Clinical trials: Best Disease
Steroid-refractory Acute Graft-versus-host Disease
Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease
The purpose of this trial is the comparative evaluation of overall response rate (ORR) in paediatric participants with steroid-refractory acute graft-versus-host disease (SR-aGvHD) at Visit Day 28 after treatment with MC0518 or…
- Trial name
- BALDER (NCT06075706)
- Testing
- MC0518, BAT
- Where
- 36 sites in France, Germany and 3 more
- Volunteers
- 49 people
- Sponsor
- medac GmbH
Metastatic Colorectal Carcinoma
A Study to Estimate Overall Survival in Patients Receiving Best Supportive Care for Treatment-Resistant, Metastatic Colorectal Carcinoma
The primary objective of this study is to estimate overall survival in patients only receiving best supportive care (BSC) for treatment-resistant, metastatic colorectal carcinoma.
- Trial name
- NCT03096899
- Testing
- Observational
- Where
- United States
- Sponsor
- The Rogosin Institute
Metastatic Colorectal Cancer (mCRC)
Evaluation of a Diagnostic Test to Identify the Best Drugs for Treatment of Metastatic Colorectal Cancer
DSEE-CRC is a top-tier Norwegian and Swedish public-private partnership for the development of µCAN, a unique patient-centric, therapy-guiding in vitro diagnostic test to improve cancer treatment outcomes for metastatic…
- Trial name
- DSEE-CRC (NCT07171554)
- Testing
- µCAN drug screen test, Standard-of-Care Therapy
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oncosyne AS
Wet Age Related Macular Degeneration
Safety and Tolerability of Ranibizumab in Mono/Bilateral Wet Age Related Macular Degeneration (w-AMD) Patients in Eyes With BCVA<2/10 and/or 2nd Affected Eye
The purpose of this study is to evaluate the safety and efficacy of ranibizumab in patients affected by wet age related macular degeneration (wAMD).
- Trial name
- TWEYES (NCT01986907)
- Testing
- ranibizumab
- Where
- 101 sites in Italy
- Volunteers
- 1,049 people
- Sponsor
- Novartis Pharmaceuticals
Palliative Care, Kidney Failure, Chronic
A Communication Tool to Assist Older Adults Facing Dialysis Choices
The purpose of this study is to test the effect of the "Best Case/Worse Case" (BC/WC) communication tool on receipt of palliative care and intensity of treatment at the end of life, quality of life, and quality of communication…
- Conditions
- Palliative Care, Kidney Failure, Chronic, Decision Making, Decision Support Techniques
- Trial name
- NCT04466865
- Testing
- Best Case/Worst Case communication tool training
- Where
- 11 sites in United States
- Volunteers
- 407 people
- Sponsor
- University of Wisconsin, Madison
Colorectal Cancer, Liver Metastases
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases
To evaluate if the addition of liver transplantation primarily utilizing liver grafts from extended criteria donors not utilized for approved indications to conventional treatment of non-resectable/ non-abatable colorectal liver…
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Liver Metastases
- Trial name
- SOULMATE (NCT04161092)
- Testing
- Liver transplantation Ltx, Best alternative care
- Where
- 2 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Vastra Gotaland Region
Gastric Cancer, Gastric Adenocarcinoma
A Study to Evaluate Rivoceranib Plus Best Supportive Care Compared to Placebo Plus Best Supportive Care in Participants With Gastric Cancer
The purpose of this study is to evaluate the efficacy and safety of rivoceranib plus best supportive care (BSC) compared to placebo plus BSC in participants with advanced or metastatic gastric cancer (GC).
- Trial name
- ANGEL (NCT03042611)
- Testing
- Rivoceranib
- Where
- 95 sites in United States, France and 10 more
- Volunteers
- 460 people
- Sponsor
- Elevar Therapeutics
Asthma
SOLO-Symbicort® in the Treatment of Persistent Asthma in Adolescents & Adults
The purpose of this study is to compare Symbicort Single Inhaler treatment with the Best Conventional Practice in patients with persistent asthma
- Trial name
- NCT00238784
- Testing
- Budesonide/formoterol Turbuhaler
- Where
- 3 sites in Canada
- Volunteers
- 1,300 people
- Sponsor
- AstraZeneca
Stroke, Ischemic Stroke
EndoVascular Treatment With Stent-retriever and/or Thromboaspiration vs. Best Medical Therapy in Acute Ischemic Stroke
Prospective, multi-center, randomized, controlled, open, blinded-endpoint trial with a sequential design. The randomization employs a 1:1 ratio of mechanical thrombectomy with stentriever and/or Thromboaspiration versus medical…
- Trial name
- RESILIENT (NCT02216643)
- Testing
- Thrombectomy, Stentriever Solitaire FR® or Penumbra System®
- Where
- 15 sites in Brazil
- Volunteers
- 221 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life.
- Trial name
- GREAT-HF Care (NCT05990296)
- Testing
- Multiprong CDS with referral to pharmacist co-management, Multiprong CDS with GDMT order set, Focused education
- Where
- United States
- Volunteers
- 4,306 people
- Sponsor
- Geisinger Clinic
Solid Tumors, Breast Cancer
A Study To Find The Best Doses Of SU011248 (Sunitinib) And Capecitabine When These Drugs Are Administered Together
This study assesses the maximum tolerated dose, overall safety and antitumor activity of SU011248 in combination with capecitabine in patients with advanced solid tumors
- Conditions
- Solid Tumors, Breast Cancer, Neoplasms
- Trial name
- NCT00618124
- Testing
- SU011248; Capecitabine
- Where
- 3 sites in United States
- Volunteers
- 77 people
- Sponsor
- Pfizer
Pancreatic Cancer
The Efficacy and Safety of K-001 in the Treatment of Advanced Pancreatic Cancer
No Standard therapy has been approved for third-line therapy of advanced pancreatic cancer. K001 is peptidoglycan prepared from the marine microorganism, with an anti-tumor activity.
- Trial name
- NCT04183478
- Testing
- K-001
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Ménière's Disease
Pharmacokinetic Profile of Betahistine With and Without Selegiline in Healthy Volunteers
The goal of this pharmakokinetic trial is to demonstrate that Betahistine serum concentration is higher after combination treatment with Betahistine and Selegiline compared to Betahistine alone.
- Trial name
- PK-BesT (NCT05938517)
- Testing
- Betahistine dihydrochloride, Selegiline-hydrochloride
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Vulvar Cancers
A PHASE II, RANDOMIZED TRIAL TO ASSESS MAINTENANCE THERAPY WITH CEMIPLIMAB VERSUS BEST SUPPORTIVE CARE AFTER 1ST LINE PLATINUM-BASED CHEMOTHERAPY IN ADVANCED/RECURRENT VULVAR CANCER
This is a phase II, randomized study that will include 42 participants who have received 4 to 6 cycles of first-line platinum-based chemotherapy for advanced vulvar squamous cell carcinoma (SCC) not amenable to curative surgical…
- Trial name
- BRAVA VULVAR (NCT07101848)
- Testing
- Cemiplimab
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Hospital Israelita Albert Einstein
Eating Disorders, Bulimia
Guided Self-Help Treatment for Binge Eating Disorder
This study will determine the effectiveness of guided self-help treatment in treating individuals with binge eating disorder (BED).
- Trial name
- BEST (NCT00158340)
- Testing
- Guided self-help cognitive behavioral therapy (CBT), Usual clinical care
- Where
- 2 sites in United States
- Volunteers
- 284 people
- Sponsor
- Kaiser Permanente
Malignant Pleural Mesothelioma
NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed
The main objective of the trial is to document the efficacy of NGR-hTNF administered at low dose weekly in advanced Malignant Pleural Mesothelioma patients previously treated with a pemetrexed-based chemotherapy regimen.
- Trial name
- NCT01098266
- Testing
- NGR-hTNF plus Best Investigator's Choice (BIC)
- Where
- 49 sites in United States, Belgium and 10 more
- Volunteers
- 400 people
- Sponsor
- AGC Biologics S.p.A.
Recurrent Platinum-sensitive Ovarian Cancer
Evaluation of Optimal Treatment With Bevacizumab in Patients With Platinum-sensitive Recurrent Ovarian Cancer
Evaluation of the best therapeutic index for patients with platinum-sensitive ovarian cancer when treatment with bevacizumab and gemcitabine/carboplatin or with bevacizumab and PLD/carboplatin.
- Trial name
- NCT01837251
- Testing
- Carboplatin, PLD, Bevacizumab
- Where
- 193 sites in Australia, Austria and 4 more
- Volunteers
- 682 people
- Sponsor
- AGO Research GmbH
Sickle Cell Disease
Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABIT
The investigators propose that culturally aligned community-based interventions in our multi-ethnic sickle cell disease (SCD) population, augmented by task-focused communication technology, can improve self-managed adherence to…
- Trial name
- HABIT (NCT02029742)
- Testing
- Community Health Worker (CHW), Education
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Blood Pressure, End Stage Renal Disease
How to Get a Better Dry Weight in End-stage Renal Disease (ESRD) Population for Improving Blood Pressure Control
End-stage renal disease (ESRD) is a common clinical condition. In this population, the prevalence of systemic hypertension is high and its adequate control can determinate the outcome.
- Conditions
- Blood Pressure, End Stage Renal Disease, Hemodialysis
- Trial name
- NCT01104909
- Testing
- Clinical, electrical bioimpedance
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade de Passo Fundo
Cerebral Palsy
Investigating Best Practices for Children With Cerebral Palsy: A Pilot Study of Two Approaches
This project (CO-OP II) is the second in a series of three studies to validate a new treatment approach for children with cerebral palsy (CP).
- Trial name
- NCT00430131
- Testing
- Cognitive Orientation to Occupational Performance, Contemporary Treatment Approach
- Volunteers
- 18 people
- Sponsor
- University of Toronto