Clinical trials: Biofilm
Dental Plaque, Dental Caries
Probiotic Treatment of Orthodontic Patients
The purpose of this study is to examine the effect of treatment with a lozenge containing the probiotic strain S. salivarius M18 on the formation, composition and virulence of dental plaque and in healthy orthodontic patients…
- Trial name
- NCT06751979
- Testing
- Probiotic treatment
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Wound
Evaluating Wound Healing With Next Science Gel & Wash.
This is a 12-week, single-site, open-label prospective study in adult with a chronic wound diagnosis. Subjects will be randomized in equal numbers to either the control treatment arm, antimicrobial control treatment arm, or Next…
- Trial name
- NCT03738579
- Testing
- Next Science Group, Control Group, Antibacterial Control Group
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Next Science TM
Dental Caries, Oral Health
Effect of Probiotics Containing Yogurts on the Composition of Biofilms in Patients Under Orthodontic Treatment
Aim: To assess in vivo if the intake of yogurt containing Bifidobacterium animalis ssp. lactis DN- 1173010 probiotic for a period of 2 weeks affects the salivary levels or biofilms of mutans streptococci and the lactobacilli of…
- Trial name
- NCT01657539
- Testing
- Yogurt containing probiotics
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Right-sided Colon Cancer, Right-sided Colon Adenoma
Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma (MEFO-trial)
Clinical studies have shown that patients with right-sided colon cancer have reduced progression-free and overall survival compared to patients with left-sided colon cancer.
- Trial name
- MEFO (NCT04312360)
- Testing
- therapeutic endoscopy with metronidazole and fosfomycin disodium
- Where
- 2 sites in Denmark
- Volunteers
- 28 people
- Sponsor
- Zealand University Hospital
Chronic Gingivitis, Chronic Gingivitis, Plaque Induced
Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health
This study evaluates the addition of a mouth rinse containing sea salt, xylitol and lysozyme to standardized oral health practices on biofilm formation and gingival health in a group of young adults.
- Trial name
- NCT03329105
- Testing
- Sea Salt Mouth Rinse, Standardized Oral Health Practices
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Orthodontic Appliances, Removable, Dental Plaque
Cleaning Methods for Clear Aligners
The goal of this clinical trial is to learn which cleaning method best removes bacteria from clear plastic aligners. Clear aligners are removable orthodontic trays worn to straighten teeth.
- Conditions
- Orthodontic Appliances, Removable, Dental Plaque, Biofilms, Disinfection
- Trial name
- NCT07610603
- Testing
- Toothbrushing of clear aligner with water, Chlorhexidine gluconate 0.2% oral rinse, Effervescent aligner cleaning tablet
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Urinary Tract Infection(UTI)
E. Coli for Prevention of Catheter UTI in SCI Patients
The overall goal of this project is to develop a new approach for the prevention of urinary tract infection (UTI) in persons who rely on indwelling catheters for bladder drainage.
- Trial name
- NCT00458471
- Testing
- Insertion of a urinary catheter coated with benign E. coli
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Severe Periodontitis, Acute Inflammatory Response
IFI16 is a Periodontitis Modulating Protein
To characterize the expression of Interferon gamma inducible protein 16 (IFI16) and Absent in melanoma 2 (AIM2) in gingival tissues in an inflammatory response using an acrylic mouthguard (also referred to as a stent) induced…
- Trial name
- IFI (NCT03513497)
- Testing
- Customized acrylic mouthguard
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mandibular Prosthesis User
Assessment of the Impact of Probiotics on Biofilm Formation on Removable Acrylic Dentures
The aim of this study is to evaluate the effect of PIP toothbrush cleaner® on the microbial composition and Candida albicans colonization of denture biofilm formation.
- Trial name
- NCT02736994
- Testing
- PIP toothbrush cleaner® (Chrisal, Lommel, Belgium)., Corega Tabs Anti-bacteria®, Water
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Periodontitis, Periodontitis (Stage 3)
Effect of Guided Biofilm Therapy in Patients With Stage 3 Periodontitis
This randomized interventional study aims to compare the clinical and biochemical effects of conventional non-surgical periodontal therapy (NSPT), adjunctive diode laser therapy, and guided biofilm therapy (GBT) in patients with…
- Trial name
- NCT07788937
- Testing
- Non-Surgical Periodontal Therapy, Diode Laser Therapy, Guided Biofilm Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Intubation, Expected Duration of Ventilation > 48h
Evaluation of a Closed Suction System to Remove Secretions From the Endotracheal Tube
Cleaning the endotracheal tube with a specifically designed device results in lower amount of secretions at extubation, assessed by micro CT scan
- Trial name
- NCT01912105
- Testing
- Airway medix closed suction system, standard closed suctioning systems
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Prosthetic Joint Infection
Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation
Study Type Prospective, single-arm, open-label, multicenter (3 to 5 sites), interventional trial. Primary Study Objective The objective of the study is to determine the safety profile of local antibiotic irrigation for the…
- Trial name
- NCT03721328
- Testing
- vancomycin hydrochloride and tobramycin sulfate
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Osteal Therapeutics, Inc.
Thermal Burn, Wound
Biofilm Infection in Adults and Children Burn Injury
The objective of the study is to analyze the different implications (such as graft loss and conversion of indeterminate depth burns) of biofilm infections in burn patients.
- Trial name
- NCT03248154
- Testing
- Procellera
- Where
- 4 sites in United States
- Sponsor
- Gayle Gordillo
Dental Plaque, Oral Health
Bacterial Arrangement on the Teeth
Background: Dental plaque is a coating of bacteria on the teeth. It contributes to poor dental health and diseases such as gingivitis, cavities and periodontal disease.
- Conditions
- Dental Plaque, Oral Health, Periodontal Disease and Caries, Periodontal Disease
- Trial name
- NCT01712672
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Gingival Hyperpigmentation, Oral Pigmentation
Comparison of Er-YAG Laser, Air Polishing, and Surgical Excision for Gingival Hyperpigmentation
This randomized controlled clinical trial aimed to compare the effectiveness of different treatment approaches for physiologic gingival hyperpigmentation.
- Trial name
- APGH (NCT07672587)
- Testing
- Er:YAG Laser Therapy, Air Polishing with Erythritol Powder, Air Polishing with Sodium Bicarbonate Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Inflammatory Response, Microbial Colonization
Microbial Adhesion and Biofilm Formation on Denture Base Materials
Polymethylmethacrylate (PMMA) has been the material of choice for fabricating complete dentures for more than 80 years now.(1,2) As a material it is easy to handle and can be easily repaired and polished.
- Conditions
- Inflammatory Response, Microbial Colonization, Denture Stomatitis
- Trial name
- NCT06395116
- Testing
- Denture base material
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Prosthetic Joint Infection, Staphylococcus Aureus
Evaluation of the Antibiofilmogramme Test During Orthopaedic Device-Related Infection
This is an observational study that does not change routine care. The primary objective of this study is to investigate the correlation between the administration of an antibiotherapy able to prevent biofilm formation according…
- Conditions
- Prosthetic Joint Infection, Staphylococcus Aureus, Biofilm
- Trial name
- BJIBiofilm (NCT03263832)
- Testing
- Antibiofilmogramme
- Where
- France
- Volunteers
- 45 people
- Sponsor
- BioFilm Control
Rhinosinusitis Chronic, Microbiome
Impact of Symbiofilm On Nasal Microbiota
Healsea® chronic is CE marked medical device indicated in adults for the treatment of nasal symptoms of chronic rhinosinusitis. This is an hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extract (0.2%)…
- Trial name
- ISONAM (NCT05015530)
- Testing
- Healsea® Chronic, hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extract
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Lallemand Pharma AG
End-Stage Kidney Disease, Renal Dialysis
The Impact of Different Citrate Concentrations as Locking Solutions on Development of Biofilm and Function of Hemodialysis Catheters
Evidence that supports using certain concentration of trisodium citrate as a locking solution for hemodialysis catheters has not yet been established.
- Conditions
- End-Stage Kidney Disease, Renal Dialysis, Central Venous Catheter, Biofilms
- Trial name
- NCT03683563
- Testing
- 4% sodium citrate, 30% sodium citrate
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Biofilms, Substantivity
Immediate Effect and Substantivity of the Essential Oils Without Alcohol on the Oral Biofilm in Situ
This study aims to evaluate the in situ antibacterial activity of a mouthwash containing essential oils with and without alcohol on undisturbed de novo plaque-like biofilm (PL-biofilm) up to 7 h after its application.
- Conditions
- Biofilms, Substantivity, Oils, Essential
- Trial name
- NCT02946814
- Testing
- essential oils, essential oils without mouthwash, sterile water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela