Clinical trials: Bedrest
Muscle Atrophy, Insulin Sensitivity
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Space flight is associated with detrimental changes to the human body, including bone and muscle loss, fluid changes and deconditioning of muscles in the heart and blood vessels.
- Trial name
- NCT03495128
- Testing
- Bed Rest, Reconditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Bone Metabolism, Electrolyte Metabolism
Salty Life 7 Study: Effect of High Salt Intake on Several Physiological Systems in Immobilisation
The Salty Life 7 study aimed to examine the effect of a high salt (sodium chloride, NaCl) intake on different forms of sodium retention, acid-base balance and bone metabolism and other influenced physiological systems.
- Conditions
- Bone Metabolism, Electrolyte Metabolism, Acid-Base Metabolism, Energy Metabolism
- Trial name
- SL7 (NCT01183299)
- Testing
- Dietary salt intake
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Bed Rest, Space Analogue
Impact of Energy Density on Energy Intake During Bed Rest
Brief summary: This study is conducted in the context of a 60 days strict bed-rest study with 6° head-down-tilt (HDT) body position.
- Trial name
- ED-REST (NCT06571877)
- Testing
- Dietary intervention with manipulation of the energy density
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Muscular Atrophy
Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants
This investigation aimed to compare the response of older adult and young men to 14 day bed-rest and subsequent 28 day rehabilitation.
- Trial name
- BEDREST (NCT02694471)
- Testing
- physical inactivity or bed rest with supervised recovery
- Where
- Slovenia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Cartilage Degeneration, Weightlessness
Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
- Trial name
- NCT06612372
- Testing
- 60-day-6° head-down bed rest
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Bedrest
Effect of Bedrest With and Without Exercise on the Heart
The purpose of this research sub-study is to determine the changes in heart function during the bedrest period using ultrasound and MRI. This topic is important for medical care of astronauts in space.
- Trial name
- NCT00598494
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Simulated Microgravity by Head Down Tilt Bedrest, Weightlessness
A 60 Days Head Down Tilt Bedrest With Artificial Gravity and Cycling Exercise on 24 Healthy Male (BRACE)
The objective of this study is to investigate whether a cycling exercise coupled with artificial gravity via a short-arm human centrifuge helps to prevent and / or reduce the deleterious effects induced by 60 days of…
- Trial name
- BRACE (NCT06544213)
- Testing
- Control Group, Countermeasure Supine Bike, Countermeasure AG-Bike
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Weightlessness Simulation
A Comparison Study Between 10 Days of Dry Immersion Versus 10 Days of Head-down Bedrest on 20 Healthy Male Volunteers
The space agencies are actively engaged in studying the physiological adaptation to space environment through studies on board the International Space Station (ISS) but also on the ground.
- Trial name
- VIVALDI 3 (NCT06777329)
- Testing
- 10 days of dry immersion, 10 days of Head Down Bed Rest
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Healthy Aging, Physical Inactivity
Bed Rest Study SBI 2023
The study will consist of three groups of subjects. Ten young male subjects (18-30 years) will lie supine for 21 days, 10 older male subjects (65+ years) will lie supine for 10 days, and a third group of 10 older male subjects…
- Trial name
- NCT06141291
- Testing
- High protein diet, OGTT
- Where
- Slovenia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Disuse Atrophy
Bed-rest, Muscle Mass and Insulin Sensitivity
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
- Trial name
- NCT02109380
- Testing
- Bed rest
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
In Vitro Fertilization
Bed Rest or no Bed Rest?
A comparative study to determine whether bed rest after embryo transfer (ET) affects on IVF (In Vitro Fertilization)outcome. This study includes 240 patients undergoing IVF treatment with donated oocytes.
- Trial name
- NCT01343992
- Testing
- Bed rest, No bedrest
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Microgravity, Caloric Restriction
BRAHMS: Bed Rest And HypoMetabolism Study
The goal of this single arm, interventional monocentric clinical trial is to investigate the physiological effects of a combination of head-down bedrest and caloric restriction on the human body.
- Trial name
- BRAHMS (NCT07499167)
- Testing
- head down bedrest and caloric restriction
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Aged
Evaluation of AN777 on Elderly Subjects During Bed Rest and Recovery
The primary objectives are to evaluate the effect of AN777 on muscle strength loss that occurs during bed rest, and to investigate whether AN777, in association with resistance training, will support muscle strength recovery…
- Trial name
- NCT00945581
- Testing
- Experimental Nutritional Powder Formula
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Hypoxia
Planetary Habitat Simulation: Nutrition Studies
A loss of body weight has been documented in lowland-living individuals when exposed to hypoxic environments, such as at high altitude, or under laboratory conditions.
- Trial name
- PlanHab (NCT02293772)
- Testing
- Hypoxic ambulatory, Hypoxic Bedrest, Normoxic Bedrest
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Protein Synthetic Response to Protein
Nutritional and Physical Intervention During Bed Rest
Hospitalization often involves long periods of bed rest and reduced nutritional intake, which can lead to skeletal muscle loss and anabolic resistance.
- Trial name
- Bed-Plant (NCT07280819)
- Testing
- Nutritionally complete tube feed providing a sole source of nutrition with a plant-dominant protein mix, Nutritionally complete tube feed providing a sole source of nutrition with an animal-based protein mix, Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Spinal Cord Injury
Mechanisms of Orthostatic Intolerance in Spinal Cord Injured Individuals and Following Bed Rest
The primary purpose of this study is to investigate the relationship between the extent of neurologic (nerve) impairment in patients with spinal cord injuries and how well the nerves passing down the spine to the heart and blood…
- Trial name
- NCT00175773
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Metabolic Responses to Inactivity
Bed Rest, Inactivity and Early Responses
To evaluate the early metabolic responses (whole body and within muscle tissue) to a single day of whole body physical inactivity (i.e. bed-rest), and evaluate the contribution of inactivity per se vs alterations in diet
- Trial name
- BIER (NCT02981927)
- Testing
- Physical inactivity
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy
Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity
Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.
- Trial name
- NCT00175968
- Testing
- bed rest, hypocaloric nutrition
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Bone Diseases, Metabolic, Acid-Base Imbalance
The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation
Mainly due to the absence of gravitational forces in weightlessness, astronauts suffer from an increased bone loss- negatively affecting health and vitality during a mission.
- Conditions
- Bone Diseases, Metabolic, Acid-Base Imbalance, Muscular Atrophy, Sprains and Strains
- Trial name
- NUC (NCT01509456)
- Testing
- Potassium Bicarbonate
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center