Clinical trials: Bilateral Total Knee Arthroplasty
Osteoarthritis
Bilateral Total Knee Arthroplasty vs Unicompartment Arthroplasty Retrospective and Clinical Outcome Study
To determine if there is a patient satisfaction preference of Total Knee Arthroplasty (TKA) vs Unicompartmental Knee Arthroplasty (UKA) in patients with bilateral knee osteoarthritis who underwent a primary TKA one side and a…
- Trial name
- NCT02583113
- Testing
- Total and Unicompartment Knee Replacement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital
Osteoarthritis
Evaluation of Diprospan Injection to the Knee on Rehabilitation of Patients After TKR of the Contralateral Knee
This study is performed to assess the influence of intraarticular injection of 2ml Diprospan (wich contains 4mg Betamethasone sodium phosphate and 10mg Betamethasone dipropionate) into osteoarthritic knee in patients who undergo…
- Trial name
- NCT00542139
- Testing
- Betamethasone, Bupivocaine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Surgical Wound, Bilateral Total Knee Arthroplasty
Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA
This study will compare the effects of closed incision negative pressure dressing vs. standard of care silver dressing on lower limb swelling after bilateral primary total knee arthroplasty.
- Conditions
- Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases
- Trial name
- ENABLE (NCT04712019)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Solventum US LLC
Knee Arthropathy
Comparison of Balance and Fall Risk in Unilateral and Bilateral Total Knee Arthroplasty
Static or dynamic postural control cannot be fully restored in patients with Total Knee Arthroplasty (TKA). Moreover, deficits in balance and postural control may still be present in both extremity after TKA.
- Trial name
- NCT04796519
- Testing
- Total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Pamukkale University
Knee Osteoarthritis
Staged Versus Simultaneous Bilateral Knee Arthroplasty
The purpose of this study is to assist surgeons and patients in answering the question "Should I have both knees replaced at the same time, or should I just do one and wait to do the second one?"
- Trial name
- NCT03564730
- Testing
- Simultaneous Knee Arthroplasty (UKA), Staged Knee Arthroplasty (UKA)
- Where
- 8 sites in Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
Postoperative Inflammatory Response
Steroids in Bilateral Total Knee Replacement
Inflammation related to cytokine release is known to occur with surgery. The cytokine IL6, a major marker of inflammation is known to increase during total joint replacement surgery.
- Trial name
- NCT01399268
- Testing
- Hydrocortisone, Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Anemia, Knee Osteoarthritis
Effect of Preoperative Ferric Carboxymaltose After Simultaneous Bilateral Total Knee Arthroplasty
The primary purpose of this study is to evaluate the safety and efficacy of preoperative intravenous ferric carboxymaltose in patients with anemia undergoing Simultaneous Bilateral Total knee replacement in terms of Quality of…
- Conditions
- Postoperative Anemia, Knee Osteoarthritis, Total Knee Arthroplasty
- Trial name
- NCT03561506
- Testing
- Ferric carboxymaltose, 0.9% Normal Saline
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Arthropathy of Knee
Comparative Effect of Mechanical and Functional Alignment in Bilateral Total Knee Arthroplasty on Ankle Alignment
Mechanical alignment (MA) in total knee arthroplasty (TKA) is the most commonly used with well-documented long-term results, however 20% of patients express dissatisfaction following primary TKA.
- Trial name
- NCT06259032
- Testing
- Mechanical alignment, Functional alignment
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Pain, Postoperative
Comparison of Outcomes Between Intraosseous Femoral and Tibial Injection in Simultaneous Bilateral Total Knee Arthroplasty Patients
In patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (TKA) is the operation that increases the quality of life for the patient.
- Trial name
- NCT06243575
- Testing
- Multimodal Intraosseous Femoral Injection, Multimodal Intraosseous Tibial Injection
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Postoperative Anemia, Knee Osteoarthritis
Effect of Postoperative Ferric Carboxymaltose
The primary purpose of this study is to evaluate the safety and efficacy of postoperative intravenous ferric carboxymaltose in patients with anemia undergoing Simultaneous Bilateral Total knee replacement in terms of Quality of…
- Conditions
- Postoperative Anemia, Knee Osteoarthritis, Total Knee Arthroplasty
- Trial name
- NCT03561480
- Testing
- Ferric carboxymaltose, 0.9% Normal Saline
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Degenerative Arthritis
Gastric Volume in Diabetic Patients Undergoing Staged Bilateral Total Knee Arthroplasty
Aspiration of gastric contents during perioperative period is a grave complication with significant morbidity and mortality. Diabetic patients have a higher incidence of autonomic dysfunction, causing gastropathy.
- Trial name
- NCT04815070
- Testing
- Ultrasonic measurement of antral area
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Bundang Hospital
Knee Osteoarthritis
Population Pharmacokinetics of Ropivacaine
The aim of this study was to investigate the pharmacokinetics of free and total ropivacaine after unilateral and bilateral TKA. A population model was successfully built and peak free ropivacaine concentration stayed below…
- Trial name
- NCT04702282
- Testing
- ropivacain concentration measurements
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital
Total Knee Anthroplasty, Osteoarthritis(Primary)
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA.
- Conditions
- Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
- Trial name
- COSTI (NCT06809998)
- Testing
- Corticosteroid Injection - 80mg methylprednisolone (total volume 2ml) with 6 mL of 1% Bupivacaine without epinephrine (Total Volume 8 mL)., Band-Aid
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Non-inflammatory Arthritis
Does Implant Design Improve Postoperative Flexion?
This study will evaluate whether design features of one implant design allows more knee bend than the other. Patients will have 1 design in the left knee and 1 design in their right knee.
- Trial name
- NCT00380861
- Testing
- Total knee replacement using the PFC Sigma RPF knee implant., Total knee replacement using the PFC Sigma RP knee implant
- Where
- 4 sites in United States
- Volunteers
- 93 people
- Sponsor
- DePuy Orthopaedics
Difference Between Femoral Nerve Block and Saphenous Block
Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural to provide long-lasting pain relief with or without a femoral nerve block (FNB).
- Trial name
- NCT01505374
- Testing
- Study Technique, Control Technique
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Replacement, Postoperative Pain
Opioid-Sparing Protocol Comparing With Opioid-based Protocol After Bilateral Total Knee Arthroplasty
The concern for the opioid use in the total knee arthroplasty continues to rise in recent decades. Historically, the total knee arthroplasty consumed high doses opioids in the postoperative periods.
- Conditions
- Knee Replacement, Postoperative Pain, Opioid Use
- Trial name
- NCT04314505
- Testing
- Opioid-Sparing Protocol, Opioid-Based Patient Controlled Analgesia
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Arthropathy of Knee Joint
Comparison of Computer-Assisted Navigation and Conventional Instrumentation for Bilateral Total Knee Arthroplasty
To compare the functional outcomes of Computer-Assisted Navigation (CAS) and Conventional Instrumentation TKA at the 8-year follow-up.
- Trial name
- NCT03668756
- Testing
- Computer-Assisted Navigation TKA
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Chang Gung Memorial Hospital
Total Knee Arthroplasty
Comparison Of Outcomes After Knee Arthroplasty Using Posterior-Substituting Versus Cruciate-Retaining Prostheses
Total knee replacement is used in the treatment of patients with knee arthritis, rheumatoid arthritis and other knee disorders. Today, there are basically two designs; It cuts the posterior cruciate ligament (PS) and protects the…
- Trial name
- NCT06170931
- Testing
- posterior cruciate ligament-retaining prostheses, posterior cruciate ligament-substituting prostheses
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Bezmialem Vakif University
Pain, Postoperative, Total Knee Replacement
Postoperative Pain and Blood Loss of Non-use Compared to Partial-use of a Tourniquet in Bilateral Total Knee Replacement
Postoperative pain and blood loss of non-use compared to partial-use of a tourniquet in bilateral total knee replacement: A Randomized- Control Trial This study aimed to compare the effects of non-use (NTU) and partial-use…
- Conditions
- Pain, Postoperative, Total Knee Replacement, Tourniquet
- Trial name
- TKA (NCT06815445)
- Testing
- None tourniquet
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand