Clinical trials: Baroreflex
Binge Drinking
Alcohol and Neural Cardiovascular Control in Binge Drinkers
This study evaluates the impact of evening alcohol consumption on sympathetic activity and baroreflex function in binge drinkers.
- Trial name
- NCT03567434
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Baylor University
Autonomic Nervous System, Baroreflex
Stress and the Nervous System
Models of stress such as hypoglycemia have identified that stress results the next day in decreased baroreflex sensitivity. This project will test the hypothesis that these delayed changes in autonomic nervous system function are…
- Conditions
- Autonomic Nervous System, Baroreflex, Stress, Physiological
- Trial name
- NCT02339506
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Congestive Heart Failure
Baroreflex Activation Therapy in Left Ventricular Assist Device Patients Study
This study will involve LVAD patients who have already received a clinically-indicated BAT (BAROSTIM) device. After recovery from LVAD implant, we will investigate the effects of BAT in a double-blind cross-over study design.
- Trial name
- BAT-VAD (NCT06195046)
- Testing
- Baroreflex Activation Therapy (BAT)
- Sponsor
- Medical University of South Carolina
Hypoxia, Diabetes Mellitus, Type 1
Studies on the Adaptive Responses to Hypoxia
The general aim of this study is to define the response to hypoxic challenge in patients with diabetes. The investigation will provide response for different questions that are central for explaining the development of…
- Trial name
- HYKRAND (NCT02629406)
- Testing
- Hypoxia
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Arteriosclerosis Obliterans
Preoperative Heart Rate Variability and Baroreflex Sensitivity in ASO Patients During Various Sleep Stages
The goal of this study is to evaluate the possible preoperative predictive value of altered heart rate variability (HRV) and baroreflex sensitivity in different sleep stages for postoperative adverse cardiac events (i.e.
- Trial name
- Barosleep (NCT00712946)
- Where
- Finland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Carotid Artery Plaque, Diagnosis
Preoperative Identification of the Histologically "Vulnerable" Plaque Using Non-invasive Imaging, Biomechanical Assessment and Baroreflex Evaluation in Patients With Severe Carotid Stenosis
Carotid artery stenosis due to atherosclerotic plaques accounts for an important cause of ischemic stroke. Current research seeks to risk stratify asymptomatic patients by characterizing rupture-prone plaques.
- Trial name
- PREDICT (NCT05566080)
- Testing
- Carotid endarterectomy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Sleep Apnea Syndrome
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.
- Trial name
- NCT00746928
- Testing
- Chronic Intermittent Hypoxia
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Pain, Postoperative, Atrial Fibrillation
BRS and Outcomes in Cardiothoracic Surgery
The purpose of this study is to determine whether baroreceptor sensitivity (the ability of your body to change your heart rate and/or blood pressure in response to a situation) has any effect on how likely you are to suffer…
- Conditions
- Pain, Postoperative, Atrial Fibrillation, Cognitive Dysfunction
- Trial name
- NCT03243279
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University
Cystic Fibrosis, Endothelial Dysfunction
Vascular Health and Function in Cystic Fibrosis
The goal of this observational study is to learn whether blood vessel health and function differ between adults aged 40 years or older with cystic fibrosis (CF) who are taking CFTR modulator therapy and healthy adults of the same…
- Conditions
- Cystic Fibrosis, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- CF-VHF (NCT07904325)
- Testing
- Non-invasive vascular, cerebrovascular and autonomic assessment
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Hypotension, Cesarean Section
"Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section"
Spinal anesthesia-induced hypotension is one of the most frequent and clinically significant complications of obstetric anesthesia, occurring in up to 50-80% of parturients undergoing elective cesarean section.
- Conditions
- Hypotension, Cesarean Section, Hemodynamic Instability, Anxiety, Anticipatory
- Trial name
- BREATHE-CS (NCT07494955)
- Testing
- Mindfulness-Based Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aysenur Dostbil
HFrEF - Heart Failure With Reduced Ejection Fraction
Impact of Barostimulation on Hemodynamics in Adults With Heart Failure
This study evaluates the effects of the implantation and adjustment of the CVRx Barostim device in adult patients with heart failure with reduced ejection fraction who are receiving maximally tolerated doses of guideline directed…
- Trial name
- BREATHE-HF (NCT07335510)
- Testing
- Baroreflex Activation Therapy
- Where
- 7 sites in United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
Cerebrovascular Accident, Baroreflexes
Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke
After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general.
- Conditions
- Cerebrovascular Accident, Baroreflexes, Autonomic Nervous System Diseases
- Trial name
- NCT00422474
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Prehypertension, Blood Pressure
HIRREM for Pre-Hypertension
This randomized, controlled clinical pilot trial will evaluate the effects associated with in-office use of closed-loop, acoustic stimulation neurotechnology (High-resolution, relational, resonance-based, electroencephalic…
- Conditions
- Prehypertension, Blood Pressure, Autonomic Nervous System Imbalance, Cardiovascular Risk Factor
- Trial name
- NCT03332043
- Testing
- HIRREM, Ambient Nature Sounds
- Sponsor
- Wake Forest University Health Sciences
Smoking
Endothelial Function and Autonomic Regulation After Short-term Smoking Cessation: Varenicline Versus Placebo
The purpose of this study is to evaluate endothelial function and autonomic regulation (for example, heart rate and blood pressure) in smokers before and after short-term smoking cessation.
- Trial name
- NCT00673595
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Insufficiency;Cardiac, Cancer
Effect of Physical Training in Patients With Heart Failure Caused by Chemotherapy for Cancer Treatment
New therapies for cancer increased patient survival, but led to the recognition of adverse effects associated with cancer treatment, such as the use of chemotherapy.
- Conditions
- Insufficiency;Cardiac, Cancer, Cardiotoxicity, Heart Failure
- Trial name
- NCT04047901
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure
Influences of Angiotensin-neprilysin Inhibition on Sympathetic Activity in Heart Failure
The autonomic nervous system plays an important role in controlling the circulation. Increased sympathetic activity has detrimental effects in patients with heart failure.
- Trial name
- ARNI-Sy (NCT03415906)
- Testing
- sacubitril+valsartan, valsartan
- Where
- Germany
- Sponsor
- Hannover Medical School
Hypertension
Rheos Feasibility Trial
The Rheos Feasibility Trial is designed to assess safety, device performance, and protocol parameters of the CVRx Rheos Baroreflex Therapy in patients with severe hypertension that are refractory to full drug therapy.
- Trial name
- NCT01077180
- Testing
- Implantation of the Rheos System, Standard of care medical management
- Volunteers
- 16 people
- Sponsor
- CVRx, Inc.
Breast Adenocarcinoma
Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study
Breast cancer is the most common cancer worldwide, with over 2.2 million new cases diagnosed in 2020. Treatments such as chemotherapy often lead to a reduced exercise capacity, mainly due to cardiovascular and neuromuscular…
- Trial name
- PROTECT-08B (NCT07069790)
- Testing
- Test of neuromuscular fatigue and associated hemodynamic responses
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre Paul Strauss
Breast Cancer, Lymphoma
The Effects of Anthracycline-based Chemotherapy on Peripheral Vascular Function
The overall goal of this project is to determine the effects of anti-cancer chemotherapy on reflex control of blood pressure and vascular function.
- Conditions
- Breast Cancer, Lymphoma, Chemotherapy Effect
- Trial name
- NCT03062878
- Testing
- Arterial blood pressure, Vascular Ultrasound, Venous blood sample
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carl Ade, M.S., Ph.D.
Hypoglycemia
Hypoglycemia and Autonomic Nervous System Function
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Trial name
- HypoANS (NCT01816893)
- Testing
- Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital