Clinical trials: Best Disease
Gastrointestinal Cancer, Metastatic
A Study to Find the Best Dose of BI 905711 in Combination With Chemotherapy and to Test Whether This Dose Helps People With Advanced Gastrointestinal Cancers
This study is open to adults with advanced colorectal cancer or with advanced pancreatic cancer. The study has 2 parts. In the first part, participants with colorectal cancer get a medicine called BI 905711 combined with…
- Trial name
- NCT05087992
- Testing
- BI 905711, FOLFIRI, Bevacizumab
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 13 people
- Sponsor
- Boehringer Ingelheim
Viral Hepatitis B
DEcentralize Testing, Education, and Linkage to Care by Using Electronic Best Practice Advisory for Hepatitis B (DETECT-B)
The overarching goal of this implementation study is to determine if an enhanced model of hepatitis B testing and linkage to care could be integrated into a public healthcare facility.
- Trial name
- DETECT-B (NCT06403657)
- Testing
- An enhanced model of hepatitis B testing and linkage to care
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vietnam Viral Hepatitis Alliance
COPD, Ventilator Lung
Best End-Expiratory and Driving-pressure for Individualized Flow Controlled Ventilation in Patients With COPD
Patients with chronic obstructive pulmonary disease (COPD) have a significantly increased risk of postoperative pulmonary complications (PPC).
- Conditions
- COPD, Ventilator Lung, Anesthesia
- Trial name
- NCT05812365
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Small Cell Lung Cancer
Study of Picoplatin Efficacy After Relapse
Picoplatin is a new type of platinum drug that has been investigated in several clinical trials, and may provide an improved safety profile over current treatment options.
- Trial name
- SPEAR (NCT00465491)
- Testing
- picoplatin, best supportive care
- Where
- 143 sites in Argentina, Belarus and 13 more
- Volunteers
- 399 people
- Sponsor
- Poniard Pharmaceuticals
Age-Related Macular Degeneration, Geographic Atrophy
Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD
The objective of this study is to determine the safety and effectiveness of the smaller incision, new generation (SING), implantable miniature telescope (IMT) in patients with moderate-severe central vision loss due to late-stage…
- Trial name
- CONCERTO (NCT05438732)
- Testing
- smaller incision, new generation implantable miniature telescope (SING-IMT)
- Where
- 10 sites in United States
- Volunteers
- 125 people
- Sponsor
- VisionCare, Inc.
Colorectal Neoplasms
Nintedanib (BIBF 1120) vs Placebo in Refractory Metastatic Colorectal Cancer (LUME-Colon 1)
The objective of this Phase III study is to evaluate the efficacy of nintedanib in patients with metastatic colorectal cancer (mCRC) after failure of previous treatment with standard chemotherapy and biological agents.
- Trial name
- NCT02149108
- Testing
- Nintedanib (BIBF 1120), BSC
- Where
- 129 sites in United States, Argentina and 23 more
- Volunteers
- 768 people
- Sponsor
- Boehringer Ingelheim
Hematologic Malignancies, Lymphoma
DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics
The purpose of this study is to evaluate whether a novel decision support tool called PRIME (Preference Reporting to Improve Management and Experience), which combines values-elicitation with tailored feedback to patients and…
- Conditions
- Hematologic Malignancies, Lymphoma, Multiple Myeloma, Leukemia
- Trial name
- DISCOVERY (NCT06296368)
- Testing
- Preference Reporting to Improve Management and Experience (PRIME)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Atrial Fibrillation, Persistent, Cognitive Function
Cognitive Function in Patients With Persisted Atrial Fibrillation
Compare the difference of cognitive function between different treatment strategy in patients with persistent atrial fibrillation
- Trial name
- SMART-AF (NCT04508491)
- Testing
- Rhythm control, Rate control
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Assessment of Patients With Suspected Coronary Artery Disease (CAD): What is the Best Initial Imaging Strategy?
Patients who present with chest pain are investigated with tests designed to confirm or exclude the presence of Coronary Artery Disease (CAD), as well as determine risk of poor outcome.
- Trial name
- IMAGE-CAD (NCT01668290)
- Where
- Canada
- Volunteers
- 173 people
- Sponsor
- Harald Becher
Asthma
STYLE - Symbicort Single Inhaler Therapy vs Conventional Therapy in Treatment of Persistent Asthma
The purpose of the study is to compare the efficacy of a flexible dose of Symbicort with conventional stepwise treatment according to asthma treatment guidelines in patients with persistent asthma
- Trial name
- NCT00252824
- Testing
- Budesonide/formoterol Turbuhaler vs Conventional Best Asthma Therapy
- Where
- 53 sites in Chile, Croatia and 8 more
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Arthroplasty, Replacement, Knee
MIKROBE Management of Infected Knee Replacements-Obtaining Best Evidence
Following a prosthetic knee joint infection, two types of operative approach can be undertaken to treat the infection: a one-stage or two-stage revision operation.
- Trial name
- MIKROBE (NCT04458961)
- Testing
- One-stage, Two-stage
- Where
- 2 sites in United Kingdom
- Volunteers
- 3 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Aorta Aneurysm
Type 1 Endoleak : Fenestrated Custom Made Endograft (FEVAR) Versus Open Surgery Explantation (OSR) : What's the Best
Proximal type 1A endoleak is a worrying complication after endovascular repair of an abdominal aortic aneurysm (EVAR). The ideal solution is not obvious between relining by FEVAR and endograft explantation.
- Trial name
- NCT06187051
- Testing
- FEVAR, Explantation
- Volunteers
- 200 people
- Sponsor
- University Paul Sabatier of Toulouse
Myofascial Pain Syndrome - Neck
Comparing Physical Therapy Interventions on Craniovertebral Angle (CVA) in Cervical Myofascial Pain Syndrome (MPS)
Myofascial pain syndrome (MPS) and radiculopathy are prevalent musculoskeletal conditions that afflict a substantial portion of the population, causing significant discomfort and impairments in daily functioning.
- Trial name
- NCT07098754
- Testing
- Dry Needling, Trigger point therapy, Maitlands' Mobilizations
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- National Orthopedic and General Hospital
Anorexia Nervosa
Family Therapy and Anorexia Nervosa : Which is the Best Approach?
The aim of this study is to evaluate whether the implementation of Multiple Family Therapy (MFT) within a multi-disciplinary treatment program for Anorexia Nervosa (AN) in adolescence is at least as effective in terms of clinical…
- Trial name
- THERAFAMBEST (NCT03350594)
- Testing
- Systemic Family Therapy, Multiple Family Therapy
- Where
- 5 sites in France
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Institut Mutualiste Montsouris
Osteosarcoma, Osteosarcoma in Children
Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With Osteosarcoma
The participants of this study will be children, adolescents, and young adults with residual osteosarcoma, which cannot be removed completely through surgery.
- Conditions
- Osteosarcoma, Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults
- Trial name
- CabOSTar (NCT06341712)
- Testing
- Cabozantinib, Best Supportive Care (BSC)
- Where
- 16 sites in United States, Belgium and 8 more
- Volunteers
- 10 people
- Sponsor
- Ipsen
Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Carcinoma
Bevacizumab, Sorafenib Tosylate, and Temsirolimus in Treating Patients With Metastatic Kidney Cancer
This randomized phase II trial studies different combinations of bevacizumab, temsirolimus, and sorafenib tosylate to see how well they work compared with bevacizumab alone in treating patients with kidney cancer that has spread…
- Conditions
- Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v7
- Trial name
- NCT00378703
- Testing
- Bevacizumab, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 559 sites in United States, Peru
- Volunteers
- 361 people
- Sponsor
- National Cancer Institute (NCI)
Mantle Cell Lymphoma (MCL)
Study to Assess Effect of Oral Venetoclax Tablet in Combination With Oral Ibrutinib Capsule on Best Overall Response of Complete Response in Adult Japanese Participants With Relapsed/Refractory Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a form of Non-Hodgkin Lymphoma (NHL - cancer of the lymphatic system in blood) where cells from outer edge of the lymph nodes, called mantle zone become cancerous.
- Trial name
- NCT04477486
- Testing
- Ibrutinib, Venetoclax
- Where
- 12 sites in Japan
- Volunteers
- 13 people
- Sponsor
- AbbVie
Sickle Cell Disease
Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy
Background: Sickle cell disease is a common inherited blood disorder. Kidney disease is a major cause of problems in people with sickle cell disease.
- Trial name
- NCT03958643
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Preeclampsia, Aspirin
Low Dose Aspirin Alerts in High-Risk Pregnancies
The goal of this study is to assess the effect of an electronic health record (EHR) clinical decision support tool, also known as a best practice alert (BPA), on healthcare provider recommendations for low dose aspirin use in a…
- Conditions
- Preeclampsia, Aspirin, Clinical Decision Support Systems, Economics, Behavioral
- Trial name
- NCT05802940
- Testing
- Electronic health record best practice alert
- Where
- United States
- Volunteers
- 830 people
- Sponsor
- Geisinger Clinic
Refractive Errors, Vision Disorders
Handheld Device Compared With a Standard Eye Care Diagnostic Device in Measuring Ophthalmic Refraction
This study is exploratory and examines whether the best-corrected visual acuities (BCVA's) from trial frames created with the refraction results obtained from a novel handheld optical device yields results similar to the…
- Trial name
- NCT04693247
- Testing
- EQ103
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- EyeQue Corp.