Clinical trials: Bacterium; Agent
Bacteria Infection, Piperacillin, Tazobactam Drug Combination
Subcutaneous Piperacillin/Tazobactam Compared With Intravenous Treatment
The goal of this clinical trial is to learn whether subcutaneous piperacillin/tazobactam can provide drug exposure similar to standard intravenous piperacillin/tazobactam in adults who need treatment for an infection.
- Trial name
- STUPITA01 (NCT07481539)
- Testing
- Piperacillin, Tazobactam Drug Combination
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Sanitaria Universitaria Friuli Centrale
Pneumonia
Safety, Tolerability and Pharmacokinetics of Aerosolized Amikacin in Intubated and Mechanically-ventilated Patients With Nosocomial Pneumonia
This study is to understand how the inhaled form of amikacin is spread throughout the human body and how it is eliminated from the body and to make sure that giving an inhaled form of Amikacin to patients is safe and well…
- Trial name
- NCT01021436
- Testing
- Amikacin inhalation solution (BAY41-6551)
- Where
- 6 sites in United States, France
- Volunteers
- 30 people
- Sponsor
- Bayer
Pneumonia
M-ROSE Combined With mNGS in Severe Hospital-acquired Pneumonia
The purpose of this study is to determine the value of M-ROSE（microbiological rapid on-site evaluation）in severe hospital-acquired pneumonia.
- Trial name
- NCT05300776
- Testing
- M-ROSE analysis
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Chinese PLA General Hospital
Infection Control
Enhanced Room Cleaning in Intensive Care Units to Reduce Gown and Glove Contamination With Multi-drug-resistant Bacteria
The purpose of this study is to determine whether extra cleaning of frequently-contaminated surfaces in intensive care rooms is effective in preventing contamination of disposable isolation gowns and gloves with multi-drug…
- Trial name
- NCT01481935
- Testing
- Enhanced cleaning of surfaces in ICU rooms
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Maryland, Baltimore
Bacterial Infections
New Antibiotic to Treat Pediatric Patients With Infections Due to a Specific Bacteria (Vancomycin-Resistant Enterococcus)
This study will treat pediatric patients who have infections that are due to a specific bacteria (Vancomycin-Resistant Enterococcus)
- Trial name
- NCT00035854
- Testing
- Zyvox® / Linezolid
- Where
- 21 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pfizer
Bacterial Pneumonia
Comparative Study of Ceftaroline vs. Ceftriaxone in Adult Subjects With Community-Acquired Pneumonia
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of Community-Acquired Pneumonia
- Trial name
- CAP (NCT00621504)
- Testing
- Ceftaroline fosamil for Injection, IV Ceftriaxone, Clarithromycin
- Where
- 168 sites in United States, Argentina and 21 more
- Volunteers
- 606 people
- Sponsor
- Forest Laboratories
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Oral Bacteria Levels in the Mouth
Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
The primary objective was to evaluate the antibacterial effects of two toothpastes containing 0.3% triclosan, 2% copolymer and 0.234% sodium fluoride in a silica base as compared to a control regular fluoride toothpaste on…
- Trial name
- NCT02194621
- Testing
- Total Flavor option 1, Total Flavor option 2
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gram-Negative Bacterial Infections
Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenem
The purpose of this study is to determine whether the addition of meropenem to colistin is better than colistin alone in the treatment of clinically significant infections caused by multi-drug resistant bacteria
- Trial name
- NCT01732250
- Testing
- Colistin, Meropenem
- Where
- 7 sites in Greece, Israel and 1 more
- Volunteers
- 406 people
- Sponsor
- Mical Paul
Orthodontic Appliance Complication, Oral Mucositis
L Brevis for Traumatic Oral Lesions in Orthodontic Patients
Introduction: Traumatic oral lesions are common in the beginning of the orthodontic treatment, and pathogenic oral bacteria might be involved.
- Conditions
- Orthodontic Appliance Complication, Oral Mucositis, Bacterium; Agent
- Trial name
- NCT04398511
- Testing
- L brevis
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade de Passo Fundo
Wound Heal, Wound Healing Disturbance of
Evaluating Safety and Biological Effect on Wound Healing of ILP100-Topical in Subjects With Diabetic Foot Ulcers
A randomized, double-blind, placebo-controlled, parallel, exploratory phase 2a study to evaluate safety and biologic efficacy on wound healing of ILP100-Topical in subjects with diabetic foot ulcers during 26 weeks with a 5-year…
- Conditions
- Wound Heal, Wound Healing Disturbance of, Wound Healing Disorder, Wound Healing Delayed
- Trial name
- NCT05608187
- Testing
- ILP100-Topical (emilimogene sigulactibac) 5x10^7 CFU/cm^2, ILP100-Topical (emilimogene sigulactibac) 1x10^9 CFU/cm^2
- Where
- 2 sites in Sweden
- Volunteers
- 1 people
- Sponsor
- Ilya Pharma
Immunocompromised Host, Critical Care
ICU-acquired Colonization and Infection Related to MDR in Immunocompromised Patients
the number of immunocompromised patients hospitalized in the intensive care units (ICU) is increasing. They are at higher risk of colonization and/or infection with multi-resistant bacteria (MDR).
- Trial name
- CIMDREA (NCT04043793)
- Where
- 7 sites in France
- Volunteers
- 759 people
- Sponsor
- University Hospital, Lille
Bacterial Vaginosis, Vulvovaginal Candidiasis
Efficacy, Safety, and Dose-response of a Live Biotherapeutic Product in Women With Acute Vaginal Infection
The purpose of this clinical trial is to investigate the clinical efficacy and safety of a Live Biotherapeutic Product (BGY-1601-VT) intended as a first line of treatment in cases of acute vaginal infection without upfront…
- Trial name
- ELINA (NCT06450990)
- Testing
- BGY-1601-VT
- Volunteers
- 165 people
- Sponsor
- NEXBIOME THERAPEUTICS
Multi Drug Resistant Organisms, Antibiotic Resistance
Characterization of the Synergistic Antibacterial Effect of Verapamil on Bacterial Isolates From Cancer Patients
Multidrug-resistant (MDR) bacteria represent a significant global health challenge, particularly among immunocompromised populations such as cancer patients undergoing chemotherapy.
- Trial name
- NCT07505446
- Testing
- verapamil
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pregnancy Complications
Study of Drug Concentration of Ondansetron and Cefazolin in Mothers and Neonates
This study proposes to look at the pharmacokinetics of two drugs (Cefazolin and ondansetron) given routinely to pregnant women who are planning to deliver via cesarean section.
- Trial name
- NCT01357369
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Drug Resistance, Bacterial, Antimicrobial Drug Resistance
Comparison of Three Interventions for Antibiotic-Resistant Bacteria (ARB) Decolonization From the Gastrointestinal Tract
The aim of this research experiment is to evaluate the effectiveness of fecal microbiota transplantation (FMT) preceded by antibiotic pre-treatment versus probiotic therapy and a standard-of-care equivalent diet designed to…
- Trial name
- STOP-ARB3 (NCT07094984)
- Testing
- Fecal microbiota transplantation (FMT), Probiotic Therapy, Gut Microbiota Boosting Diet
- Where
- Poland
- Volunteers
- 360 people
- Sponsor
- Medical University of Warsaw
Sepsis, Hemodynamic Instability
Therapeutic Drug Monitoring in Patients With Difficult-to-Treat Gram-Negative Bacterial Infections
A prospective, open-label, randomized controlled trial will be conducted to evaluate a novel TDM-guided therapy in management of DT-GNB infections.
- Conditions
- Sepsis, Hemodynamic Instability, Bacterial Infections, Therapeutic Drug Monitoring
- Trial name
- TDM-RCT (NCT05942157)
- Testing
- Therapeutic Drug Monitoring (TDM)
- Where
- Singapore
- Volunteers
- 810 people
- Sponsor
- Singapore General Hospital
Bacterial Resistance, Infection Resistant to Multiple Drugs
SATURN 04 Nosocomial Acquisition Study
The study is the WP4 of the EU-funded (7th FW) project SATURN (Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria). A total of 6 surgical and 6 medical wards will participate in the study.
- Conditions
- Bacterial Resistance, Infection Resistant to Multiple Drugs, Staph Aureus Methicillin Resistant Colonization, Infection Due to ESBL Bacteria
- Trial name
- SATURN (NCT01208519)
- Where
- 3 sites in Italy, Romania and 1 more
- Volunteers
- 16,680 people
- Sponsor
- Catholic University of the Sacred Heart
Cross Infection, Carbapenem Resistant Bacterial Infection
Epidemiological Features of Emergent Highly Resistant Bacteria in Tunisian Intensive Care Units
Investigate the epidemiology, risk factors and impact on clinical practice of healthcare-associated infections with emergent highly drug-resistant (eHDR) pathogens, particularly carbapenem resistant enterobacteriaceae and…
- Conditions
- Cross Infection, Carbapenem Resistant Bacterial Infection, Vancomycin-Resistant Enterococcal Infection, Critical Illness
- Trial name
- NOSOREA3 (NCT06392568)
- Testing
- epidemiological records
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- Abderrahmane Mami Hospital
Oropharynx Abnormality, Pneumonia, Ventilator-Associated
Microbial and Pharmacological Assessment of Chlorhexidine
Ventilator-associated pneumonia (VAP) is the most frequent life-threatening nosocomial infection in the ICU. Oropharyngeal colonization with bacterial pathogens is the first step toward lung infection.
- Conditions
- Oropharynx Abnormality, Pneumonia, Ventilator-Associated, Chlorhexidine, Bacterium; Agent
- Trial name
- NCT03290105
- Volunteers
- 30 people
- Sponsor
- Hôpital Louis Mourier