Clinical trials: Bile Duct Disease
Cholangiocarcinoma, Bile Duct Obstruction
Endoscopic Biliary RFA of Malignant Bile Duct Obstruction
Endoscopic radiofrequency ablation (RFA) is a new palliation therapy for malignant bile duct obstruction. It delivers a high amount of thermal energy to target tissue and may prolong the duration of stent patency.
- Trial name
- NCT02582541
- Testing
- SEMS alone, SEMS plus radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Pruritus
Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)
This is a 2-part study in PBC participants with cholestatic pruritus and will evaluate the efficacy, safety and impact on health-related quality of life of linerixibat compared with placebo.
- Trial name
- NCT04950127
- Testing
- Linerixibat
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 238 people
- Sponsor
- GlaxoSmithKline
Choledocholithiasis, Common Bile Duct Neoplasms
Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones
Karl Storz GmbH (Gesellschaft mit beschränkter Haftung) company developed a cholangioscopic device, which is designed to give a better flexibility to the cholangioscopy tip in order to enable optimal diagnostic and therapeutic…
- Conditions
- Choledocholithiasis, Common Bile Duct Neoplasms, Cholestasis
- Trial name
- SAC (NCT01683240)
- Testing
- cholangioscopy (Frimberger)
- Where
- 5 sites in Germany
- Volunteers
- 59 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Liver Disease, Cholestasis
Gabapentin to Treat Itch in Patients With Liver Disease
In this study, the effect of the medication gabapentin to treat itching secondary to liver disease is being studied. There are some funds to cover travel expenses for patients who are not from New York (NY).
- Conditions
- Liver Disease, Cholestasis, Cirrhosis, Pruritus
- Trial name
- NCT00058890
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cholestasis
Cholestasis in Extreme Low Birth Weight Infants (ELBW)
Parenteral nutrition associated liver disease (PNALD) in preterm neonates is characterized by early occurrence of intrahepatic cholestasis (parenteral nutrition associated cholestasis (PNAC).
- Trial name
- NCT01164878
- Volunteers
- 122 people
- Sponsor
- Medical University of Vienna
Advanced Adult Hepatocellular Carcinoma, Localized Non-Resectable Adult Liver Carcinoma
MK2206 in Treating Patients With Advanced Refractory Biliary Cancer That Cannot Be Removed by Surgery
This phase II trial is studying how well MD2206 works in treating patients with advanced refractory biliary cancer that cannot be removed by surgery.
- Conditions
- Advanced Adult Hepatocellular Carcinoma, Localized Non-Resectable Adult Liver Carcinoma, Recurrent Adult Liver Carcinoma, Recurrent Gallbladder Carcinoma
- Trial name
- NCT01425879
- Testing
- Akt Inhibitor MK2206, Diagnostic Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 8 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Pancreatic Cancer
Radiofrequency Probe for Management of Unresectable Bile Duct and Pancreatic Cancer
The purpose of this study is to determine whether the use of an FDA approved endoscopic bipolar catheter (EndoHPB) will ablate tissue in malignant tumors within the pancreatic ducts.
- Trial name
- EndoHPB (NCT02042859)
- Testing
- Endoscopic Bipolar RadioFrequency Probe used to remove tumors in bile duct to manage Pancreatic Cancer
- Volunteers
- 40 people
- Sponsor
- Ochsner Health System
Liver and Intrahepatic Bile Duct Disorder
Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery
This phase III trial studies how well thoracic epidural analgesia or four-quadrant transversus abdominus plane block works in reducing pain in patients undergoing liver surgery.
- Trial name
- NCT03214510
- Testing
- Bupivacaine, Fentanyl, Hydromorphone Hydrochloride
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- M.D. Anderson Cancer Center
Bile Duct Diseases
Angled-tip vs. Straight-tip Guidewire in Biliary Cannulation
The investigators aim is to compare outcomes between an angled-tip guidewire and a straight-tip guidewire in cannulation of the common bile duct during ERCP. This is a randomized, controlled, single-blinded study.
- Trial name
- NCT05600270
- Testing
- Angled guidewire, Straight guidewire
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Neev Mehta
Choledocholithiasis
Role of EUS in High Risk of Choledocholithiasis
The aim of this study is to demonstrate that patients with high risk of choledocholithiasis who undergo ERCP only for patients with choledocholith in the EUS examination[EUS-ERCP group] have less negative outcomes (including…
- Trial name
- NCT03250286
- Testing
- EUS, ERCP
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Woo Hyun Paik
Cholangiojejunostomy, Cholelithiasis
Clinical Application of Cholangiojejunostomy in the Surgical Treatment of Cholelithiasis With Moderate Dilatation of Common Bile Duct
This study evaluates the clinical application of cholangiojejunostomy in the surgical treatment of cholelithiasis with Moderate dilatation of common bile duct.
- Trial name
- NCT02915770
- Testing
- cholangiojejunostomy, hepatectomy, T-tube
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Southwest Hospital, China
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Gemcitabine With or Without Cisplatin in Treating Patients With Unresectable Locally Advanced or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- ABC-02 (NCT00262769)
- Testing
- cisplatin, gemcitabine hydrochloride
- Where
- 25 sites in United Kingdom
- Volunteers
- 324 people
- Sponsor
- University College, London
Progressive Familial Intrahepatic Cholestasis (PFIC)
A Placebo-controlled Study of Maralixibat (SHP625) in Pediatric Subjects With Progressive Familial Intrahepatic Cholestasis (PFIC)
The purpose of this study is to determine if the investigational treatment (maralixibat) is safe and effective in pediatric participants with Progressive Familial Intrahepatic Cholestasis (PFIC).
- Trial name
- NCT03353454
- Testing
- Maralixibat
- Sponsor
- Mirum Pharmaceuticals, Inc.
Bile Duct Obstruction
Flushing of Internalized Percutaneous Transhepatic Biliary Drainage Catheters
Percutaneous transhepatic biliary drainage (PTBD) is a drainage method for biliary obstruction. Patients with a PTBD catheter often need multiple re-interventions because of symptoms of catheter obstruction such as pain…
- Trial name
- FLUSH (NCT04915703)
- Testing
- Flushing of PTBD catheter
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Erasmus Medical Center
Primary Biliary Cholangitis (PBC)
Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis: a Real World Study
An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Fenofibrate in Combination with Ursodeoxycholic Acid in Subjects with Primary Biliary Cholangitis (PBC)
- Trial name
- NCT06755541
- Testing
- Fenofibrate in Combination With Ursodeoxycholic Acid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Biliary Atresia, Prognosis
Preoperative Serum FGF19 in the Prognosis of Biliary Atresia
To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.
- Trial name
- NCT05848310
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Congenital Choledochal Cyst, Pediatric Surgery
Open vs. Laparoscopic Surgery for Pediatric Choledochal Cyst
This is a retrospective cohort study designed to compare the outcomes of open surgery versus laparoscopic surgery in pediatric patients diagnosed with congenital choledochal cyst (CCC).
- Conditions
- Congenital Choledochal Cyst, Pediatric Surgery, Surgical Outcomes, Open Surgery
- Trial name
- NCT06716762
- Testing
- Open Surgery, Laparoscopic Surgery
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- In-Jin Jang
Cholangitis
Short-course Antibiotics vs Standard Course Antibiotics in Patients With Cholangitis
The goal of this multicentre randomized controlled trial is to investigate if a very short-course of antibiotics (1 day) for cholangitis after adequate drainage is non-inferior with respect to clinical cure in comparison with a…
- Trial name
- COBRA (NCT05750966)
- Testing
- cefrtriaxone, gentamicin, cefuroxim, ciprofloxin or other antibiotics according to local guideline (24 hours), cefrtriaxone, gentamicin, cefuroxim, ciprofloxin or other antibiotics according to local guideline (4 to 7 days)
- Where
- 31 sites in Netherlands
- Volunteers
- 410 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parenteral Nutrition Associated Liver Disease
Omegaven Expanded Access Protocol
Omegaven is an intravenous fat emulsion (IFE) comprised of omega-3 fatty acids derived from fish oil. It will be used in an open label compassionate use treatment protocol, as an alternative to soybean oil (omega-6), as the sole…
- Trial name
- NCT02121769
- Testing
- Omegaven
- Where
- United States
- Sponsor
- St. Luke's Health System, Boise, Idaho
Biliary Stones, Cholangiocarcinoma, Intrahepatic
Percutaneous Cholangiopancreatoscopy Registry
The Percutaneous Cholangiopancreatoscopy (PCPS) registry is an observational, multicentric, prospective, and retrospective registry of patients undergoing the percutaneous cholangiopancreatoscopy procedure at sites across the…
- Conditions
- Biliary Stones, Cholangiocarcinoma, Intrahepatic, Biliary Stricture, Cholelithiasis
- Trial name
- NCT05210322
- Testing
- Percutaneous cholangiopancreatoscopy
- Where
- United States
- Volunteers
- 679 people
- Sponsor
- Johns Hopkins University
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