Clinical trials: Best Disease
Acute Ischemic Stroke Patients, Acute Ischemic Stroke
Guiding Catheters in Endovascular Stroke Therapy - Are Balloon Guided Catheters Superior?
The BEST study is an academically initiated, single-center, prospective, randomized controlled clinical trial investigating the potential advantages and disadvantages of using a guide catheter with or without a balloon in the…
- Conditions
- Acute Ischemic Stroke Patients, Acute Ischemic Stroke, Acute Ischemic Stroke AIS
- Trial name
- BEST (NCT07478042)
- Testing
- Ballon guide catheter, Guide catheter without balloon
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital Heidelberg
Pancreatic Cancer
Safety Study to Determine the Appropriate Dose of Antibody Against Tumor Cells to Best Target Patients With Pancreatic Cancer.
This no treatment research study is being done to find a safe and an appropriate dose of antibody (protein) against tumor cells to best target the cancer in people with pancreatic cancer.
- Trial name
- NCT00364364
- Testing
- Radiolabeled humanized PAM4 IgG
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hepatocellular Carcinoma
Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis
Transcatheter arterial chemoembolization (TACE) had been proved to improve the survivals for middle stage hepatocellular carcinoma (HCC), but for advanced stage HCC its' efficacy had not been proved.
- Trial name
- TACEHCC (NCT00646100)
- Testing
- transcatheter arterial chemoembolization
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Sun Yat-sen University
CLN3
Study With Batten-1 (Miglustat Liquid Formulation) to Treat Ceroid Lipofuscinosis Neuronal 3 (CLN3) Disease
The goal of this open-label, single-arm, multicenter study is to assess the efficacy and safety of Batten-1 (oral liquid formulation of miglustat) (15 mg/kg up to 600 mg/day) in approximately 27 pediatric subjects with CLN3…
- Trial name
- NCT07882290
- Testing
- Miglustat oral liquid formulation (250 mg/mL)
- Where
- 10 sites in United States, Denmark and 6 more
- Volunteers
- 27 people
- Sponsor
- Beyond Batten Disease Foundation
Neoplastic Syndromes, Hereditary
Applying Population Management Best Practices to Preventative Genomic Medicine Trial
Preventive genomic medicine, particularly identification of individuals with inherited cancer risk, can improve longevity and quality of life, yet adherence to risk management following cancer genomic testing is poor.
- Trial name
- CARE-HCS (NCT07053813)
- Testing
- Web resources, Personalized outreach
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Washington
Female Infertility
What is the Best Moment for Performing an HSG in Women With a Unfulfilled Childwish
The aim of this study is to determine whether direct tubal flushing with oil-based contrast at HSG incorporated in the fertility work-up results in 10% more ongoing pregnancies and a shorter time to pregnancy, which will…
- Trial name
- H2Oil-timing (NCT05608590)
- Testing
- Lipiodol UltraFluid
- Where
- Netherlands
- Volunteers
- 554 people
- Sponsor
- Amsterdam UMC, location VUmc
Visual Impairment, Myopia
At-home Testing Refraction Results With Best Corrected Visual Acuity (BCVA) Outcomes in Adults
This study is aimed at examining the BCVA from try-on glasses constructed from measurements from the EyeQue VisionCheck.
- Conditions
- Visual Impairment, Myopia, Hyperopia, Astigmatism
- Trial name
- NCT04820218
- Testing
- With Try-on glasses
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- EyeQue Corp.
Unresectable Gastrointestinal Stromal Tumor (GIST), Locally Advanced Gastrointestinal Stromal Tumor (GIST)
A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments
This trial is a prospective, randomized (1:1 ratio), multicenter, comparative and phase II study, conducted in patients with unresectable advanced gastrointestinal stromal tumors (GIST) after failure of imatinib (disease…
- Conditions
- Unresectable Gastrointestinal Stromal Tumor (GIST), Locally Advanced Gastrointestinal Stromal Tumor (GIST), Metastatic Gastrointestinal Stromal Tumor
- Trial name
- ATEZOGIST (NCT05152472)
- Testing
- Atezolizumab 1200 mg, Imatinib 400 MG
- Where
- 13 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Leon Berard
Asthma
Best African American Response to Asthma Drugs
The purpose of this study is to find the best asthma treatment to add for Blacks who have asthma that is not well controlled on a low dose of inhaled steroid.
- Trial name
- BARD (NCT01967173)
- Testing
- Flovent Diskus® 100 mcg, Flovent Diskus® 250 mcg, Flovent Diskus® 500 mcg
- Where
- 28 sites in United States
- Volunteers
- 574 people
- Sponsor
- Milton S. Hershey Medical Center
Cough
Promoting Safe Use of Children's Cough/Cold Medicines
This study seeks to identify ways to help parents safely use cough/cold medications with their children. The study focuses on 3 key tasks that have been found to be difficult for parents: 1) decision-making about whether…
- Trial name
- NCT03126851
- Testing
- Label
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cholangitis
Best Biliary Drainage Option in Advanced Klatskin Tumor
To investigate the biliary drainage-related cholangitis and other complications of percutaneous transhepatic biliary drainage (PTBD) in the management of Klatskin tumor (KT) compared with endoscopic biliary drainage (EBD).
- Trial name
- NCT03104582
- Testing
- ERCP Drainage, PTBD Drainage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Critical Illness, Respiratory Failure
International Observational Study on Airway Management in Critically Ill Patients
Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common.
- Conditions
- Critical Illness, Respiratory Failure, Hemodynamic Instability, Coma
- Trial name
- INTUBE (NCT03616054)
- Where
- Italy
- Volunteers
- 3,600 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
SARS-CoV 2, COVID-19
Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19
Study objective is to evaluate the efficacy of the combination of masitinib and isoquercetin in adult hospitalized patients with moderate and severe COVID-19.
- Conditions
- SARS-CoV 2, COVID-19, Coronavirus Disease 2019
- Trial name
- NCT04622865
- Testing
- Masitinib, Isoquercetin, Best Supportive Care
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- AB Science
Carcinoma, Non-Small-Cell Lung
BIBW 2992 and BSC Versus Placebo and BSC in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib (LUX-LUNG 1)
This randomized, double-blind, multi-center Phase IIb/III trial will be performed in patients with NSCLC who have received previous treatment with at least one but not more than two lines of cytotoxic chemotherapy (one line must…
- Trial name
- NCT00656136
- Testing
- BIBW 2992
- Where
- 90 sites in United States, Belgium and 13 more
- Volunteers
- 585 people
- Sponsor
- Boehringer Ingelheim
COVID-19 Severe Pneumonia, Acute Lung Injury
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia
This study evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab administered in adult participants with coronavirus disease 2019 (COVID-19) severe pneumonia, acute lung injury, or acute…
- Conditions
- COVID-19 Severe Pneumonia, Acute Lung Injury, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- NCT04369469
- Testing
- Ravulizumab, BSC
- Where
- 39 sites in United States, France and 3 more
- Volunteers
- 202 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Pre-eclampsia
New Magnesium Sulphate Protocol for Pre-eclampsia
there is a standard magnesium sulphate protocol and newer protocols for pre-eclampsia, we need to make a trial to find the best protocol
- Trial name
- NCT01846156
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Cairo University
Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI)
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.
- Conditions
- Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP), Complicated Urinary Tract Infection (cUTI)
- Trial name
- CREDIBLE - CR (NCT02714595)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 85 sites in United States, Brazil and 14 more
- Volunteers
- 152 people
- Sponsor
- Shionogi
Blood Pressure, End Stage Renal Disease
How to Get a Better Dry Weight in End-stage Renal Disease (ESRD) Population for Improving Blood Pressure Control
End-stage renal disease (ESRD) is a common clinical condition. In this population, the prevalence of systemic hypertension is high and its adequate control can determinate the outcome.
- Conditions
- Blood Pressure, End Stage Renal Disease, Hemodialysis
- Trial name
- NCT01104909
- Testing
- Clinical, electrical bioimpedance
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade de Passo Fundo
Foot Ulcer, Diabetic
The Sorbact® Antimicrobial Dressing in the Holistic Wound Management Of Diabetic Foot ulCers (Phase III Study)
The aim of this study is to demonstrate, during a 12-week follow-up, a greater efficacy of using Sorbact® dressing technology in addition to best local cares compared to best local cares alone in the management of diabetic foot…
- Trial name
- ADHOC (NCT02334241)
- Testing
- Sorbact®, Best local cares
- Where
- 15 sites in Czechia, France and 1 more
- Volunteers
- 200 people
- Sponsor
- INRESA Pharma