Clinical trials: Bilateral Retinoblastoma
Retinoblastoma, Retinoblastoma Bilateral
Retinoblastoma Patient Clinical Database and Tissue Repository
Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed.
- Conditions
- Retinoblastoma, Retinoblastoma Bilateral, Retinoblastoma Unilateral
- Trial name
- NCT04959097
- Where
- 9 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Children's Hospital Los Angeles
Retinoblastoma, Retinoblastoma Bilateral
Autonomic Reflexes During Intra-arterial Chemotherapy for Retinoblastoma
Prospective observational study in patients undergoing intra-arterial ophthalmic artery chemotherapy for the treatment of retinoblastoma.
- Conditions
- Retinoblastoma, Retinoblastoma Bilateral, Chemotherapy Effect
- Trial name
- NCT04451304
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
Retinoblastoma
Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma
RATIONALE: Drugs used in chemotherapy, such as carboplatin, etoposide, and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00110110
- Testing
- filgrastim, Carboplatin, Cyclosporine
- Where
- 6 sites in Canada, Chile and 2 more
- Volunteers
- 71 people
- Sponsor
- The Hospital for Sick Children
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Surgery--Complications, Retinoblastoma Bilateral
Sutures in Orbital Implants in Retinoblastoma Patients
The purpose of this study is to evaluate different sutures for orbital implants in retinoblastoma patients.
- Trial name
- NCT04383860
- Testing
- 5-0 suture, 4-0 suture
- Volunteers
- 132 people
- Sponsor
- Sun Yat-sen University
Retinoblastoma
Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma
The purpose of this trial is to evaluate proton beam radiation therapy as an alternative to external photon beam irradiation in children with retinoblastoma as a means of local tumor control and ocular retention.
- Trial name
- NCT00432445
- Testing
- Proton Beam Radiation Therapy, Ophthalmic EUA
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Retinoblastoma
Pilot Study of Topotecan/Vincristine With Subconjunctival Carboplatin for Patients With Bilateral Retinoblastoma
The investigators are testing subtenon carboplatin in combination with vincristine and topotecan given by vein in the hopes of finding a drug combination that may be effective against retinoblastoma that has come back (recurrent)…
- Trial name
- RELRB1 (NCT00980551)
- Testing
- subtenon Carboplatin, Topotecan Hydrochloride, Vincristine
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma
A Study to Give Treatment Inside the Eye to Treat Retinoblastoma
This phase II trial tests the safety and side effects of adding melphalan (by injecting it into the eye) to standard chemotherapy in early treatment of patients with retinoblastoma (RB).
- Conditions
- Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma, Group D Retinoblastoma, Stage I Retinoblastoma
- Trial name
- NCT05504291
- Testing
- Biospecimen Collection, Carboplatin, Etoposide
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 26 people
- Sponsor
- Children's Oncology Group
Retinoblastoma Bilateral, Retinoblastoma Unilateral
Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.
The goal of this observational study is undertake a detailed phenotypic and genotypic study of patients with ocular and secondary cancers due to mutations in the RB1 gene.
- Conditions
- Retinoblastoma Bilateral, Retinoblastoma Unilateral, Retinoblastoma, Extraocular, Retinoblastoma, Recurrent
- Trial name
- NCT06725173
- Testing
- Targeted Long-read sequencing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington