Clinical trials: Biofilm
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Periodontitis, Aggressive, Periodontal Diseases
Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.
The first step in the management of periodontal disease involves the non-surgical removal of the soft and hard bacterial deposits at all supra- and sub-gingival sites, especially into deep pockets, which can be carried on with…
- Conditions
- Periodontitis, Aggressive, Periodontal Diseases, Periodontitis
- Trial name
- ERISRP (NCT05112471)
- Testing
- Airflow, Perioflow and Erythritol powder and ultrasonic debridement, Ultrasonic debridement and curettes
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Dental Plaque
Antimicrobial Photodynamic Therapy With Erythrosine and Blue Light on Dental Biofilm Bacteria
The objective of this study is to investigate the effect of Antimicrobial Photodynamic Therapy mediated by Erythrosine and blue LED in the reduction of bacteria in dental biofilm.
- Trial name
- NCT05805761
- Testing
- Conventional Treatment, Antimicrobial Photodynamic Therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Peri-Implant Health, Implant Complication
Influence of Zirconia Abutments on Peri-Implant Tissues in Single-Tooth Restorations
Objectives: To compare the influence of pre-fabricated titanium abutments and customized milled zirconia abutments on implant biocompatibility and the peri-implant region, as well as on radiographic bone loss and oral…
- Conditions
- Peri-Implant Health, Implant Complication, Prosthesis and Implants
- Trial name
- NCT07456163
- Testing
- Pre-fabricated standardized titanium abutments, Customized anatomical zirconia abutments
- Where
- Brazil
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontitis
Efficacy of Guided Biofilm Therapy (GBT) for Treatment of Deep Periodontal Pockets.
the aim of the study is to evaluate the efficacy of guided biofilm therapy (GBT) for treatment of deep periodontal pockets. the objectives are 1- To compare the change in the clinical periodontal parameters and microbiological…
- Trial name
- NCT06319261
- Testing
- guided biofilm therapy, root surface debridement
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Dental Caries, Dental Plaque
Study of the Composition of Dental Plaque
This study will examine the composition of dental plaque-a naturally occurring substance that sticks to the teeth and can cause tooth decay and gum disease.
- Conditions
- Dental Caries, Dental Plaque, Periodontal Disease
- Trial name
- NCT00001726
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Urinary Incontinence
A Prospective Analysis of Biofilm in Urinary Catheters Study
To analyze biofilm obtained from at least 10 Subjects who have an indwelling catheter. A 30cc urine sample would also be collected from the same subject, and analyzed.
- Trial name
- NCT01987336
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Black Staining
Comparison of Erythritol Air-Polishing and Conventional Polishing Following Ultrasonic Scaling on the Relapse of Chromogenic Tooth Staining in Children
The goal of this randomized clinical trial is to compare the effect of erythritol air-polishing and conventional polishing following ultrasonic scaling on the relapse of chromogenic tooth staining in children aged 4-13 years…
- Trial name
- NCT07730658
- Testing
- Guided Biofilm Therapy with erythritol, Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis, Adult
Protozoans in Biofilm From Patients With Periodontitis
The buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients.
- Trial name
- Paro-Proto (NCT03240666)
- Testing
- non applicable
- Where
- France
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Dental Diseases
Investigation of Bacterial Adhesion and Bactericide Effect ex Vivo on Different Implant Restoration Materials
Investigation of bacterial adhesion and bactericide effect ex vivo on different implant restoration materials
- Trial name
- NCT04657757
- Testing
- Intraoral apparatus
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Dental Plaque
Efficacy of a Triclosan Formulation to Control the Initial Subgingival Biofilm Formation
The aim of the study is to compare the effect of a suspension containing Triclosan in dynamic of the subgingival biofilm formation versus a Placebo suspension.
- Trial name
- NCT02192060
- Testing
- Test - Using of a suspension containing Triclosan, Control - Using of a suspension without Triclosan
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Dental Caries, Periodontitis
Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
- Conditions
- Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission
- Trial name
- NCT07674888
- Testing
- Professional Dental Plaque Disruption
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Severe Periodontitis, Acute Inflammatory Response
IFI16 is a Periodontitis Modulating Protein
To characterize the expression of Interferon gamma inducible protein 16 (IFI16) and Absent in melanoma 2 (AIM2) in gingival tissues in an inflammatory response using an acrylic mouthguard (also referred to as a stent) induced…
- Trial name
- IFI (NCT03513497)
- Testing
- Customized acrylic mouthguard
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Class I Dental Caries
Clinical Evaluation of Bioactive Restorative Materials
The objectives of this study are to evaluate and compare the biofilm inhibition and re-mineralizing potential at tooth restoration interface and their 2-year clinical performance in class I cavities.The patients will be selected…
- Trial name
- NCT07003360
- Testing
- application of beautiful blukfill II shofu composite, application of Ivoclar vivadent bulkfill composite, application of Predicta bulk fill composite
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Breast Cancer, Gingivitis
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer
Objective: To evaluate the impact of chemotherapy on periodontal conditions, hematology, and salivary flow in patients with breast cancer and gingivitis, after basic periodontal therapy (BPT).
- Conditions
- Breast Cancer, Gingivitis, Periodontal
- Trial name
- BREASTCANCER (NCT06212908)
- Testing
- Basic Periodontal Therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peri-implant Mucositis
Non-surgical Treatment of Peri-implant Mucositis: FMUD vs FMUD and Air-Flow Master Piezon®
The aim of the present study is to evaluate the adjunctive effect of glycine-powder air-polishing (GPAP) to full-mouth ultrasonic debridement (Fm-UD) in the treatment of peri-implant mucositis, and to determine the predictive…
- Trial name
- NCT05801315
- Testing
- Glycine powder air polishing, Full mouth ultrasonic debridement
- Where
- Italy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Siena
Microbiology, Alveolar Ridge Preservation
Microbiome Analysis of Dental Biofilm on High-Density Polytetrafluoroethylene Membranes Used in Socket Preservation
The goal of this clinical trial is to evaluate how different types of high-density polytetrafluoroethylene (d-PTFE) membranes impact dental biofilm accumulation and composition in patients undergoing socket preservation following…
- Conditions
- Microbiology, Alveolar Ridge Preservation, Infections, Bacterial
- Trial name
- MADBioS (NCT06694844)
- Testing
- Socket preservation with M1, Socket preservation with M2
- Where
- Croatia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Marija Čandrlić
Self Cleaning
Evaluation of the Effectiveness of Fibrous Foods, Sugar-free Gomes and Rolly Brush® in the Dental Biofilm Removal
The objective of this study was to evaluate the efficacy of three methods for removal of dental biofilm when compared to dental toothbrushing control.
- Trial name
- NCT03601585
- Testing
- Comparison of dental biofilm removal.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Dental Plaque
Effect of Provisional-Crown Surface Coating on Biofilm Formation
Auto polymerizing poly methyl methacrylate (PMMA), and light initiated resin modified PMMAs, are commonly used for fabricating provisional restorations (PRs) during prosthetic treatment 1.
- Trial name
- NCT00254345
- Testing
- coating a dental restoration material ,polymethylmethacrylate, with liquid polish resin
- Where
- Israel
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Healthy
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and…
- Trial name
- NCT00098267
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)