Clinical trials: Biopsy, Fine-Needle
Endoscopic Ultrasonography, EUS-FNA
Heparin-based Wet Suction Method in EUS Fine Needle Biopsy of Solid Pancreatic Mass
The objective of this randomized cross-over trial is to evaluate whether Heparin based wet suction technique, compared with dry suction technique, shall present a higher quality tissue core by using quantitative macroscopic and…
- Conditions
- Endoscopic Ultrasonography, EUS-FNA, Pancreatic Neoplasms
- Trial name
- NCT04707560
- Testing
- EUS fine needle biopsy with heparin wet suction
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Cheng-Kung University Hospital
Pancreatic Cancer
Evaluation of MMR Status and PD-L1 Expression Using Specimens Obtained by EUS-FNB in Patients With Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) has a suboptimal response to standard therapies that modestly impact survival due to its ability to evade host immune surveillance.
- Trial name
- SUCCESS (NCT03820921)
- Testing
- EUS-FNB, Immunohistochemistry
- Volunteers
- 30 people
- Sponsor
- Ponderas Academic Hospital
Pancreatic Neoplasm
Core Biopsy Endo Sonography Study Evaluation of the Significance of the Pro-core® Needle
The study is designed to evaluate the diagnostic accuracy of a new designed endoscopic ultrasonography (EUS) Core biopsy aspiration needle in comparison to a conventional EUS aspiration needle in GI-tumors.
- Trial name
- COS (NCT02181140)
- Testing
- EUS guided FNA and fine needle punction
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Neoplasms, Infection
A Multi-center, Prospective, Single-blind, Controlled Trial Comparing Diagnostic Value of Different EUS-FNA Techniques
The aim of this study is to compare endoscopic ultrasound guided-fine needle aspiration (EUS-FNA) with a standard 22-gauge needle using "standard suction", "slow-pull" and "wet suction" for thoracic/abdominal solid/solid-cystic…
- Conditions
- Neoplasms, Infection, Inflammation, Lymphoma
- Trial name
- EUS-FNA (NCT03674710)
- Testing
- Standard suction, slow-pull, wet suction, Standard suction, wet suction, slow-pull, Slow-pull, standard suction, wet suction
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Thyroid Nodules
Contrast-enhanced Ultrasound-guided Fine-needle Aspiration Biopsy in the Evaluation of Thyroid Nodules
To evaluate the application value of contrast-enhanced ultrasound in the diagnosis of thyroid nodules using fine needle aspiration.
- Trial name
- NCT03102099
- Testing
- contrast-enhanced ultrasound group, conventional ultrasound group
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Salivary Gland Tumor, Diagnosis
Diagnostic Accuracy of Fine Needle Aspiration in Patients With Salivary Gland Tumors.
Tumors of the salivary glands occupy 0.5-1.2% of cases of head and neck tumors. They are primarily a surgical disease, as their treatment is basically the surgical excision.
- Trial name
- NCT06034782
- Testing
- Fine Needle Aspiration, Histologic Examination
- Where
- Greece
- Volunteers
- 128 people
- Sponsor
- Aristotle University Of Thessaloniki
Thyroid Nodular Disease
Thyroid Fine Needle Biopsy and Impact on Pain and Diagnostic Adequacy
This randomized study compares patient pain and comfort during ultrasound-guided thyroid fine needle biopsy using 21-gauge versus 27-gauge needles. Patients with thyroid nodules were randomly assigned to one of two needle sizes.
- Trial name
- THY-BPSY (NCT07683039)
- Testing
- Thyroid fine needle biopsy with 21-gauge needle, Thyroid fine needle biopsy with 27-gauge needle
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Thyroid Nodule, Thyroid Neoplasm
Molecular Classifier for the Fine Needle-based Assessment of Malignancy Risk in Thyroid Nodules
This study evaluates the usefulness of molecular classifier to aid the diagnosis of malignancy in the material obtained by fine-needle aspiration biopsy (FNAB) of thyroid nodule.
- Conditions
- Thyroid Nodule, Thyroid Neoplasm, Thyroid Cancer
- Trial name
- ThyroPred-1 (NCT03392402)
- Where
- Poland
- Volunteers
- 599 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Lung Cancer
Trial of Endobronchial Ultrasound Guided Fine Needle Aspiration Techniques
Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TBNA) techniques have not been well studied. The investigators will conduct a randomized study comparing the diagnostic yield and specimen quality of…
- Trial name
- NCT01741571
- Testing
- EBUS guided FNA with and without suction
- Where
- Lebanon
- Volunteers
- 32 people
- Sponsor
- American University of Beirut Medical Center
Pancreas Neoplasms, Lymphatic Metastasis
Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on Solid Occupying Lesion
The purpose of this study is to compare the diagnosis accuracy of FNA and FNB biopsy on pancreatic, retroperitoneal, mediastinum and pelvic cavity solid occupying lesions.
- Conditions
- Pancreas Neoplasms, Lymphatic Metastasis, Neoplasm Metastases, Unknown Primary Neoplasm Metastasis
- Trial name
- NCT02327065
- Testing
- EUS-FNA (EchoTip Ultra), EUS-FNB (EchoTip ProCore)
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Huazhong University of Science and Technology
Other Specified Disorders of Esophagus, Stomach or Duodenum
EUS-FNA Versus KHB in Diagnostics of Upper Gastrointestinal Submucosal Tumors
Upper Gastrointestinal Submucosal Tumors are tumors arising from subepithelial layers of esophageal, gastric or duodenal wall. They usually have an intact mucosa lining on the inner surface.
- Trial name
- NCT02025244
- Testing
- Key Hole Biopsy ( KHB), EUS-FNA
- Where
- 2 sites in Czechia
- Volunteers
- 52 people
- Sponsor
- Vitkovice Hospital
Solid Pancreatic Mass Lesions, Malignant Neoplasm of Pancreas
Comparison of a Novel 22-gauge Core Biopsy Needle
The goal of this clinical research study is to compare the performance of a newly available needle with reverse bevel design (called the EchoTip® Procore™ needle) with standard needles to see which needle gives better diagnostic…
- Trial name
- NCT01598194
- Testing
- Novel 22-gauge Core Biopsy Needle + Standard Biopsy Needle
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatic Cancer, Hepatic Neoplasm
Endoscopic Ultrasound Guided Liver Biopsy
This is a prospective study to determine the optimal technique for obtaining liver tissue with a smaller caliber (22 gauge) needle and whether a good core biopsy can be obtained without the use of suction and secondly to…
- Conditions
- Hepatic Cancer, Hepatic Neoplasm, Hepatic Carcinoma
- Trial name
- NCT03307811
- Testing
- 22 gauge needle liver biopsy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AdventHealth
Leiomyoma, GIST
Detective Flow Imaging Endoscopic Ultrasonography in Subepithelial Lesions
Gastrointestinal stromal tumors (GIST) are the most common malignant subepithelial lesions (SELs) found in the gastrointestinal tract.
- Trial name
- NCT05474794
- Testing
- DFI-EUS, CE-EUS
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Thyroid Nodule, Diagnoses Disease
Diagnostic Significance of CTCs in Patients With Thyroid Nodules (Circulating Tumor Cells)
Thyroid nodule patients with suggestion of fine needle aspiration biopsy (FNAB) offered by ultrasound are enrolled in the study. CTCs tested by Optimizing method and FNAB will be performed simultaneously.
- Trial name
- CTCs (NCT03772496)
- Testing
- circulating tumor cells test, Fine needle aspiration biopsy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Solid Pancreatic Masses
Endoscopic Ultrasound-guided Fine Needle Biopsy With 25-gauge Biopsy Needles for Solid Pancreatic Masses
For 12 months after approvement by the University of Yonsei institutional review board, of the 59 patients older than 20 years referred to our medical center for EUS-FNA or FNB, all consecutive pancreatic lesions were evaluated…
- Trial name
- NCT01795066
- Testing
- EUS-FNB with 25-gauge (Echotip ProCore; Cook Endoscopy Inc, Limerick, Ireland)
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Thermal Ablation, Fine Needle Aspiration Biopsy
Ultrasound and Cytological Evaluation 3 Years After Radiofrequency Thermal Ablation of Benign Thyroid Nodules : a Prospective Exploratory Cohort of 180 Nodules
There is no scientific data on post-thermal ablation cytological aspects, but treated nodules that grow back significantly after a procedure justify a new cytology in order not to ignore a neoplastic process.
- Conditions
- Thermal Ablation, Fine Needle Aspiration Biopsy, Thyroid Nodules
- Trial name
- CYTOTHYRAF (NCT05726981)
- Testing
- Fine needle aspiration biopsy (FNAB)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Tumor, Fine Needle Aspiration
Comparison of Two Needles (ProCore vs EchoTip) for the Diagnosis of Pancreatic Solid Mass Under EUS
The negative predictive value of fine needle aspiration under ultrasound endoscopy (EUS) for the diagnostic of solid pancreatic masses is 70% on average in the current literature with 22 gauge needles.
- Conditions
- Pancreatic Tumor, Fine Needle Aspiration, Endoscopic Ultrasonography
- Trial name
- PICORE (NCT01479803)
- Testing
- Puncture with fine needle aspiration under endoscopic ultrasonographic control
- Where
- France
- Volunteers
- 80 people
- Sponsor
- VANBIERVLIET
Pancreatic Neoplasms
Diagnostic Yield of 20-gauge Procore Needle for EUS-guided FNA Biopsy in Solid Pancreatic Lesions
This study aims to examine technical feasibility and diagnostic yield of new 20-gauge Procore needle for EUS-guided fine needle biopsy in solid lesions by comparing with 22-gauge Procore needle.
- Trial name
- NCT02920944
- Testing
- EUS-FNB with 20 gauge ProCore needle, EUS-FNB with 22 gauge ProCore needle
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seung Bae Yoon
Pancreatic Cyst
Usefulness of Contrast Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Cysts
The study evaluates the role of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) for the differentiation of the pancreatic cysts and their malignant potential.
- Trial name
- NCT04389892
- Testing
- Contrast enhanced harmonic endoscopic ultrasound
- Where
- Romania
- Volunteers
- 58 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy