Clinical trials: Bacterium; Agent
E. Coli Infection, Multi-antibiotic Resistance
Perinatal Transmission of MDR Bacteria
The investigators aim to conduct a prospective surveillance study of mothers and their infants born vaginally or by scheduled C-section and who are admitted to Northwestern Medicine Prentice Women's Hospital to determine the…
- Trial name
- ACQUIRE (NCT06148480)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pneumonia
A Study to Determine the Correct Dose of Amikacin Which is Delivered Directly to the Lungs of Ventilated Patients as an Aerosol Via an Investigational Device Called the Pulmonary Delivery Device System (PDDS)
This study is part of a research program too see if amikacin delivered as an aerosol directly to the lungs in combination with IV antibiotic therapy can help intubated patients with gram-negative pneumonia get better faster than…
- Trial name
- NCT01004445
- Testing
- Amikacin (BAY41-6551)
- Where
- 20 sites in United States, France and 1 more
- Volunteers
- 69 people
- Sponsor
- Bayer
Pneumonia
Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia
Through a prospective randomized controlled trial, we systematically evaluate the effects of Yiqi Huoxue Jiedu Formula combined with bacteriophage therapy on the bacterial clearance rate, disease improvement rate and mortality…
- Trial name
- NCT07612605
- Testing
- YHDF Drug, Bacteriophage
- Where
- 4 sites in China
- Volunteers
- 250 people
- Sponsor
- Chinese PLA General Hospital
Drug Resistance, Bacterial, Antimicrobial Drug Resistance
Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol
The aim of the study is to assess the safety and efficacy of new protocol fecal microbiota transplantation (FMT) in the eradication of antibiotic resistant bacteria, including those featuring of resistance to new generation…
- Trial name
- STOP-ARB2 (NCT06156956)
- Testing
- Fecal Microbiota Transplantation
- Where
- 5 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Human Biome S.A.
Resistance Bacterial
Decolonization of Gram-negative Multi-resistant Organisms (MDRO) with Donor Microbiota (FMT)
Colonization by Multiple Drug Resistant Organisms (MDROs) during patient hospitalization requires expensive isolation measures and renders the return or transfer to other departments or institutions often impossible.
- Trial name
- DEKODON (NCT04188743)
- Testing
- Allogenic FMT, Autologous FMT
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Gram-Negative Bacterial Infections
Feasibility Studies to Inform Novel Proposals to Avert Community-Based Antimicrobial Resistance Spread
There are many bacteria that naturally live in our gut and are essential for good health. These bacteria have a variety of helpful functions, such as aiding digestion, synthesizing vitamins, repressing the growth of harmful…
- Trial name
- NCT02666274
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
HIV-1-infection, Pneumocystis Pneumonia
Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria
Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis pneumonia and other infections in HIV positive patients with low immunity.
- Conditions
- HIV-1-infection, Pneumocystis Pneumonia, Opportunistic Infections, Preventive Therapy
- Trial name
- CoTrimResist (NCT03087890)
- Testing
- Cotrimoxazole
- Where
- 6 sites in Tanzania
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Bacterium; Agent
Colonization and Persistence of Bifidobacterium Longum
Healthy adults referred to as the absence of intestinal disorders, liver and kidney problems, lactose intolerance, and no use of ongoing medication for chronic diseases will be recruited.
- Trial name
- NCT01650753
- Testing
- Probiotic Powder
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Colonization, Multi Drug Resistant Bacteria
Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards
Emergence of bacterial resistance to antibiotics, which is a major public health issue, appears to involve predominantly commensal flora.
- Conditions
- Colonization, Multi Drug Resistant Bacteria, Hospitalized Patients
- Trial name
- NCT00520715
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Association Pour le Recherche en Infectiologie et en Médecine Interne
Non-Tuberculous Mycobacterial Pneumonia
Prolonged-Use of Inhaled Gaseous Nitric Oxide (gNO) for Adult With Non-Tuberculous Mycobacteria Infection
An open labeled Study (NCT03331445) is demonstrating encouraging safety and efficacy results for most subjects receiving 160ppm nitric oxide gas (gNO) for treatment of non-tuberculous mycobacteria (NTM) over a 15 day treatment…
- Trial name
- NCT03473314
- Testing
- Nitric Oxide gas at 160ppm
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Blood Disorders
Stool Transplantation to Reduce Antibiotic Resistance Transmission
During this prospective observational study, the investigators collect the information about the outcomes of fecal microbiota transplantation in patients with blood disorders, performed to eradicate gut colonization with…
- Trial name
- START (NCT02461199)
- Testing
- Fecal microbiota transplantation
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Intestinal Infections, Dysbacteriosis
INVESTIGATION of the EFFICACY and SAFETY of the DRUG "AS-PROBIONORM"
The subject of this clinical trial is the medicine "AS-Probionorm". Pharmacological group - Antidiarrheal drugs. Antidiarrheal microorganisms. Microorganisms that produce lactic acid.
- Trial name
- NCT06886399
- Testing
- "AS-Probionorm"
- Where
- Kazakhstan
- Volunteers
- 210 people
- Sponsor
- Industrial Microbiology LLP
A03 - Digestive System, B03 - Bacteria
Fermented Dairy Product and Bifidobacterium Diversity
Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains…
- Trial name
- NCT07700381
- Testing
- 28-days consumption of Product A in 45 to 60-year-old healthy subjects, 28-days consumption of Control product in 45 to 60-year-old healthy subjects
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Enterobacteriaceae Infections, Multi-antibiotic Resistance
FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae
Rates of antimicrobial resistance are increasing worldwide. There is increasing evidence that physiological gut microbiota is a large reservoir of antibiotic-resistance genes.
- Trial name
- FMT-CRE (NCT04759001)
- Testing
- Donor FMT
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
MDR Bacteria
Comparing Efficacy and Safety of (Meropenem + Colistin) Versus (Imipenem/Cilastatin + Tigecycline) on Eradication of Multi-Drug Resistance Bacteria
This study aims to compare the efficacy and safety of two antibiotic combinations (Colistin + Meropenem) vs (Imipenem/cilastatin+ Tigecycline) in the treatment of adults with MDR gram-negative infections.
- Trial name
- NCT07524920
- Testing
- "Imipenem/cilastatin" and "Tigecycline", "colistin" and "meropenem"
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Serious Bacterial Infection
Efficacy, Safety, and Tolerability of ATM-AVI in the Treatment of Serious Infection Due to MBL-producing Gram-negative Bacteria
Phase 3 study to determine the efficacy, safety, and tolerability of aztreonam- avibactam (ATM- AVI) versus best available therapy (BAT) in the treatment of hospitalized adults with complicated intra-abdominal infections (cIAI)…
- Trial name
- NCT03580044
- Testing
- ATM-AVI, BAT
- Where
- 42 sites in United States, Argentina and 10 more
- Volunteers
- 15 people
- Sponsor
- Pfizer
Patients With Multi Drug Resistant Gram-negative Bacteria, Colistin Resistance in Bacteria
Phenotypic and Genotypic Detection of Colistin Resistance
Evaluation of the disk elution test as reliable routine method for detection of colistin resistant among multidrug resistant gram-negative bacteria compared with broth microdilution.
- Trial name
- NCT07487116
- Testing
- disk elution test
- Volunteers
- 90 people
- Sponsor
- Assiut University
Multidrug-resistant Gram-negative Bacteria Infection
Clinical Usefulness of Therapeutic Drug Monitoring of Colistin in Patients Treated With Colistin.
Clinical usefulness of therapeutic drug monitoring of colistin in patients treated with colistin
- Trial name
- NCT03007290
- Testing
- Therapeutic drug monitoring
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
Gastrointestinal Microbiome, Immunoglobulin A
The Effect of Maternal Dadiah Supplementation During Pregnancy on Child Growth and Gastrointestinal Health Outcomes
The aim of our study is to assess the effect of giving dadiah as a supplement to pregnant women on improving the growth and digestive health of children.
- Conditions
- Gastrointestinal Microbiome, Immunoglobulin A, Growth; Stunting, Nutritional
- Trial name
- NCT05140928
- Testing
- Dadiah Pudding, Pudding without Dadiah
- Where
- Indonesia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Andalas University
Hospital Infection
Efficacy of Polymyxin B Against Infections Caused by Extensively Drug-resistant (XDR) Gram-Negative Bacteria
The objective of the study is to evaluate the efficacy of Polymyxin B for treatment Gram negative bacterial infection. The hypothesis of study is Polymyxin B would be the new antibacterial agents for Thai Gram negative infected…
- Trial name
- XDR (NCT02328183)
- Testing
- Polymyxin B
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University