Clinical trials: Bile Acid Diarrhea
Cancer
The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms"
The aim of the study is to identify how often gastrointestinal problems interfere with quality of life as a result of treatment for cancer with chemotherapy.
- Trial name
- FOCCUS (NCT02121626)
- Where
- United Kingdom
- Volunteers
- 248 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Bile Acid Malabsorption, Bile Acid Diarrhea
Probiotic in Patients With Bile Acid Malabsorption/Diarrhea
The purpose of this study is to assess effect of the DSF probiotic on fecal bile acid levels in patients with BAM.
- Trial name
- NCT06609148
- Testing
- De Simone formulation probiotic
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Colitis Ulcerosa, Colitis Ulcerative
Magnesium in Gastrointestinal Disease
Individuals with gastrointestinal diseases - such as Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhoea - are at increased risk of magnesium deficiency.
- Conditions
- Colitis Ulcerosa, Colitis Ulcerative, Crohns Disease, Morbus Crohn
- Trial name
- MAGIC (NCT07338565)
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Irritable Bowel Syndrome With Diarrhea
Eluxadoline Bile Acid Malabsorption (BAM) Study
This study will evaluate the possibility of a differential effect of eluxadoline on altered bowel function in Irritable Bowel Syndrome with Diarrhea (IBS-D) participants with and without evidence of Bile Acid Malabsorption (BAM).
- Trial name
- NCT03441581
- Testing
- Eluxadoline
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Allergan
Colon Cancer
Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorption and Small Intestinal Bacterial Overgrowth Using a Novel Sampling Device
The goal of this clinical research study is to learn about gastrointestinal symptoms in participants who have undergone SC or RC and their impact on the quality of life of these participants.
- Trial name
- NCT06927011
- Testing
- Capscan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Bowel Diseases
The Role of Faecal Bile Acids in the Management of Bile Acid Diarrhoea
Bile acid malabsorption (BAM), a common cause of diarrhoea, affects 1 million people in the UK, but is often misdiagnosed as irritable bowel syndrome or goes unrecognised in patients with inflammatory bowel disease.
- Trial name
- NCT02848040
- Testing
- IDK Bile Acids
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Irritable Bowel Syndrome-bile Acid Diarrhea
A Study of Hemp Hull WFI for IBS Diarrhea
The purpose of this study is the effect of a study bar, which contains 15 grams of insoluble dietary fiber total sourced from Hemp hulls, on intestinal permeability in irritable bowel syndrome (IBS)-bile acid diarrhea individuals.
- Trial name
- NCT06028035
- Testing
- BB01
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Colon Adenocarcinoma, Diarrhea
The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon
Many patients suffer from chronic diarrhoea after surgical treatment for cancer in the right side of the colon. The investigators' main hypothesis is that colon cancer patients with chronic diarrhoea have a higher risk of bile…
- Trial name
- NCT04003181
- Testing
- Antibiotics, Bile Acid Binder
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Chronic Diarrhea, Irritable Bowel Syndrome With Diarrhea
Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)
This single-center, randomized, double-blind, placebo-controlled study is designed to compare effects of aldafermin, (NGM282), 1 mg, and placebo given daily by subcutaneous injection on bowel functions and hepatic synthesis and…
- Conditions
- Chronic Diarrhea, Irritable Bowel Syndrome With Diarrhea, Bile Acid Malabsorption, Bile Acid Diarrhea
- Trial name
- NCT05130047
- Testing
- Aldafermin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michael Camilleri, MD
Bile Acid Malabsorption, Bile Acid Diarrhea
Serum Metabolics-based Method for Diagnosing Bile Acid Diarrhoea
Bile acid diarrhoea (BAD) is a common yet under-diagnosed and under-recognised disease. The primary symptoms are watery diarrhoea with high frequency of unpredictable bowel movements,urgency and faecal incontinence making BAD a…
- Trial name
- NCT06548009
- Testing
- Metabolomics and other blood samples
- Where
- 3 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Bile Acid Diarrhea, Bile Acid Malabsorption
Treatment of Bile Acid Diarrhoea With Atorvastatin
Bile acid diarrhoea (BAD) is a socially debilitating disease with stomach pain, high stool frequency, urgency, and faecal incontinence as the main symptoms. Studies estimate that 1-2% of the population suffers from the disease.
- Trial name
- BASTA (NCT07042165)
- Testing
- Atorvastatin
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Asger Lund, MD
Diarrhea Predominant Irritable Bowel Syndrome
Ability of Mayo Clinic High-performance Liquid Chromatography (HPLC) Method to Measure Fecal Bile Acids
The investigators' hypothesis is that therapy with Colesevelam, reduces fecal bile acid excretion in patients with Irritable Bowel Syndrome (IBS)-diarrhea with prior evidence of increased fecal 48 hour total bile acid excretion.
- Trial name
- NCT02111603
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Bile Acid Malabsorption, Chronic Diarrhea
Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea
Bile acid diarrhoea is a chronic disease that impairs quality of life. One in 100 has the condition and many suffer from the disease without knowing.
- Trial name
- SINBAD (NCT03876717)
- Testing
- Colesevelam Hydrochloride
- Where
- 4 sites in Denmark
- Volunteers
- 255 people
- Sponsor
- Lars Kristian Munck
Fecal Incontinence, Bile Acid Malabsorption
A Study of Colesevelam in Fecal Incontinence
Compare the effects of a combination of colesevelam and clonidine to placebo on bowel symptoms in patients with urge or combined type of FI.
- Trial name
- NCT02628626
- Testing
- Colesevelam, Clonidine
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic
Bile Acid Malabsorption
Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea
This study aims to validate a possible diagnostic test for bile acid diarrhoea prospectively compared to the SeHCAT scintigraphy. Fasting participants are given a standard meal and 1,250 mg chenodeoxycholic acid.
- Trial name
- VABAD (NCT03059537)
- Testing
- Oral chenodeoxycholic acid stimulation
- Where
- 5 sites in Denmark
- Volunteers
- 71 people
- Sponsor
- Lars Kristian Munck
Primary Bile Acid Diarrhea
To Assess Safety, Tolerability and Efficacy of LJN452 in Patients With Primary Bile Acid Diarrhea.
The purpose of this study is to determine whether LJN452 improves the symptoms of bile acid diarrhea and to assess its safety and tolerability profile in patients with primary bile acid diarrhea (pBAD) to guide decision-making…
- Trial name
- NCT02713243
- Testing
- LJN452
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Primary Bile Acid Malabsorption, Secondary Bile Acid Malabsorption
Obeticholic Acid in Bile Acid Diarrhoea
The investigators propose to develop studies of obeticholic acid (OCA) in patients with bile acid diarrhoea. OCA is a semisynthetic bile acid, also known as 6αethylchenodeoxycholic acid or INT747,and is a potent farnesoid X…
- Conditions
- Primary Bile Acid Malabsorption, Secondary Bile Acid Malabsorption, Chronic Diarrhoea
- Trial name
- OBADIAH1 (NCT01585025)
- Testing
- Obeticholic acid
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College Healthcare NHS Trust
Chronic Diarrhea, Irritable Bowel Syndrome With Diarrhea
Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption
To compare with a randomized trial (n=15 per treatment group), effects of colesevelam and placebo treatment, on colonic transit, bowel functions, permeability and tight junction expression in rectosigmoid mucosa of IBS-D with…
- Conditions
- Chronic Diarrhea, Irritable Bowel Syndrome With Diarrhea, Bile Acid Malabsorption
- Trial name
- NCT03270085
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Bile Acid Malabsorption
Double-blind, Randomised Study of A3384 in BAM/BAD
The purpose of this trial is to determine the efficacy and safety of A3384 administered to patients with Bile Acid Malabsorption (BAM)/Bile Acid Diarrhoea (BAD).
- Trial name
- NCT02078856
- Testing
- A3384
- Where
- 3 sites in Sweden, United Kingdom
- Volunteers
- 19 people
- Sponsor
- Albireo