Clinical trials: Beta Lactam Allergy
Allergy Amoxicillin, Beta-lactam Allergy Labels
The Implementation and Impact of an Allergy De-Labeling Program in the Emergency Department
Beta-lactams are the most common antibiotics prescribed to children, including penicillin and amoxicillin. They are usually more effective and have fewer side effects than other ty antibiotics.
- Trial name
- NCT06823154
- Testing
- Amoxicillin, Study questionnaire
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- The Hospital for Sick Children
Allergic Reaction, Beta Lactam Adverse Reaction
Investigation of Cross-allergies Between Cefazolin and Amoxicillin With Skin Tests and Provocation Test
Antibiotic prophylaxis in the operating room reduces the frequency of occurrence of surgical site infections (SSI) by preventing bacterial proliferation. The main antibiotic used in all surgery is CEFAZOLINE.
- Trial name
- CEFAZOPE (NCT05605795)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Beta Lactam Allergy in Patients With a Hematologic Malignancy
Allergy Delabeling in Antibiotic Stewardship - Evaluations
The goal of this RENEW-EVAL project is to understand the potential barriers to implementation of the RENEW intervention into the routine clinical care of patients with a hematological malignancy.
- Trial name
- RENEW-EVAL (NCT06967467)
- Testing
- Semi-structured interview, Survey, Ethnographic observation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Beta-Lactams Allergy, Hypersensitivity
Genomic Study of Genetic Polymorphisms Involved in Immediate Allergic Reactions to Beta-lactam Antibiotics
Beta-lactam antibiotics include penicillin and cephalosporins and are among the most prescribed antibiotics. This category of drugs is the most involved in immediate allergic manifestations with 2% reactions in treated subjects…
- Trial name
- PANGENOMIC-BL (NCT02895646)
- Testing
- Collection of blood sample
- Volunteers
- 2,356 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Allergy
Direct Oral Challenges in Private Practice Setting to Delabeling Children With Beta-lactam Allergy
The purpose of this study is to demonstrate the feasibility of direct oral challenge performed in private practice setting for children with suspected benign delayed allergy to beta-lactams.
- Trial name
- Betalactaville (NCT07002814)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Penicillin Allergy
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams
This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.
- Trial name
- NCT00789217
- Testing
- Immediate skin test
- Where
- Thailand
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Allergy
Negative Predictive Value and NIC of Beta-Lactam Antibiotics.
The researchers are trying to evaluate how much medication is required for allergy skin testing and to determine the likelihood that patients with a negative test truly don't have an allergy to the tested drug of skin testing to…
- Trial name
- NCT04126096
- Testing
- Skin Testing beta-lactams
- Where
- 2 sites in United States
- Volunteers
- 747 people
- Sponsor
- Mayo Clinic
Drug Hypersensitivity
Negative Predictive Value of Drug Provocation Tests to Beta-lactams
Patients with a complete drug allergy work-up to betalactam antibiotics were contacted (by mail) and asked to answer a questionnaire regarding the tolerance upon readministration of a negatively tested beta-lactam.
- Trial name
- NPVDPT (NCT02844712)
- Testing
- Evaluation of reexposure to a negatively tested betalactam
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Montpellier
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IgE-Mediated Hypersensitivity, Allergy
Safety of Ertapenem in Beta-lactam Allergic Patients.
The purpose of this study is to assess cross-reactivity and tolerability of ertapenem in patients with IgE-mediated allergy to at least one beta-lactam molecule.
- Trial name
- NCT01159379
- Testing
- ertapenem
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Pharmacokinetics, Beta Lactam Adverse Reaction
Beta-lactam Pharmacokinetics in Secondary Care
Currently in the UK, TDM is routinely performed for aminoglycosides and glycopeptide antimicrobial agents, given fears over the narrow therapeutic window of these agents and the serious adverse events associated with toxicity.
- Conditions
- Pharmacokinetics, Beta Lactam Adverse Reaction, Penicillin Allergy
- Trial name
- NCT03033394
- Testing
- Beta-lactam antibiotic
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Imperial College London
Beta-lactam Allergy
Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment
Beta-lactam allergy is the most prevalent drug allergy. Drug eruption is the most common symptom whereas life-threatening anaphylaxis is rather rare.
- Trial name
- NCT01520181
- Testing
- Beta-lactam oral challenge
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Drug Hypersensitivity
Optimal Doses for Drug Provocation Tests to Beta-lactams
Drug provocation tests (DPT) are widely in case of suspicion of drug hypersensitivity (and in the absence of contraindications), but there are no standardized protocols and most groups use hypothesis (clinically-driven)…
- Trial name
- NewBL (NCT02839551)
- Testing
- simplified drug provocation test
- Where
- France
- Volunteers
- 1,252 people
- Sponsor
- University Hospital, Montpellier
Beta Lactam Allergy, Hematologic Malignancy
Allergy Delabeling in Antibiotic Stewardship - Intervention
The overall goal of the RENEW-IN intervention is to assess the impact of a BL allergy delabeling intervention on antibiotic use and clinical outcomes in patients with a hematologic malignancy.
- Trial name
- RENEW-IN (NCT07133074)
- Testing
- RENEW-IN Algorithm for assessment of a beta-lactam intervention, EMR Review
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pulmonary Tuberculosis
Trial of Faropenem and Cefadroxil (in Combination With Amoxicillin/Clavulanic Acid and Standard TB Drugs) in Patients With Pulmonary Tuberculosis: Measurement of Early Bactericidal Activity and Effects on Novel Biomarkers
This trial aims to determine whether the early bactericidal activity of rifampicin given with faropenem or cefadroxil (each given with amoxicillin/clavulanic acid) is greater than the activity of rifampicin alone in patients with…
- Trial name
- NCT02381470
- Testing
- Faropenem, Amoxicillin/clavulanic acid, Cefadroxil
- Where
- 6 sites in Philippines, Singapore and 1 more
- Volunteers
- 58 people
- Sponsor
- National University Hospital, Singapore
Drug Allergy, Cephalosporin Allergy
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in…
- Conditions
- Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy
- Trial name
- DACAT (NCT06406114)
- Testing
- Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Penicillin Allergy, In-hospital Process Optimization
A Digital Stewardship Strategy for Patients With Reported Penicillin Allergy
The goal of this clinical study is to evaluate whether a digital decision support tool integrated into the electronic medical record improves antibiotic prescribing in hospitalized patients with a reported allergy to penicillin.
- Trial name
- Digitalpen (NCT07604597)
- Where
- Spain
- Volunteers
- 182 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Hypersensitivity, Beta Lactam Adverse Reaction
Protocol of Reintroduction of Beta-lactams in Children at Low Risk of Anaphylaxis.
The purpose of this study is to establish the rationale for the practice of performing an oral reintroduction test without previous skin tests in children at low risk of IgE-mediated reaction or drug-induced toxidermia, and to…
- Trial name
- TRO-b-lact (NCT03553251)
- Where
- France
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Surgical Site Infection, Beta-lactam Allergy
Prophylactic Antibiotics for Surgical Site Infections and Beta-Lactam Allergy
Postoperative surgical site infection (SSI) is associated with unnecessary use of heath care resources including prolonged hospitalization and increased hospital readmission.
- Trial name
- NCT04401553
- Testing
- cephalosporin, Second tier antibiotic (Vancomycin)
- Sponsor
- University of Texas Southwestern Medical Center
Drug Allergy
In Search of the Correct Diagnosis of Beta-lactam Allergy: From the Validation of a Risk Stratification Tool to Accurate Endotyping
Testing a clinical decision tool (BL-Predictor)
- Trial name
- Allergy (NCT07011212)
- Testing
- BL-Predicter
- Volunteers
- 332 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud