Clinical trials: Biopsy, Fine-Needle
Pancreatic Cancer
Evaluation of Multiple Needle Use in EUS-FNA for Pancreatic Cancer
The aim of this study is to evaluate if the early change of needle during EUS-FNA for suspected pancreatic cancer allows an earlier preliminary cytological diagnosis of neoplasia.
- Trial name
- EMUNE-07 (NCT00548626)
- Testing
- Single needle, Multiple needle
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Chicago
Pancreas Disease, Liver Diseases
Motorized Fine Needle Biopsy vs Standard Needles
Recent improvements in punctures techniques and needles now allow for the collection of high-quality specimens comparable to core needle biopsy.
- Trial name
- NCT06298604
- Testing
- EUS-guided standard fine needle biopsy, EUS-guided motorized fine needle biopsy
- Where
- Ecuador
- Volunteers
- 60 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Thyroid Gland Nodule
Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules
This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules.
- Trial name
- NCT03676647
- Testing
- Diagnostic DNA Methylation Signature
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Pancreatic Tumor, Fine Needle Aspiration
Comparison of Two Needles (ProCore vs EchoTip) for the Diagnosis of Pancreatic Solid Mass Under EUS
The negative predictive value of fine needle aspiration under ultrasound endoscopy (EUS) for the diagnostic of solid pancreatic masses is 70% on average in the current literature with 22 gauge needles.
- Conditions
- Pancreatic Tumor, Fine Needle Aspiration, Endoscopic Ultrasonography
- Trial name
- PICORE (NCT01479803)
- Testing
- Puncture with fine needle aspiration under endoscopic ultrasonographic control
- Where
- France
- Volunteers
- 80 people
- Sponsor
- VANBIERVLIET
Solid Pancreatic Tumor
Endoscopic Ultrasound (EUS)-Guided Fine Needle Aspiration (FNA) With Rapid On-site Evaluation (ROSE) of Cytopathology vs. EUS-guided Fine Needle Biopsy (FNB) Alone in the Diagnosis of Pancreatic Solid Lesions
Currently, the best way to evaluate pancreatic masses is through endoscopic-guided needle sampling of the mass to determine the diagnosis by looking at the acquired tissue under a microscope.
- Trial name
- NCT03435588
- Testing
- EUS, FNA with ROSE, FNB alone
- Where
- 6 sites in Canada
- Volunteers
- 235 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Klatskin Tumor, Cholangiocarcinoma
Diagnostic Efficacy of EUS-FNA/B Versus ERCP With or Without POCS-TB in Patients With Suspected Hilar Cholangiocarcinoma
This is an observational study with a prospective cohort design. This study enrolled patients with suspected hilar cholangiocarcinoma on imaging.
- Conditions
- Klatskin Tumor, Cholangiocarcinoma, Biopsy, Fine-Needle, Endoscopic Retrograde Cholangiopancreatography
- Trial name
- NCT05993429
- Testing
- The sampling method selected in patients with suspected hilar cholangiocarcinoma
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qilu Hospital of Shandong University
Autoimmune Pancreatitis
Diagnostic Yield of FNA Needle and FNB Needle for Autoimmune Pancreatitis
The aim of this study is to compare the diagnostic accuracy of two EUS-guided tissue acquisition devices; the 19G Echotip Ultra Fine Needle Aspiration (FNA) device and the 20G Echotip ProCore Fine Needle Biopsy (FNB) device for…
- Trial name
- NCT03753815
- Testing
- 19G FNA needle, 20G FNB needle
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Peking Union Medical College Hospital
Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer
Studies on Tumors of the Thyroid
Participants in this study will be patients diagnosed with or suspected to have a thyroid nodule or thyroid cancer. The main purpose of this study is to further understand the methods for the diagnosis and treatment of thyroid…
- Conditions
- Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer, Follicular Thyroid Cancer, Thyroid Cancer
- Trial name
- NCT00001160
- Testing
- 68-Gallium Dotatate
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatic Masses
RCT Comparing Accuracy Among Franseen, Forward-bevel Westcott, and Fork-tip EUS-FNB Needle in Diagnosis of Solid Pancreatic Lesions
Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) is a well-established technique for pancreatic tissue acquisition, offering a high diagnostic accuracy ranging from 78% to 95%, along with a favorable safety profile.
- Trial name
- NCT07032974
- Testing
- Franseen, Forward-bevel, Fork-tip
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Mahidol University
GI Lesions
Endoscopic Ultrasound (EUS) Fine Needle Biopsy (FNB) Submucosal Nodule
The purpose of this study is to compare the diagnostic accuracy of a novel endoscopic ultrasound (EUS) biopsy needle to the current standard EUS needle.
- Trial name
- NCT03011229
- Testing
- Pro Core Needle, medtronic Sharkcore Needle
- Where
- United States
- Sponsor
- Duke University
Pancreatic Neoplasm
Comparing Biopsy Needles for Endoscopic Ultrasound Guided Samples for Pancreatic Masses
This is a randomized prospective clinical study comparing a fine needle biopsy device and an aspiration needle.
- Trial name
- Expect (NCT02911974)
- Testing
- Acquire EUS Biopsy Device, Expect EUS Aspiration Needle
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- AdventHealth
Thyroid Cancer, Thyroid Nodule
The Ultracyt Study - is EU-TIRADS Useful in Selecting Nodules for Fine Needle Aspiration Cytology?
This is a randomized study evaluating selective fine-needle aspiration cytology based on structured ultrasound using EU-TIRADS versus non-selective ultrasound guided cytology.
- Trial name
- Ultracyt (NCT05583097)
- Testing
- Non-selective cytology
- Where
- Sweden
- Volunteers
- 195 people
- Sponsor
- Vastra Gotaland Region
Pancreatic Solid Lesions
The Comparison of Wet Suction and Dry Suction Technique in EUS-FNA for the Outcomes in Pancreatic Solid Lesions
The objective of this randomized controlled trial is to evaluate whether wet suction technique (WST), compared with dry suction technique (DST), shall present a better outcome with regard to the diagnostic yield and specimen…
- Trial name
- NCT03821974
- Testing
- wet suction technique, dry suction technique
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Abdominal Neoplasms
EUS GUIDED Transduodenal Biopsy Using the 19G Flex
This study evaluates the feasibility, safety and accuracy of a 19 gauge (19G) needle in nitinol in the performance of endoscopic ultrasound (EUS) guided transduodenal biopsy for the acquisition of samples for histologic analysis.
- Trial name
- NIFLEX (NCT02307253)
- Testing
- Expect™19Flex needle (Boston Scientific Corp.,Natick,MA,USA)
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 246 people
- Sponsor
- Catholic University of the Sacred Heart
Lesion Sampled for Cytology
Simple Technique to Improve Diagnostic Yield in EUS-FNA
Endoscopic ultrasound and fine needle aspiration are useful tools for the diagnosis and staging of pancreatic cancer. One potential limitation is contamination when needle traverses the gastrointestinal tract under continuous…
- Trial name
- NCT01995474
- Testing
- Twisted Syringe, Conventional Technique
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Breast Neoplasms
Study of Tumor RNA Disruption Assay™ (RDA)
The purpose of this study is to find out if the pathological complete response (pCR) to chemotherapy given before surgery (neoadjuvant chemotherapy) could be predicted by the evaluation of the RNA (ribonucleic acids) disruption…
- Trial name
- RnaDx (NCT02239315)
- Testing
- Tumor RNA Disruption Assay™ (RDA)
- Where
- 4 sites in Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Pancreatic Cancer, Lymphadenopathy
Beacon BNX™ Endoscopic Ultrasound (EUS)-Needle vs SharkCore™ Needle
The primary objective of this proposed prospective randomized, multi-center study is to evaluate the capability of the new 22G SharkCore™ needle to obtain tissue specimens and to compare its performance against the standard 22G…
- Conditions
- Pancreatic Cancer, Lymphadenopathy, Cholangiocarcinoma
- Trial name
- NCT02872831
- Testing
- 22G SharkCore™ needle, 22G BNX EUS-FNA Needle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pancreatic Neoplasms, Pancreatic Cancer
On-site Cytopathology EUS-FNA
This study is a multicenter prospective randomized controlled trial. Potential participants in this study include patients referred for Endoscopic Ultrasound-guided fine needle aspiration (EUS-FNA) of a solid pancreatic lesion at…
- Trial name
- NCT01386931
- Testing
- EUS-guided FNA performed with on-site Cytopathologist, EUS-guided FNA performed without on-site Cytopathologist
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Colorado, Denver
Cancer
Safety And Accuracy Study Of The Actisight™ Needle Guidance System In Patients Undergoing CT-Guided Procedures
This will be a prospective, single-arm, single-center, open-label study to evaluate the preliminary safety and accuracy of the ActiSight™ Needle Guidance System in patients undergoing CT-guided percutaneous aspiration and RF…
- Trial name
- NCT01040884
- Testing
- ActiSight Needle Guidance System
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- ActiViews Ltd.
Non Obstructive Azoospermia
Standard IV Cannula Aspiration (SIVCA): A Novel, Efficient and Minimally Invasive Testicular Sperm Aspiration Technique
Study question: Can enough testicular tissue be aspirated for sperm retrieval in non-obstructive azoospermia (NOA), using a wide bore 14-G Standard IV cannula in comparison to micro-TESE? Summary answer: Standard IV cannula…
- Trial name
- NCT05247723
- Testing
- Standard IV Cannula for aspiration of testicular sperm, Micro-TESE
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Cairo University