Clinical trials: Benign Tumor of Thyroid
Benign Tumor of Thyroid, Hyperparathyroidism
Bilateral Superficial Cervical Plexus Block in Thyroid/Parathyroid Surgery
To compare efficacy and safety between bilateral superficial cervical plexus block combined with intravenous sedation (RA group) and general anesthesia (GA group) for thyroid and parathyroid operations.
- Trial name
- NCT04051099
- Testing
- Bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 16 ml), Dexmedetomidine plus propofol infusion, Local infiltraion analgesia
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Cancer of the Thyroid, Neoplasms, Thyroid
Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm
This protocol will evaluate microRNA biomarkers in blood and fine-needle aspirate biopsies (FNAB) of thyroid nodules. MicroRNA profiles will be determined and evaluated for their utility in pre-operative diagnosis, in particular…
- Conditions
- Cancer of the Thyroid, Neoplasms, Thyroid, Thyroid Adenoma, Thyroid Cancer
- Trial name
- NCT01433809
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Norman Eberhardt
Dysphagia, Esophageal, Dysphagia, Oral Phase
Post-thyroidectomy Dysphagia: An International Multicentric CONSORT - Compatible RCT
The most common and feared complications of total thyroidectomy are vocal cord paralyses and hypocalcemia. However, post-thyroidectomy dysphagia is not uncommon and has important consequences on the quality of life (QoL).
- Conditions
- Dysphagia, Esophageal, Dysphagia, Oral Phase, Dysphagia Comes and Goes, Thyroiditis
- Trial name
- Dysphagia-TT (NCT04410601)
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Umraniye Education and Research Hospital
Thyroid Nodule, Thyroid Cancer
Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses
This proposal is designed as a pilot study for the use of laser ablation for local control of symptomatic (e.g compressive) benign thyroid masses in 20 patients.
- Conditions
- Thyroid Nodule, Thyroid Cancer, Thyroid Neoplasms, Nodular Goiter
- Trial name
- NCT00615537
- Testing
- Laser Ablation of Thyroid Nodule
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BioTex, Inc.
Thyroid Nodule, Thyroid Diseases
Fusion UltraSound Imaging Of the Thyroid GlaNd With I-124 PET. Evaluation of Nodule Allocation.
Regular thyroid diagnostics versus augmented thyroid work-up with additional I-124 PET/US fusion for metabolic-sonographic nodule allocation in patients with benign thyroid diseases
- Conditions
- Thyroid Nodule, Thyroid Diseases, Thyroid Goitre
- Trial name
- FUSION iENA (NCT03128255)
- Testing
- Assessment of already preacquired I-124 PET/US
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Jena University Hospital
Thyroid Nodule (Benign)
CellFX ® Percutaneous Electrode (PE) Treatment of Symptomatic Benign Thyroid Nodules
The objective of this clinical feasibility study is to evaluate initial clinical safety and device performance of the CellFX Percutaneous Electrode (PE) System for the treatment of symptomatic benign thyroid nodules.
- Trial name
- NCT06117085
- Testing
- CellFX® Percutaneous Electrode (PE) System
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Pulse Biosciences, Inc.
Thyroid Nodule (Diagnosis)
Ultrasound-guided Microwave Ablation of Benign Thyroid Nodules
The goal of this clinical trial is to learn if microwave ablation of benign thyroid nodules under local anaesthesia is a safe and effective procedure compared to open thyroidectomy.
- Trial name
- NCT07906821
- Testing
- ultrasound-guided percutaneous microwave ablation (MWA)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Thyroid Cancer, Papillary, Leptin Levels
Leptin Levels in Papillary Thyroid Cancer
The purpose of this study is to evaluate Leptin levels in females, in the setting of papillary thyroid cancer, benign thyroid nodules, and in normal females without thyroid disease.
- Trial name
- LL-PTC (NCT01659385)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Thyroid Nodule
Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules
This is a prospective trial to evaluate the effects of laser ablation on symptomatic benign thyroid nodules. The study is designed to assess the clinical efficacy, safety, tolerability and impact on symptoms of single ultrasound…
- Trial name
- NCT04277455
- Testing
- Laser ablation of benign thyroid nodule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johnson Thomas
Thyroid Nodule
Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules
Use of ethanol injection in treatment of cystic thyroid nodule
- Trial name
- NCT03257930
- Testing
- ethanol injection
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- hassan harby mohamed
Thyroid Nodule (Benign)
Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
To evaluate long-term outcomes of ultrasound-guided thermal ablation for benign thyroid nodules
- Trial name
- NCT06729762
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Cancer, Thyroid Cancer, Papillary
Circulating Biomarkers to Identify Thyroid Cancer
This study aimed to identify the potential circulating biomarkers of protein, mRNAs, and long non-coding RNAs (lncRNAs) to differentiate the papillary thyroid cancers from benign thyroid tumors.
- Conditions
- Thyroid Cancer, Thyroid Cancer, Papillary, Benign Thyroid Tumor
- Trial name
- NCT04594720
- Testing
- Identification group, Validation group
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Thyroid Cancer, Thyroid Nodule
The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer
118 adults with benign thyroid nodules who were seen at a UW Health clinic for a fine needle biopsy and do not need surgery will be enrolled and can expect to be on study for a one-time visit of up to 60 minutes.
- Conditions
- Thyroid Cancer, Thyroid Nodule, Benign Thyroid Nodule
- Trial name
- NCT05132478
- Testing
- Emotionally Supportive Video, Standard Video
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Wisconsin, Madison
Thyroid Nodules, Pulsed Field Ablation
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
- Trial name
- NCT07226804
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Diabetes Mellitus, Type 2, Thyroid Nodule (Benign)
Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules in Type 2 Diabetes
A 2-years prospective, randomized and multicentric study will be performed to assess the efficacy of metformin compared to sitagliptin on benign thyroid nodules size ≥ 2 cm, in newly diagnosed patients with type 2 diabetes.
- Trial name
- METNODTHYR (NCT04298684)
- Testing
- METFORMIN, Sitagliptin
- Where
- 4 sites in France, Guadeloupe and 1 more
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Thermal Ablation, Fine Needle Aspiration Biopsy
Ultrasound and Cytological Evaluation 3 Years After Radiofrequency Thermal Ablation of Benign Thyroid Nodules : a Prospective Exploratory Cohort of 180 Nodules
There is no scientific data on post-thermal ablation cytological aspects, but treated nodules that grow back significantly after a procedure justify a new cytology in order not to ignore a neoplastic process.
- Conditions
- Thermal Ablation, Fine Needle Aspiration Biopsy, Thyroid Nodules
- Trial name
- CYTOTHYRAF (NCT05726981)
- Testing
- Fine needle aspiration biopsy (FNAB)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroid Neoplasms, Thyroid Carcinoma
Influence of Thyroid Hormones on the Woundhealing Process
Main goal of this clinical investigation is to investigate different cytokines in wound fluids of euthyroid vs. hypothyroid patients. As a primary endpoint we want to evaluate if different cytokine levels in euthyroid vs.
- Trial name
- NCT00929318
- Testing
- blood sampling
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Hannover Medical School
Thyroid Nodule
Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules
The purpose of this study is to prospectively compare percutaneous radiofrequency ablation (RFA) versus percutaneous laser ablation (LA) for the treatment of solid thyroid nodules.
- Trial name
- LARA (NCT02714946)
- Testing
- Percutaneous Laser Ablation, Percutaneous Radiofrequency Ablation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Campus Bio-Medico University
Hypothyroidism, Hyperthyroidism/Thyrotoxicosis
Evaluation of Different Diagnostic Therapeutic Strategies in Patients with Thyroid Pathology
Observational single-center prospective and retrospective, nonpharmacological, spontaneous cohort study.
- Conditions
- Hypothyroidism, Hyperthyroidism/Thyrotoxicosis, Thyroid Nodule (Benign), Thyroid Carcinoma
- Trial name
- NCT06779747
- Where
- Italy
- Volunteers
- 5,850 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Thyroid Nodules
RFA of Benign Thyroid Nodules: Clinical Outcomes and Quality of Life Study
The purpose of this observational research is to evaluate and compare clinical outcomes after treatment for symptomatic benign multinodular goiter (MNG) patients.
- Trial name
- NCT05189314
- Testing
- Thyroidectomy, Radiofrequency Ablation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University