Clinical trials: Bed Rest
Type 2 Diabetes, Muscular Atrophy
Exercise Training as an Intervention to Improve Muscle Function and Recovery Following Bed Rest in Older Adults With Type 2 Diabetes
The purpose of this research is to gather data on how exercise can help recovery of muscle mass, strength, and physical function after bedrest in older adults with pre-diabetes and type 2 diabetes.
- Conditions
- Type 2 Diabetes, Muscular Atrophy, Sedentary Behavior, Exercise
- Trial name
- RECOVER (NCT04057677)
- Testing
- Bed Rest Intervention, Exercise Program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Metabolic Responses to Inactivity
Bed Rest, Inactivity and Early Responses
To evaluate the early metabolic responses (whole body and within muscle tissue) to a single day of whole body physical inactivity (i.e. bed-rest), and evaluate the contribution of inactivity per se vs alterations in diet
- Trial name
- BIER (NCT02981927)
- Testing
- Physical inactivity
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Pregnancy, High Risk, Anxiety State
The Effects of Music on the Anxiety and Sleep Quality of Pregnant Women on Bed Rest for a High-risk Pregnancy
The purpose of this study is to identify the effects of music on the anxiety and sleep quality of women with high-risk pregnancy having bed rest in the hospital in Turkey.
- Conditions
- Pregnancy, High Risk, Anxiety State, Sleep Quality
- Trial name
- NCT05316415
- Testing
- Acemaşiran Music Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Healthy Aging, Physical Inactivity
Bed Rest Study SBI 2023
The study will consist of three groups of subjects. Ten young male subjects (18-30 years) will lie supine for 21 days, 10 older male subjects (65+ years) will lie supine for 10 days, and a third group of 10 older male subjects…
- Trial name
- NCT06141291
- Testing
- High protein diet, OGTT
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Motility Disorder, Catabolic State
Gastro-intestinal and Hormonal Responses to Systemic Inflammatory Disease
The aim of this study is to describe hormonal responses and changes of the gastrointestinal (GI) tract during healthy and catabolic inflammatory conditions.
- Conditions
- Motility Disorder, Catabolic State, Endotoxemia
- Trial name
- NCT04056286
- Testing
- Whey, 3-OHB/whey
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypoxia, Bone Resorption
Planetary Habitat Simulation: Bone Metabolism Studies
Bone losses are well known to occur in response to unloading (in microgravity or during immobilisation) and in patients with chronic obstructive airway disease (COPD).
- Trial name
- PlanHab (NCT02637921)
- Testing
- Hypoxia, Ambulatory, Normoxia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Preterm Birth, Activity Restriction
DE-RESTRICT: Deimplementing Activity Restriction for Preterm Birth Prevention
DE-RESTRICT is a pilot study testing whether a strategy to reduce the use of activity restriction and bedrest in pregnancy is acceptable, appropriate, and feasible for prenatal care providers, and whether it changes how often…
- Conditions
- Preterm Birth, Activity Restriction, Bed Rest, Low-Value Care
- Trial name
- NCT07698483
- Testing
- Multicomponent deimplementation strategy
- Where
- 2 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Simulated Microgravity by Head Down Tilt Bedrest, Weightlessness
A 60 Days Head Down Tilt Bedrest With Artificial Gravity and Cycling Exercise on 24 Healthy Male (BRACE)
The objective of this study is to investigate whether a cycling exercise coupled with artificial gravity via a short-arm human centrifuge helps to prevent and / or reduce the deleterious effects induced by 60 days of…
- Trial name
- BRACE (NCT06544213)
- Testing
- Control Group, Countermeasure Supine Bike, Countermeasure AG-Bike
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Weightlessness
Space Flight Simulation to Study Effects of Micro-gravity Through Bed Rest
Space flight simulation study to study effects of microgravity through bedrest coupled with flight exercise counter-measures.
- Trial name
- FAP (NCT00891449)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Muscle Protein Synthetic Response to Protein
Nutritional and Physical Intervention During Bed Rest
Hospitalization often involves long periods of bed rest and reduced nutritional intake, which can lead to skeletal muscle loss and anabolic resistance.
- Trial name
- Bed-Plant (NCT07280819)
- Testing
- Nutritionally complete tube feed providing a sole source of nutrition with a plant-dominant protein mix, Nutritionally complete tube feed providing a sole source of nutrition with an animal-based protein mix, Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis
The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
- Trial name
- 2d-BR (NCT03877822)
- Testing
- Habitual activity, Bed rest
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Exeter
Coronary Artery Disease With Myocardial Infarction
Clinical Trial to Assess the Safety of Reducing the Time of Bed Rest After Cardiac Catheterization
Reducing the rest time after diagnostic cardiac catheterization for three hours does not increase the complications concerning to the procedure, compared to the rest of five hours.
- Trial name
- Three-Cath (NCT01740856)
- Testing
- Rest three hours, Rest five hours
- Where
- Brazil
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiovascular Abnormalities, Weightlessness
Electroacupuncture is Effective in Cardiac Deconditioning Induced by Head-down Bed Rest
To investigate the changes of cardiovascular function during short-term simulated weightlessness after electroacupuncture (EA) treatment．
- Trial name
- NCT02300207
- Testing
- electronic acupuncture treatment instrument
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Cartilage Degeneration, Weightlessness
Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
- Trial name
- NCT06612372
- Testing
- 60-day-6° head-down bed rest
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Bed Rest, Space Analogue
Impact of Energy Density on Energy Intake During Bed Rest
Brief summary: This study is conducted in the context of a 60 days strict bed-rest study with 6° head-down-tilt (HDT) body position.
- Trial name
- ED-REST (NCT06571877)
- Testing
- Dietary intervention with manipulation of the energy density
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Healthy, Body Weight
IC-BASAROTs: New Practice Method for More Accurate Bed-side Assessment of Individual Energy Expenditure
Assessment of resting energy expenditure (REE) by indirect calorimetry (IC) in 1400 healthy individuals for arithmetical transformation into an bedside tool to estimate energy requirements in dietary practice (BASAROTs).
- Conditions
- Healthy, Body Weight, Overweight, Thinness
- Trial name
- NCT02682537
- Where
- 6 sites in Germany
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences Neubrandenburg
Healthy
Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity
Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.
- Trial name
- NCT00175968
- Testing
- bed rest, hypocaloric nutrition
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Healthy
Evaluation of an Oral Nutritional Supplement on Lean Body Mass in Healthy Older Subjects.
The study will evaluate the effects of oral nutritional supplements (ONS) on attenuating the lean body mass (LBM) loss that occurs after bed rest.
- Trial name
- NCT02090387
- Testing
- ONS without AN777, ONS containing AN777
- Where
- 3 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Type 2 Diabetes, Insulin Resistance
The Effects of Two Days of Bedrest on Insulin Resistance in Type 2 Diabetics
The hypothesis of this study is that bed rest in diabetic patients will result in a deterioration of metabolic control (primarily glucose). Specific aims: 1.
- Trial name
- NCT00508599
- Testing
- Study 2 (48 hours of complete bed rest)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Disuse Atrophy
Bed-rest, Muscle Mass and Insulin Sensitivity
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
- Trial name
- NCT02109380
- Testing
- Bed rest
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center