Clinical trials: Beta Blockers
Heart Failure, Congestive
Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure
Beta-blocker medications have been shown to improve heart function and prolong the lives of patients with chronic heart failure (CHF).
- Trial name
- NCT00077948
- Testing
- Enoximone, Metoprolol succinate
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Gilead Sciences
Heart Failure, Polygenic Score
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent.
- Trial name
- UPBEAT (NCT07054489)
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- David Lanfear
Opioid Use, Unspecified, Anesthesia
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
This study aims to evaluate esmolol's perfusion impact during induction and maintenance of general anesthesia, using Nociception-Level-guided control of nociception, in adult patients undergoing laparoscopic and lower abdominal…
- Conditions
- Opioid Use, Unspecified, Anesthesia, Nociceptive Pain
- Trial name
- ESMONOL (NCT06291363)
- Testing
- Esmolol Hydrochloride, Saline
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Coronary Bypass Graft Surgery, Atrial Fibrillation
Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG
Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients.
- Trial name
- NCT03871647
- Testing
- Beta blocker
- Where
- Egypt
- Volunteers
- 256 people
- Sponsor
- Ain Shams University
Heart Failure, Congestive
Beta-Blocker Continuation Versus Interruption in Heart Failure Worsening
The objective of the B-Convinced study is to demonstrate the non-inferiority of beta-blocker continuation compared to its interruption in patients with congestive heart failure who are treated by a beta-blocker and present with…
- Trial name
- BConvinced (NCT00162565)
- Testing
- beta-blocker treatment
- Where
- 32 sites in France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long QT Syndrome, Hypoglycemia
Frequency of Hypoglycemia in Children With Beta-blocker Treated Long QT-syndrome
The goal of this observational study is to investigate the frequency and characteristics of hypoglycemic episodes in children with long QT syndrome (LQTS) and beta-blocker treatment, specifically those receiving propranolol…
- Trial name
- LQThypo (NCT07233421)
- Testing
- Continuous Glucose Monitoring
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Cardiac Surgery
Esmolol in Cardiac Surgery
This large randomized double-blind clinical trial (esmolol vs placebo) will enroll patients undergoing cardiac surgery to study the additive cardiac protection of this therapeutic strategy.
- Trial name
- BREVI (NCT00959569)
- Testing
- Esmolol
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università Vita-Salute San Raffaele
Gastric Varix, Cirrhosis
EUS-guided Combined Therapy Versus Beta Blocker Therapy in Primary Prophylaxis o GOV II and IGV I
The EUS-guided combined therapy of coilingand 2-octyl-cyanoacrylate in patients with gastric varices reduced rebleeding and need for reintervention in comparison to EUS-guided coiling alone.The purpose of this study is to…
- Conditions
- Gastric Varix, Cirrhosis, GastroIntestinal Bleeding
- Trial name
- NCT04075760
- Testing
- Coils + Cyanoacrylate Group + beta-blocker, beta blocker therapy
- Where
- Ecuador
- Volunteers
- 26 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure
Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App)
This study will look at whether using a phone app called StudyU can help people with Heart Failure with Reduced Ejection Fraction (HFrEF) reach their recommended dose on their beta blocker.
- Conditions
- HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure, Heart Failure, Systolic, Heart Diseases
- Trial name
- N-of-1 App (NCT07252310)
- Testing
- beta blockers, StudyU Application
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Weill Medical College of Cornell University
Glaucoma,Open-Angle, Ocular Hypertension
Non Interventional Study in Patients With Open Angle Glaucoma and/or Ocular Hypertension Treated With XALATAN®
The primary objective is to evaluate the Intraocular pressure reducing effect of Xalatan over 3 months. The secondary objective is to study the other efficacy parameters during treatment for 3 months
- Trial name
- NCT00486252
- Testing
- Observational
- Volunteers
- 996 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Coronary Disease, Atrial Fibrillation
Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery
Postoperative new-onset atrial fibrillation (AF) is the most common complication stemming from coronary artery bypass graft surgery, and is associated with increased early and late mortality risk.
- Trial name
- NCT00198614
- Testing
- Carvedilol versus Metoprolol
- Where
- Japan
- Volunteers
- 650 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Ocular Hypertension, Glaucoma
Tolerance and Effect on Intraocular Pressure After Administration of SYL040012
The purpose of this study is to determine whether SYL040012 is safe for the treatment of ocular hypertension and glaucoma.
- Trial name
- NCT00990743
- Testing
- SYL040012
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Myocardial Infarct
STunning in Acute Myocardial Infarction - BAS
The objective of this trial is to examine the effect of immediate versus late administration of beta blockers, angiotensin converting enzyme inhibitors (ACEI), and sodium/glucose cotransporter 2 (SGLT2) inhibitors on…
- Trial name
- STAMI-BAS (NCT06562582)
- Testing
- Bisoprolol Oral Tablet, Ramipril Oral Product, Dapagliflozin Oral Product
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Coronary Artery Bypass
WithDRawal Impact Of Postoperative Beta-Blocker
The investigators will evaluate the impact of withdrawing beta-blocker medication after coronary artery bypass surgery with this randomized controlled trial.
- Trial name
- DROP-BB (NCT05414331)
- Testing
- Discontinuing all beta-blocker
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Yale University
Stroke, Cerebrovascular Disorders
Propranolol on Post Stroke Immune Status and Infection
Stroke-associated pneumonia (SAP) is one of the important risk factors influencing poor outcomes and death in stroke patients. Over the past two decades, accumulating evidence suggests that post-stroke brain injury mobilizes the…
- Conditions
- Stroke, Cerebrovascular Disorders, Ischemic Stroke, Brain Diseases
- Trial name
- NCT05375240
- Testing
- Propranolol, Ceftriaxone
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- Tianjin Medical University General Hospital
Postoperative Pain
Genetic Predictors of Analgesic Efficacy of Propranolol for Treating Postoperative Pain
This study is a randomized, double-blind, placebo controlled clinical trial. The main purpose of this study is to determine if postsurgical pain ratings are improved with treatment with oral Propranolol, and if the effectiveness…
- Trial name
- PRO_GENE_POP (NCT02511483)
- Testing
- Propranolol PO, IV-PCA morphine, Quantitative Sensory Testing (QST)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease
Beta-Blocker in Chronic Obstructive Pulmonary Disease (COPD) Study
Smoking causes both smoking related lung disease (COPD) and ischaemic heart disease. These are very common conditions and many patients have both diseases.
- Trial name
- BOLD (NCT00745043)
- Testing
- bronchodilator response
- Where
- New Zealand
- Volunteers
- 11 people
- Sponsor
- Waikato Hospital
Hypertension
The Effect of Nebivolol on Insulin Sensitivity
The purpose of this study is to conduct a randomised trial to compare the insulin sensitivity, 24 hour blood pressure profile, and tolerability of nebivolol plus a thiazide-like diuretic versus atenolol plus a thiazide-like…
- Trial name
- NCT00125853
- Testing
- Nebivolol, Atenolol
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Imperial College London
Stress, Psychological, Inflammation
Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
This randomized, double-blind, placebo-controlled study of propranolol will shed important light on how sympathetic nervous system (SNS) activation influences psychological and inflammatory responses to acute stress.
- Conditions
- Stress, Psychological, Inflammation, Cortisol, Sympathetic Nervous System
- Trial name
- NCT02972554
- Testing
- Propanolol hydrochloride
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill