Clinical trials: Basal Cell Carcinoma (BCC)
Head and Neck Cancer, Lung Cancer
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00021333
- Testing
- filgrastim, cisplatin, paclitaxel
- Where
- 18 sites in United States
- Volunteers
- 29 people
- Sponsor
- Fox Chase Cancer Center
Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
This phase II trial tests the combination of nivolumab and ipilimumab with sirolimus and prednisone for the treatment of skin (cutaneous) cancer that cannot be removed by surgery (unresectable) or that has spread from where it…
- Conditions
- Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
- Trial name
- NCT05896839
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 26 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Keratinocyte Carcinoma, Basal Cell Carcinomas
Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment
The investigators seek to evaluate the effectiveness of fractional laser therapy and tirbanibulin ointment to treat squamous and basal cell carcinomas.
- Conditions
- Keratinocyte Carcinoma, Basal Cell Carcinomas, Squamous Cell Carcinoma, Skin Cancer
- Trial name
- NCT07010692
- Testing
- Tirbanibulin ointment 1%, non-ablative fractional laser
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Bruce Robinson, MD
Basal Cell Carcinoma, Optical Coherence Tomography
Optical-Coherence Tomography for the Non-invasive Diagnosis and Subtyping of Basal Cell Carcinoma
Rationale: To date, the diagnosis and subtyping of basal cell carcinoma (BCC) is verified with histopathology which requires a biopsy.
- Conditions
- Basal Cell Carcinoma, Optical Coherence Tomography, Deep Learning, Artificial Intelligence
- Trial name
- OCT-BCC (NCT05041777)
- Testing
- Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 963 people
- Sponsor
- Maastricht University Medical Center
Skin Cancer, Basal Cell Carcinoma
Raman Spectroscopy and Skin Cancer
The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors.
- Conditions
- Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- NCT06384924
- Testing
- Raman Spectroscopy handheld probe (EmVision, FL, USA), Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tiezhi Zhang
Basal Cell Carcinoma, Elderly
RCT Treatment Versus Non Treatment of Low-risk BCCs in Elderly
This study will be a randomized controlled trial (RCT). Patients with a minimum age of 75 years who consult at the dermatology department of the Ghent University Hospital and who are diagnosed with minimum one lesion suspicious…
- Trial name
- BASINEL (NCT05110924)
- Testing
- Standard of care, Monitoring
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- University Hospital, Ghent
Basal Cell Carcinoma
Study of an Artificial Human Skin Medicine for Patients With Basal Cell Carcinoma Undergoing Reconstructive Surgery
Phase II Clinical Trial Evaluating the Safety and Efficacy of a Tissue Engineered Autologous Skin Substitute Reconstructive Surgery for Basal Cell Carcinoma
- Trial name
- NCT05234658
- Testing
- PHITAH, PHIT, Skin Autograft
- Where
- 4 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Andalusian Network for Design and Translation of Advanced Therapies
Head and Neck Cancer, Infection
Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer
RATIONALE: Giving fluconazole may be effective in preventing or controlling mucositis caused by radiation therapy to the head and neck.
- Conditions
- Head and Neck Cancer, Infection, Oral Complications
- Trial name
- NCT00002533
- Testing
- fluconazole, radiation therapy
- Where
- United States
- Sponsor
- University of Miami
Skin Basal Cell Carcinoma
Effectiveness of Narrow Margins in Patients With Low-Risk Basal Cell Carcinoma Undergoing Surgery
This clinical trial studies the effectiveness of narrow margins in patients with low-risk basal cell carcinoma undergoing surgery to remove skin lesions on the face.
- Trial name
- NCT02579551
- Testing
- Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
BCC, BCC - Basal Cell Carcinoma
Use of Jet-injection in Photodynamic Therapy for Basal Cell Carcinoma
The purpose of this study is to find out whether injecting ALA into the skin with a jet-injection device and activating the drug with light is a safe treatment that causes few or mild side effects in people with basal cell…
- Conditions
- BCC, BCC - Basal Cell Carcinoma, Basal Cell Carcinoma, Basal Cell Cancer
- Trial name
- NCT04552990
- Testing
- Jet injection of ALA, Surgical excision, Illumination
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Basal Cell Carcinoma
An Observational Study to Determine the Clinical Cure Rate of Therapeutic up Front Shave Removal of Basal Cell Carcinoma of the Skin With Long Term Follow up to Evaluate Recurrence
Determine the effectiveness of a deep shave removal as a definitive treatment for basal cell carcinoma (BCC) without the need for a follow up surgical procedure.
- Trial name
- NCT02296970
- Testing
- Deep shave removal using a blue surgical blade
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Basal Cell Carcinoma
Calcium Electroporation for Basal Cell Carcinomas - Proof of Concept Study
25 patients with primary low-risk basal cell carcinoma treated with calcium electroporation
- Trial name
- NCT05046262
- Testing
- Calcium chloride
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Bispebjerg Hospital
Carcinoma, Basal Cell
Study of Electronic Brachytherapy for Cutaneous Basal Cell Carcinoma
Electronic brachytherapy (EBT) offers an isotope-free radiation therapy modality for the treatment of specific skin lesions, especially non-melanoma skin cancers (NMSC).
- Trial name
- NCT02939027
- Testing
- Electronic Brachytherapy (6,1 Gy), Electronic Brachytherapy (7 Gy)
- Volunteers
- 40 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Basal Cell Carcinoma in Basal Cell Nevus Syndrome
Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS)
The study will assess the safety and efficacy of SUBA-Cap in subjects with Basal Cell Carcinoma Nevus Syndrome.
- Trial name
- NCT02354261
- Testing
- SUBA-Itraconazole
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- HedgePath Pharmaceuticals, Inc.
Autoimmunity, Melanoma
How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
The purpose of this research study is to examine the relationship between the microbiota (microscopic organisms) in the gut and the activity of the immune system during skin cancer immunotherapy.
- Conditions
- Autoimmunity, Melanoma, Merkel Cell Carcinoma, Squamous Cell Carcinoma of the Skin
- Trial name
- MINING (NCT03370861)
- Testing
- Immunotherapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Washington University School of Medicine
Locally Advanced Basal Cell Carcinoma
L19IL2 or L19TNF or L19IL2/TNF in Patients With Basal Cell Carcinoma (BCC)
Open label, randomized study in patients with LaBCC not eligible or refusing surgery or radiation therapy according to the evaluation of a local interdisciplinary tumor board.
- Trial name
- NCT07227350
- Testing
- L19IL2, L19TNF, L19IL2/L19TNF
- Where
- 18 sites in United States, Germany and 3 more
- Volunteers
- 180 people
- Sponsor
- Philogen S.p.A.
Superficial Basal Cell Carcinoma
To Determine the Maximum Tolerated Dose Level (MTD) of PEP005 Topical Gel in Patients With sBCC
The purpose of this study is to determine maximum tolerated dose level (MTD) of PEP005 Topical Gel for the treatment of superficial basal cell carcinoma on the trunk
- Trial name
- NCT00432185
- Testing
- PEP005
- Where
- 9 sites in United States
- Volunteers
- 117 people
- Sponsor
- Peplin
Skin Cancer, Mucosal Neoplasm of Oral Cavity
Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT)
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for superficial cutaneous, mucosal or soft tissue neoplasia
- Conditions
- Skin Cancer, Mucosal Neoplasm of Oral Cavity, Soft Tissue Neoplasm
- Trial name
- NCT03737734
- Testing
- Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Alpha Tau Medical LTD.
Carcinoma
Study Evaluating the Efficacy and Safety of 0.05% Ingenol Mebutate (Picato® 500) in the Treatment of Basal Cell Carcinoma
Basal cell carcinomas (BCCs) are the most common form of cancer. The treatment of BCC can be surgical or topical for the low-risk subtypes. Topical treatments used for BCC are imiquimod and photodynamic therapy (PDT).
- Trial name
- PICABAS (NCT03546166)
- Testing
- Picato 0.05% Topical Gel
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Melanoma, Squamous Cell Carcinoma of the Head and Neck
Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC)
The purpose of this study is to test the safety of a course of injections containing Poly-ICLC in patients with advanced solid tumors that can be easily and safely reached with a needle.
- Conditions
- Melanoma, Squamous Cell Carcinoma of the Head and Neck, Squamous Cell Carcinoma of the Skin, Sarcoma of the Skin
- Trial name
- Hiltonol (NCT01984892)
- Testing
- Poly-ICLC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Nina Bhardwaj