Clinical trials: Basilar Artery Occlusion
Acute Ischemic Stroke, Basilar Artery Occlusion
Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
The aim of this study is to assess the efficacy and safety of endovascular treatment versus medical management in patients with acute basilar artery occlusion with extended time window of 24-72 hours from onset.
- Trial name
- ANGEL-BAO (NCT06101667)
- Testing
- Best medical management, Endovascular treatment
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Basilar Artery Occlusion
Endovascular Therapy for Acute Basilar Artery Occlusion With Large Ischemic Core
Acute basilar artery occlusion is associated with high mortality and severe disability. Previous randomized trials have demonstrated the benefit of endovascular therapy in selected patients with basilar artery occlusion; however…
- Conditions
- Acute Ischemic Stroke, Basilar Artery Occlusion, Large Ischemic Core
- Trial name
- NCT07672795
- Testing
- Endovascular Therapy, Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Mild Ischemic Stroke, Basilar Artery Occlusion
Rescue Endovascular Treatment After Neurological Deterioration in Initially Mild Basilar Artery Occlusion in an Extended Time Window
A prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial to evaluate whether best medical management (BMM) combined with endovascular therapy (EVT) improves neurological outcomes compared to BMM alone…
- Conditions
- Acute Mild Ischemic Stroke, Basilar Artery Occlusion, Rescue Endovascular Treatment, Extended Time Window
- Trial name
- RESCUE-BAO (NCT06843356)
- Testing
- Endovascular Treatment
- Where
- 2 sites in China
- Volunteers
- 159 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Basilar Artery Occlusion, Large Ischemic Core
EVT in Acute Basilar Artery Occlusion With Large Infarction Core
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial designed to evaluate the efficacy and safety of best medical management (BMM) combined with endovascular treatment (EVT) versus BMM alone in…
- Conditions
- Basilar Artery Occlusion, Large Ischemic Core, Large Core Infarct, Endovascular Treatments
- Trial name
- BOLT (NCT07090941)
- Testing
- Endovascular Treatment
- Where
- 2 sites in China
- Volunteers
- 372 people
- Sponsor
- The First Affiliated Hospital of Hainan Medical University
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion
To assess the effect of endovascular thrombectomy alone compared to intravenous thrombolysis plus endovascular thrombectomy in acute basilar artery occlusion patients within 4.5 hours from onset on efficacy and safety outcomes.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05827042
- Testing
- Intravenous thrombolysis, Endovascular thrombectomy
- Where
- China
- Volunteers
- 338 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE-LC (NCT07345702)
- Testing
- Endovascular Therapy
- Where
- China
- Volunteers
- 518 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Artery Occlusion
Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke
Patients presenting to the emergency department with an acute ischemic stroke due to basilar artery occlusion within 24 hours of stroke onset will be assessed to determine their eligibility for randomization into the trial.
- Trial name
- POST-ETERNAL (NCT05105633)
- Testing
- Tenecteplase, Standard Care (which may include intravenous Alteplase)
- Where
- 17 sites in Australia, Brazil and 1 more
- Volunteers
- 688 people
- Sponsor
- University of Melbourne
Acute Ischemic Stroke, Basilar Artery Occlusion
Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours
This study is designed to investigate the efficacy and safety of intravenous tenecteplase before interhospital transfer from a non-endovascular capable center(nECC) to an endovascular capable center (ECC) for thrombectomy in…
- Trial name
- OPTION-2 (NCT07203625)
- Testing
- Tenecteplase thrombolysis
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
To assess the effect of intravenous tenecteplase plus endovascular thrombectomy (EVT) compared to EVT alone on 4.5 to 24 hours after stroke due to basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05701956
- Testing
- Tenecteplase, Endovascular thrombectomy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion
The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion
This study assesses the efficacy and safety of endovascular treatment for acute mild basilar artery occlusion within a multicenter, prospective, open-label, endpoint-blinded, randomized controlled clinical trial.
- Conditions
- Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion, Endovascular Treatment
- Trial name
- NCT07390032
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Feng Gao
Acute Basilar Artery Occlusion, Endovascular Therapy
The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction
This study assesses the efficacy and safety of endovascular therapy in patients with acute basilar artery occlusion with large core infarction within a multicenter, prospective, open-label, blinded endpoint, randomized controlled…
- Conditions
- Acute Basilar Artery Occlusion, Endovascular Therapy, Large Core Infarction
- Trial name
- NCT07333950
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Basilar Artery Occlusion
Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive Stroke
Currently, both intravenous thrombolysis (IVT) followed by endovascular treatment (EVT) and EVT alone are widely used for the treatment of acute ischemic stroke (AIS) caused by basilar artery occlusion (BAO) (AIS-BAO), but no…
- Conditions
- Acute Ischemic Stroke, Basilar Artery Occlusion, Thrombosis, Alteplase
- Trial name
- BEST-BAO (NCT05631847)
- Testing
- Endovascular treatment, Intravenous thrombolysis (Alteplase)
- Where
- 96 sites in China
- Volunteers
- 345 people
- Sponsor
- Sichuan Academy of Medical Sciences
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Ischemic Stroke, Acute, Minocycline
Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)
This is a multi-center, evaluator-blinded, randomized, open-label, proof of concept trial to explore possible beneficial effect of adjunctive oral minocycline on acute ischemic stroke (AIS) undergoing endovascular treatment due…
- Conditions
- Ischemic Stroke, Acute, Minocycline, Endovascular Treatment, Basilar Artery Occlusion
- Trial name
- MIST-B (NCT05512910)
- Testing
- Minocycline
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Basilar Artery Occlusion, Endovascular Treatment
A Comparison of Contact Aspiration Versus Stent Retriever for Acute Basilar Artery Occlusion
Compare the effectiveness and safety of contact aspiration (CA) and stent retriever (SR) in acute ischemic stroke patients with basilar artery occlusion.
- Trial name
- ANGEL-COAST (NCT05615038)
- Testing
- Contact aspiration Thrombectomy, Stent retriever thrombectomy
- Where
- 6 sites in China
- Volunteers
- 338 people
- Sponsor
- Beijing Tiantan Hospital
Acute Basilar Artery Occlusion, Posterior Circulation Large Infarct
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with…
- Trial name
- NCT06924996
- Testing
- Endovascular Thrombectomy (EVT)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Feng Gao
Acute Ischemic Stroke, Basilar Artery Occlusion
Basilar Artery Occlusion Chinese Endovascular Trial in the Extended Time Window
A prospective, multi-center, randomized, controlled, open-label, blinded-endpoint trial to evaluate the safety and efficacy of endovascular mechanical thrombectomy for acute basilar artery occlusion in the extended time window
- Trial name
- BAOCHE2 (NCT06560203)
- Testing
- Mechanical thrombectomy
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Capital Medical University
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial
Endovascular treatment of acute ischemic stroke has shown strong benefit in several prospective randomized trials in the anterior circulation and endovascular therapy for basilar artery occlusion has shown promising results in…
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Cerebrovascular Disorders
- Trial name
- NCT02737189
- Testing
- Mechanical embolectomy, Medical Treatment
- Where
- 36 sites in China
- Volunteers
- 217 people
- Sponsor
- Xuanwu Hospital, Beijing
Basilar Artery Occlusion, Posterior Circulation Brain Infarction
Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion
The standard therapy for acute ischemic posterior circulation stroke (PCS) often leads to poor functional outcomes and high mortality rates, despite all advances in reperfusion therapy.
- Trial name
- NCT06489925
- Testing
- Cerebrolysin
- Volunteers
- 20 people
- Sponsor
- University Hospital Sestre Milosrdnice
Posterior Circulation Acute Ischemic Stroke Due to Large Vessel Occlusion of the Vertebral or Basilar Artery Needing Endovascular Thrombectomy
PRECISE (PERFUSION IMAGING TO IDENTIFY POSTERIOR CIRCULATION CANDIDATES FOR THROMBECTOMY)
We hypothesize that patients with a favorable Critical Area Perfusion Score (CAPS≤3) on cerebral perfusion imaging will have a favorable response to revascularization by thrombectomy and that patients with a CAPS>3 will not
- Trial name
- SWISS-PRECISE (NCT06375174)
- Testing
- Thrombectomy
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Carlo Cereda