Clinical trials: Barretts Esophagus With High Grade Dysplasia
Barrett's Esophagus
Polar Wand Carbon Dioxide Cryotherapy for Barrett's Esophagus
The purpose of this pilot study is to provide an initial assessment of the feasibility, safety and efficacy of Polar Wand carbon dioxide cryotherapy for treatment of Barrett's low grade and high grade dysplasia by use in a small…
- Trial name
- NCT01477177
- Testing
- Polar Wand carbon dioxide cryotherapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Dysplasia
Wide Area Transepithelial Sample Esophageal Biopsy Combined With Computer Assisted 3-Dimensional Tissue Analysis (WATS3D) For the Detection of High Grade Esophageal Dysplasia and Adenocarcinoma
This is a multi-center, prospective, randomized study which will enroll patients undergoing endoscopic surveillance due to a history of histologically confirmed dysplasia.
- Conditions
- Barrett Esophagus, Esophageal Dysplasia, Esophageal Adenocarcinoma
- Trial name
- NCT03015389
- Testing
- Diagnostic Test
- Where
- Belgium
- Volunteers
- 170 people
- Sponsor
- CDx Diagnostics
Barretts Esophagus, Esophageal Cancer
Cryotherapy for Barrett's Esophagus and Early Esophageal Cancers
This is a single center study to evaluate the efficacy and safety of a new ablation technique involving the spray of liquid nitrogen through a catheter (cryotherapy) via an upper endoscopy (EGD) to ablate Barrett's esophagus with…
- Trial name
- NCT00650988
- Testing
- Cryospray Ablation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Cancer, Precancerous Condition
Erlotinib in Treating Patients With Barrett Esophagus
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. Erlotinib may keep esophageal cancer from forming in patients with Barrett esophagus by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00566800
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis, biopsy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kansas City Veteran Affairs Medical Center
Barrett's Esophagus, CIS
Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity For PDT Treatment Of High Grade Dysplasia,CIS or Early Adenocarcinoma In Barrett's Esophagus
Patient's with High Grade Dysplasia, Carcinoma in situ or Early Adenocarcinoma in Barrett's Esophagus are injected with HPPH and one day later are endoscopically treated with light from a laser.
- Conditions
- Barrett's Esophagus, CIS, HGD
- Trial name
- NCT01238042
- Testing
- HPPH
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Esophageal Cancer
The Effects of Sorafenib on Molecular Barrett's Esophagus Cancer
To determine whether sorafenib is able to change pre-cancerous cells in a way that we believe is important in the progression of cancer.
- Trial name
- Barrett's (NCT00619242)
- Testing
- sorafenib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Chicago
Barrett Esophagus, Esophageal Stenosis
Barretts oEsophageal Resection With Steroid Therapy Trial
Barretts mucosa is a premalignant condition of the oesophagus, which can progress to cancer. Oesophageal cancer is aggressive, with a 5 year survival of only ~15%.
- Trial name
- BERST (NCT02004782)
- Testing
- Prednisolone
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Barretts Esophagus
Long Term Barrett's Endoscopic Mucosal Resection Study
Analysis of long term outcomes of patients undergoing endoscopic mucosal resection for Barrett's oesophagus with high grade dysplasia and/or early intramucosal carcinoma (IMC).
- Trial name
- CBE (NCT02200250)
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Barretts Esophagus With High Grade Dysplasia
Calcium Electroporation in Patients With Cell Changes in the Esophagus
The aim of this first-in-man study is to evaluate the safety of calcium electroporation used in patients with Barrett's esophagus high-grade dysplasia through an endoscopic system.
- Trial name
- NCT04605419
- Testing
- Calcium electroporation
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Michael Patrick Achiam
Barrett's Esophagus
Comparison of Treatments for Barrett's Esophagus With High-Grade Dysplasia/Early Adenocarcinoma
Prospective randomized study comparing radiofrequency ablation and cryotherapy for the endoscopic treatment of Barrett's esophagus. The study is powered to assess clinical equivalence (non-inferior) of the treatment regimens.
- Trial name
- NCT01961778
- Testing
- Radio-Frequency Ablation, Cryotherapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus
Safety of Photodynamic Therapy (PDT) in the Ablation of High-grade Dysplasia (HGD) in Barrett's Esophagus (BE)
Photodynamic therapy (PDT) uses a combination of a drug, porfimer sodium, and a light from a non heated laser. The activation of the drug is done by lighting of abnormal areas using a fiber optic device.
- Trial name
- Oedisse (NCT01209013)
- Testing
- Medlight PDT Balloon, Endoscopy, Endoscopy with biopsy
- Sponsor
- Pinnacle Biologics Inc.
Barrett Esophagus, Dysplasia
Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease
This pilot clinical trial studies how well a swallowable sponge cell sampling device and next generation sequencing work in detecting esophageal cancer in patients with low or high grade dysplasia, Barrett esophagus, or…
- Conditions
- Barrett Esophagus, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02890979
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- OHSU Knight Cancer Institute
Barrett's Esophagus Without Dysplasia, Barrett's Esophagus With Dysplasia
Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)
This is a prospective randomized clinical trial examining how IRIS (Intelligent Real-time Image Segmentation) affects biopsy patterns in VLE (Volumetric laser endomicroscopy).
- Conditions
- Barrett's Esophagus Without Dysplasia, Barrett's Esophagus With Dysplasia, Barrett's Esophagus With Low Grade Dysplasia, Barrett's Esophagus With High Grade Dysplasia
- Trial name
- NCT03814824
- Testing
- IRIS (Intelligent real-time image segmentation), VLE (Volumetric laser endomicroscopy)
- Where
- 3 sites in United States
- Volunteers
- 148 people
- Sponsor
- Northwell Health
Barrett Esophagus, Esophageal Adenocarcinoma
Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Esophageal Adenocarcinoma
This study explores the use of a minimally invasive screening tool (a sponge on a string device) to detect Barrett's esophagus and esophageal adenocarcinoma and to develop a laboratory test for the detection of Barrett's…
- Trial name
- NCT07212491
- Testing
- Non-Interventional Study
- Where
- 5 sites in United States
- Volunteers
- 450 people
- Sponsor
- Mayo Clinic
Dysphagia, Dysplasia
Esophageal Cytology With FISH in Detecting Esophageal Cancer
This clinical trial studies whether esophageal cytology plus fluorescence in situ hybridization (FISH) is equal to or better than esophago-gastro-duodenoscopy (EGD) or upper endoscopy for the early detection of esophageal cancer.
- Conditions
- Dysphagia, Dysplasia, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02100189
- Testing
- Cytology Specimen Collection Procedure, Esophagogastroduodenoscopy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Barretts Esophagus With High Grade Dysplasia, Barrett Adenocarcinoma
Endoscopic Mucosal Resection and Cellular Matrix
This study is being done to test the usefulness of extracellular matrix (ECM) a thin sheet placed over the site after endoscopic mucosal resection to promote healing of the esophagus.
- Trial name
- NCT03240679
- Testing
- Acell MatriStem® Surgical Matrix
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Barrett's Esophagus With High Grade Dsyplasia, Early Esophageal Cancer
Probe-based Volumetric Laser Endomicroscopy (pVLE) of Endoscopic Mucosal Resection (EMR) Tissue in Patients With Barrett's Dysplasia
This study is to assess the diagnostic accuracy and precision of the Probe-based Volumetric Laser Endomicroscopy (pVLE) imaging system in detecting dysplasia in BE in both in vivo and ex vivo imaging of Endoscopic Mucosal…
- Trial name
- VLE EMR (NCT02366039)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Mayo Clinic
Esophageal Cancer, Precancerous Condition
Photodynamic Therapy in Treating Patients With Precancerous Esophageal Conditions or Early Stage Esophageal Cancer
RATIONALE: Photodynamic therapy uses a drug, such as HPPH, that is absorbed by tumor cells. The drug becomes active when it is exposed to light, and kills tumor cells.
- Trial name
- NCT00281736
- Testing
- HPPH
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Roswell Park Cancer Institute
Barretts Esophagus, High Grade Dysplasia
Endoscopic Tri-Modal Imaging in Patients With Barrett's Esophagus
This study is being done to determine if a new endoscope will help doctors identify pre-cancer or early cancer lesions in patients who have Barrett's esophagus.
- Conditions
- Barretts Esophagus, High Grade Dysplasia, Early Esophageal Adenocarcinoma
- Trial name
- ETMI (NCT00586989)
- Testing
- Upper endoscopy with biopsy
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Esophagus Cancer, Esophageal Cancer Stage
A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for the early detection of esophageal adenocarcinoma and its precursor lesions, using advanced machine learning and state-of-the-art…
- Conditions
- Esophagus Cancer, Esophageal Cancer Stage, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- EMERALD (NCT06381583)
- Testing
- EMERALD (Esophageal MicroRNAs for BaRRett's esophagus, Adenocarcinoma, and Dysplasia)
- Where
- United States
- Volunteers
- 658 people
- Sponsor
- City of Hope Medical Center