Clinical trials: Best Disease
Stroke, Amputation
Statistical Parametric Mapping (SPM 1D) for Stroke and Trans-tibial Amputation
Gait analysis is commonly performed in clinical practice. However, it is complex and requires an understanding of the activation of muscles in lower limbs, trunk, and upper limbs in a specific spatiotemporal pattern and the…
- Trial name
- NCT04169594
- Testing
- 3D Gait Analysis with Statistical Parametric Mapping
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Tan Tock Seng Hospital
Critical Limb Ischemia
BEST vCLI Registry
For subjects with critical limb ischemia, identify patient, physician/hospital, and geographic factors associated with variations in treatment strategies; compare treatments and outcomes, including quality of life, cost and cost…
- Trial name
- BEST (NCT04191746)
- Where
- United States
- Volunteers
- 1,009 people
- Sponsor
- Duke University
Postnatal Depression
Three Model Care Pathways for Postnatal Depression
The study evaluates three best-practice care pathways for postnatal depression (PND) by comparing sole General Practitioner (GP) management to GP management in combination with CBT-based counselling from either a Psychologist or…
- Trial name
- NCT01002027
- Testing
- CBT-Counselling
- Where
- Australia
- Volunteers
- 68 people
- Sponsor
- University of Melbourne
Urothelial Carcinoma
Maintenance With Niraparib In Patients With Advanced Urothelial Cancer After 1st-line Platinum-based Chemotherapy
This is a 2-arm, prospective, randomized (2:1 ratio), open-label, multi-centre, phase II study conducted in patients affected by unresectable, locally advanced or metastatic urothelial cancer receiving niraparib plus best…
- Trial name
- NCT03945084
- Testing
- Niraparib, Best supportive care
- Where
- 20 sites in Italy
- Volunteers
- 58 people
- Sponsor
- University of Turin, Italy
Cholangitis
Best Biliary Drainage Option in Advanced Klatskin Tumor
To investigate the biliary drainage-related cholangitis and other complications of percutaneous transhepatic biliary drainage (PTBD) in the management of Klatskin tumor (KT) compared with endoscopic biliary drainage (EBD).
- Trial name
- NCT03104582
- Testing
- ERCP Drainage, PTBD Drainage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
NSCLC
Trial for Local Ablative Treatment (LAT) Optimization in Patients With Advanced Non-Small Cells Lung Cancer (NSCLC) Presenting an Anaplastic Lymphoma Kinase (ALK) Rearrangement Treated by Brigatinib
The goal of this clinical trial is to learn if the treatment by systemic Brigatinib (ALUNBRIG®) associated to local ablative therapy (LAT) treatment is improved if administered when the brigatinib works best in participants…
- Trial name
- OPTALK (NCT06620835)
- Testing
- Blood samples for Hematology, Blood samples for Chemistry, Blood sample for liver function tests
- Where
- 27 sites in France
- Volunteers
- 45 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie
Arrhythmia
Trial of a Best-Practice Alert in the Electronic Medical Record to Reduce Unnecessary Telemetry Monitoring
This is a randomized trial of a best-practice alert delivered via the electronic medical record (Apex) to physicians on the Medicine service at UCSF Medical Center over a six month period.
- Trial name
- NCT02529176
- Testing
- Best-practice alert
- Volunteers
- 1,021 people
- Sponsor
- University of California, San Francisco
Pancreatic Cancer
The Efficacy and Safety of K-001 in the Treatment of Advanced Pancreatic Cancer
No Standard therapy has been approved for third-line therapy of advanced pancreatic cancer. K001 is peptidoglycan prepared from the marine microorganism, with an anti-tumor activity.
- Trial name
- NCT04183478
- Testing
- K-001
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Myelodysplastic Syndromes
Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)
Myelodysplastic syndromes (MDS) are acquired clonal disorders of the bone marrow. The clinical consequences of MDS are bone marrow failure and a predisposition to develop acute myeloid leukaemia (AML).
- Trial name
- NCT00234143
- Testing
- Darbepoetin and Filgrastim, Darbepoetin
- Where
- United Kingdom
- Volunteers
- 360 people
- Sponsor
- St. Bartholomew's Hospital
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Preterm Birth, Pregnancy
An Electronic Medical Record Alert of Progesterone
Progesterone can be given to women at risk for preterm birth, and is advocated by many guidelines as progesterone has been shown to markedly decrease preterm birth, death in newborns, and disability.
- Trial name
- NCT03219489
- Testing
- Electronic medical record alert
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- McMaster University
Liver Cancer
Comparison of Brivanib and Best Supportive Care to Placebo for Treatment of Liver Cancer for Those Subjects Who Have Failed Sorafenib Treatment
The purpose of this study is to determine if Brivanib is an effective treatment for liver cancer in patients who have failed or could not take Sorafenib
- Trial name
- BRISK PS (NCT00825955)
- Testing
- Brivanib, Best Supportive Care
- Where
- 113 sites in United States, Argentina and 17 more
- Volunteers
- 587 people
- Sponsor
- Bristol-Myers Squibb
Ménière's Disease
Pharmacokinetic Profile of Betahistine With and Without Selegiline in Healthy Volunteers
The goal of this pharmakokinetic trial is to demonstrate that Betahistine serum concentration is higher after combination treatment with Betahistine and Selegiline compared to Betahistine alone.
- Trial name
- PK-BesT (NCT05938517)
- Testing
- Betahistine dihydrochloride, Selegiline-hydrochloride
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Bronchiectasis
Clinical Outcomes of BronchiEctaSis in Taiwan: A Multicenter Prospective Cohort (BEST Study)
Bronchiectasis is a disease characteristic by bronchial dilatation. Bronchiectasis leads to further impairment of mucociliary clearance, causing a vicious cycle of further infection and progressive airway damage, resulting in…
- Trial name
- BEST (NCT07490704)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Myelodysplastic Syndromes
A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)
The purpose of this study is to evaluate the safety and efficacy of oral azacitidine in participants with low to intermediate International Prognostic Scoring System Revised (IPSS-R) myelodysplastic syndrome (MDS).
- Trial name
- NCT05469737
- Testing
- Oral Azacitidine
- Where
- 65 sites in United States, Argentina and 15 more
- Volunteers
- 230 people
- Sponsor
- Bristol-Myers Squibb
Prematurity; Extreme, Prematurity
Breastfeeding Support and Promotion Program to Improve the Health of Premature Babies (PAP-LM)
This study evaluates the effectiveness of a breastfeeding support and promotion program to increase exclusive breastfeeding rates in the preterm group.
- Trial name
- PAP-LM (NCT06653595)
- Testing
- Programme to Support Breastfeeding
- Where
- 2 sites in Spain
- Volunteers
- 162 people
- Sponsor
- University of Barcelona
Postprandial Lipemia, Type 2 Diabetes
Mediterranean Diet and Postprandial Lipemia
The aim of this intervention study was to evaluate in type 2 diabetic patients the effects on postprandial lipemia and other metabolic parameters (in both everyday life conditions and after a standard test meal) of two diets, one…
- Trial name
- NCT00789295
- Testing
- Mediterranean diet and Low-Carbohydrates diet
- Where
- Italy
- Sponsor
- Federico II University
Non-Small Cell Lung Cancer
A Study Comparing the Combination of the Best Supportive Care Plus E7080 Versus Best Supportive Care Alone, in Patients With Advanced Lung Cancer or Lung Cancer That Has Spread, Who Have Been Previously Treated, Unsuccessfully, With at Least 2 Different Treatments
The purpose of this study is to compare the overall survival of patients receiving E7080 + Best Supportive Care (BSC) with those receiving placebo + Best Supportive Care.
- Trial name
- NCT01529112
- Testing
- Lenvatinib, BSC
- Where
- 50 sites in United States, Belgium and 5 more
- Volunteers
- 135 people
- Sponsor
- Eisai Inc.
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Peripheral Artery Disease, Intermittent Claudication
Assessing Best Medical Treatment Patterns of Patients With Symptomatic Peripheral Arterial Occlusive Disease in Germany
This proposed study will be conducted to support real-world-evidence on the extent of best medical treatment for secondary prevention of patients with symptomatic peripheral arterial occlusive disease (PAOD) for prevention of…
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- NCT03909022
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf