Digital Intervention Program
We developed 'SmartAMR', a digital pharmacy system featuring real-time records, symptom checks, telemedicine, counselling, and medication reminders.
- Conditions
- Resistance Bacterial, Increased Drug Resistance, Drug Resistance, Microbial
- Trial name
- SmartAMR (NCT06313619)
- Testing
- SmartAMR
- Where
- Bangladesh
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Bacterial Resistance
Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island
In its report dated april 2014, World Health Organization confirms antibiotic resistance dissemination in all parts of the world, in hospitals and in community and worries about a possible comeback to a pre-antibiotic era during…
- Trial name
- AB-RUN (NCT03226314)
- Testing
- stool sample
- Where
- Reunion
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Peri-implant Mucositis, Oral Bacterial Infection
Bacterial Microbiota Characterization on Implant-supported PEEK and Titanium Provisional Abutments
The aim of this study is to determine the relative abundances of the different bacterial phyla and families in the microbiota present on the surface of PEEK implant-supported provisional abutments compared to titanium…
- Conditions
- Peri-implant Mucositis, Oral Bacterial Infection, Bacterial Resistance
- Trial name
- NCT03998865
- Testing
- Provisional abutment material
- Where
- Chile
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Michael Wendler Ernst
Tuberculosis, Resistance Bacterial
TB-CAPT MTB/XDR Study
The Cepheid Xpert MTB/XDR cartridge, which runs on the same platform as Xpert MTB/RIF Ultra, has been developed to detect additional resistance to isoniazid, fluoroquinolones and second-line injectable anti-tuberculosis drugs and…
- Conditions
- Tuberculosis, Resistance Bacterial, Diagnoses Disease
- Trial name
- NCT04567368
- Testing
- Xpert MTB/XDR
- Where
- 2 sites in South Africa
- Volunteers
- 753 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Bacterial Overgrowth
Clinical Evaluation of the Residual Antimicrobial Activity
The purpose of this study is to evaluate the residual antimicrobial efficacy of one test product as defined by the difference between the number of a challenge bacterial species recovered following exposure to the test product…
- Trial name
- NCT04495920
- Testing
- CGB-S-100
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CAGE Bio Inc.
Healthy Volunteers
Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota
The purpose of this study is to compare and contrast the effects of the probiotic Saccharomyces boulardii, the antibiotic amoxicillin/clavulanate and the combination on the gut microbiota of healthy volunteers.
- Trial name
- NCT01473368
- Testing
- Saccharomyces boulardii, Amoxicillin Clavulanate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Small Intestinal Bacterial Overgrowth, Gastrointestinal Disease
Efficacy of AEMCOLO (Rifamycin SV MMX) in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)
Open label interventional randomized pilot study utilizing two dosing regimens of AEMCOLO. The goal of this study is to evaluate effectiveness of a novel antibiotic, AEMCOLO (Rifamycin SV MMX) in the treatment of Small intestinal…
- Conditions
- Small Intestinal Bacterial Overgrowth, Gastrointestinal Disease, Gastrointestinal Infection
- Trial name
- NCT04501380
- Testing
- AEMCOLO (Rifamycin SV MMX)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bradley Connor
Small Intestinal Bacterial Overgrowth, Elderly
Characteristic of Intestinal Flora in Male Elderly With Small Intestinal Bacterial Overgrowth
We will focus on the intestinal flora structure, risk factors and clinical features of male elderly with SIBO in our study.
- Conditions
- Small Intestinal Bacterial Overgrowth, Elderly, Male, 16s rRNA
- Trial name
- IFOSIBO (NCT03659175)
- Testing
- SIBO
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Emergence of Bacterial Resistance to Antibiotics
Impact of the Choice of 3rd Generation Cephalosporins on the Emergence of Resistance in the Microbiota Intestinal.
CEREMI is an open, randomised prospective study in parallel groups in healthy volunteers. This study compare the effect of a monotherapy by ceftriaxone or cefotaxime on the emergence of resistance of enterobacteria to…
- Trial name
- CEREMI (NCT02659033)
- Testing
- ceftriaxone, Cefotaxime
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis
STI Prophylaxis and Emergence of Antimicrobial Resistance
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted…
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis, Antibiotic Resistance, Bacterial, Microbiome
- Trial name
- SPEAR (NCT06778083)
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University College, London
Gulf War Syndrome
Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex
The adverse impact of Gulf War Syndrome (GWS) on the health of veterans and on the resources of the VA Healthcare System underscores the need to resolve its underlying cause.
- Trial name
- NCT00956150
- Testing
- Lactulose Breath Test, Rifaximin
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Henry C. Lin, MD
Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Urine Metabolites in the Diagnosis of Disease
The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases.
- Conditions
- Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Crohn Disease, Celiac Disease
- Trial name
- NCT06710067
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Luventix, Inc.
Liver Disease
The Effect of Probiotics on Non Alcoholic Fatty Liver Disease
Nonalcoholic Fatty Liver Disease (NAFLD) has been suggested to be the most common cause of chronic liver disease in the general population in the Western World.
- Trial name
- NCT00808990
- Testing
- BioFemale
- Where
- Israel
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Evaluations, Diagnostic Self, Antimicrobial
ZnO Nanoparticles Coated Orthodontic Molar Tube
Orthodontic treatment is an elective procedure to improve the patient's dentofacial appearance. The complex design of fixed appliances provides a platform that leads to increased plaque accumulation around orthodontic brackets.
- Conditions
- Evaluations, Diagnostic Self, Antimicrobial, Orthodontic Appliance Complication, Bacterial Overgrowth
- Trial name
- ZnONPs (NCT06089720)
- Testing
- Zinc oxide nanoparticle coated orthodontic molar tubes (experimental), orthodontic molar tubes (control)
- Where
- Iraq
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Resistance Bacterial, Morality
Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)
The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include…
- Conditions
- Resistance Bacterial, Morality, Child Health, Implementation
- Trial name
- AVENIR (NCT05288023)
- Testing
- Azithromycin for Oral Suspension
- Where
- United States
- Volunteers
- 169,707 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco