Clinical trials: Biological Therapy
Colitis, HIV Infections
A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
To determine the oral bioavailability of three dose levels of oral ganciclovir given with and without glutamic acid hydrochloride in patients with cytomegalovirus (CMV) GI disease, and to compare the bioavailability of these…
- Trial name
- NCT00000768
- Testing
- Glutamic acid hydrochloride, Ganciclovir
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, Psychological Trauma
Efficacy of EMDR Therapy, as Compared to Treatment as Usual, in Reducing Clinical Symptoms in People With HIV
People living with HIV may suffer HIV-related psychological trauma. Studies also show that this group is vulnerable to non-HIV-related trauma. Trauma can increase vulnerability to stress and reducing the ability to cope.
- Conditions
- HIV/AIDS, Psychological Trauma, PTSD
- Trial name
- NCT03848858
- Testing
- EMDR plus TAU
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Parc de Salut Mar
Polyarticular Juvenile Rheumatoid Arthritis, Arthritis, Juvenile Idiopathic
Start Time Optimization of Biologics in Polyarticular JIA
STOP-JIA is a PCORI funded prospective observational study which compared the clinical effectiveness and impact on patient reported outcomes of 3 Childhood Arthritis \& Rheumatology Research Alliance (CARRA) consensus derived…
- Trial name
- STOP-JIA (NCT02593006)
- Where
- 55 sites in United States, Canada
- Volunteers
- 400 people
- Sponsor
- Hackensack Meridian Health
Colitis, Ulcerative
BI655130 (SPESOLIMAB) Induction Treatment in Patients With Moderate-to-severe Ulcerative Colitis
This trial has two sequentially enrolling parts with different objectives. The primary objectives of this trial are to prove the concept of clinical activity of BI655130 (SPESOLIMAB) in patients with moderate-to-severely active…
- Trial name
- NCT03482635
- Testing
- Spesolimab
- Where
- 54 sites in United States, Austria and 10 more
- Volunteers
- 98 people
- Sponsor
- Boehringer Ingelheim
Axial Spondyloarthritis (Ankylosing Spondylitis)
Mediterranean Diet and Disease Activity in Axial Spondyloarthritis Receiving Biologic Therapy
This study aims to evaluate the effect of the Mediterranean diet on disease activity, quality of life, inflammation, pain, and treatment response in patients with axial spondyloarthritis (ankylosing spondylitis) who are receiving…
- Trial name
- NCT07170384
- Testing
- Mediterranean Diet, Healthy Eating Advice
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Sinem Kübra Beke
Non-small-cell Lung Cancer (NSCLC) Stage IV
A Phase III Trial of Recombinant Human Apo-2 Ligand for Injection
The trial is to evaluate the efficacy and safety of recombinant human Apo-2 ligand in treating patients with advanced retreated non-small cell lung cancer
- Trial name
- NCT03083743
- Testing
- Recombinant human Apo-2 ligand for Injection
- Where
- China
- Volunteers
- 417 people
- Sponsor
- Shanghai Gebaide Biotechnology Co., Ltd.
Chronic Hepatitis b, Liver Inflammation
Magnesium Isoglycyrrhizinate Followed by Diammonium Glycyrrhizinate and Combined With Entecavir in Chronic Hepatitis B
This study evaluates the addition of glycyrrhizin to entecavir in the treatment of patients with chronic hepatitis B in China. Half of participants will receive magnesium isoglycyrrhizinate followed by oral diammonium…
- Trial name
- MAGIC-101 (NCT03349008)
- Testing
- Entecavir, Magnesium Isoglycyrrhizinate, Diammonium Glycyrrhizinate
- Volunteers
- 480 people
- Sponsor
- Cttq
Infections, Streptococcal
Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment
The aim of the current study is to determine whether ibuprofen, given as immediate or delayed prophylactic antipyretic treatment in a standardized manner, significantly impacts the immune response in children receiving primary…
- Trial name
- NCT01235949
- Testing
- GSK1024850A (SynflorixTM), Infanrix hexa, Infanrix-IPV/Hib
- Where
- 23 sites in Romania
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Prostate Cancer
Comparison of Radiation Therapy Regimens in Treating Patients With Localized Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective for prostate cancer.
- Trial name
- NCT00010244
- Testing
- radiation therapy
- Where
- 19 sites in France
- Volunteers
- 306 people
- Sponsor
- UNICANCER
Breast Cancer
Lapatinib and Radiation Therapy in Treating Patients With Locally Recurrent or Chemotherapy-Refractory Locally Advanced or Metastatic Breast Cancer
RATIONALE: Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00379509
- Testing
- lapatinib ditosylate, TdT-mediated dUTP nick end labeling assay, gene expression analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diabetic Retinopathy
A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment
This study is open to adults with diabetic macular ischemia who have received laser treatment. The main purpose of this study is to find out whether people with diabetic macular ischemia can tolerate a medicine called BI 765128.
- Trial name
- PARTRIDGE (NCT04919499)
- Testing
- BI 765128
- Where
- 25 sites in United States, Australia and 4 more
- Volunteers
- 46 people
- Sponsor
- Boehringer Ingelheim
Rheumatoid Arthritis (RA)
Medical Device for Sustained Remission in Rheumatoid Arthritis Treated With Biological Therapy
This study aims to evaluate a new tool designed to help doctors decide whether it is safe to reduce medication in patients with rheumatoid arthritis (RA) who are in remission.
- Trial name
- REMRABIT-Plus (NCT07678112)
- Testing
- Predictive Model-Guided Decision Strategy
- Where
- 9 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Francisco J. Blanco
Post Traumatic Stress Disorder, Complex Posttraumatic Stress Disorder
Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress
In the last four years alone, residents of Puerto Rico have experienced a slew of natural disasters including Hurricane Maria in 2017, earthquakes in 2019 and 2020, the continued COVID-19 pandemic from 2020-2022, and most…
- Conditions
- Post Traumatic Stress Disorder, Complex Posttraumatic Stress Disorder, Stress, Burn Out
- Trial name
- NCT05701111
- Testing
- Start with the Heart Students, Start with the Heart Teachers, Cue Centered Therapy Counselors
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 80,800 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cancer, Neoplasms
A Phase I Study of the Chimeric Anti-CD40 Monoclonal Antibody ChiLob 7/4 to Treat Advanced Malignancies Refractory to Conventional Anti-cancer Treatment
The Purpose of this study is to evaluate the safety and tolerability, and the biological effects of the chimeric anti-CD40 monoclonal antibody Chi Lob 7/4, given intravenously, weekly for 4 weeks in the treatment of patients with…
- Conditions
- Cancer, Neoplasms, Lymphoma, Non-Hodgkin
- Trial name
- NCT01561911
- Testing
- Chi Lob 7/4 (A chimeric monoclonal antibody)
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- Cancer Research UK
Amyotrophic Lateral Sclerosis
Biological Treatment of Amyotrophic Lateral Sclerosis
The purpose of this study is to test the safety and effectiveness of an autologous bone marrow-derived stem/progenitor cells infusion in the subjects with diagnosed amyotrophic lateral sclerosis.
- Trial name
- NeuStem-ALS (NCT02193893)
- Testing
- Biological: Cell-based therapeutics, Symptomatic treatment of ALS
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Pomeranian Medical University Szczecin
Juvenile Idiopathic Arthritis
Determining Predictors of Safe Discontinuation of Anti-TNF Treatment in JIA
Polyarticular juvenile idiopathic arthritis (Poly JIA) is a form of juvenile arthritis, which is a chronic disease affecting approximately 250,000 people younger than 16 years of age.
- Trial name
- NCT00792233
- Testing
- Withdrawal of anti-TNF therapy
- Where
- 16 sites in United States
- Volunteers
- 137 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Nasal Polyps, Sinusitis
Dupixent Study for Alternate Administration
Investigators will investigate an alternate Dupilumab administration schedule in patients with recurrent chronic rhinosinusitis with nasal polyposis, who have a history of full endoscopic sinus surgery and are on appropriate…
- Conditions
- Nasal Polyps, Sinusitis, Chronic Disease
- Trial name
- NCT06750471
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Women Diagnosed With Infertility
The Effect of the Mediterranean Diet on Fatty Acids in Biological Fluids of Women Undergoing Infertility Treatment
The aim of this study was to examine the effect of the Mediterranean diet, which is accepted as one of the adequate and balanced nutrition models today, as well as serum and follicular fluid fatty acid profile and implantation…
- Trial name
- NCT06559904
- Testing
- Mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Trakya University
Rheumatoid Arthritis, Juvenile Idiopathic Arthritis
Anti-Biopharmaceutical Immunization: Prediction and Analysis of Clinical Relevance to Minimize the Risk of Immunization in Rheumatoid Arthritis Patients or Juvenile Idiopathic Arthritis Patients
One of the main potential causes of these failures of BP therapy response is the development of Anti-drug Anti-body (ADAb) in some patients.
- Trial name
- ABI-RA (NCT02116504)
- Testing
- Sampling of blood
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease, Inflammatory Bowel Diseases
COmbinAtion Therapy of dieT With biologicalS for Crohn's Disease: the OATS Study
This study is a randomised open label study, comparing the FIT diet with standard diet in patients with Crohn's disease treated with biologic therapy.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Diet, Healthy
- Trial name
- OATS (NCT04946448)
- Testing
- FIT diet
- Where
- Belgium
- Volunteers
- 144 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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