Clinical trials: Biventricular Failure
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Heart Failure, Biventricular Failure
BiVACOR® Total Artificial Heart Early Feasibility Study
The purpose of this study is to assess the feasibility of using the BiVACOR Total Artificial Heart (TAH) System to support adult patients with severe biventricular heart failure, or univentricular heart failure in which left…
- Trial name
- NCT06174103
- Testing
- BiVACOR TAH System
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- BiVACOR Inc.
Heart Failure, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure
The purpose of this study is to evaluate the efficacy and safety of conduction system pacing versus biventricular pacing in patients with chronic heart failure with reduced ejection fraction and left bundle branch block.
- Conditions
- Heart Failure, Left Bundle-Branch Block, Cardiac Resynchronization, Conduction System Pacing
- Trial name
- PhysioSync-HF (NCT05572736)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- 14 sites in Brazil
- Volunteers
- 179 people
- Sponsor
- Hospital Moinhos de Vento
Heart Failure
Stimulation of the Diaphragm in Patients With Severe Heart Failure Following Heart Surgery
This study examines whether a permanent stimulation of the diaphragm improves left ventricular function in patients with severe heart failure following heart surgery.
- Trial name
- NCT00769678
- Testing
- Stimulation of the diaphragm
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Luzerner Kantonsspital
End-stage Heart Failure
Echocardiographic Assessment of the Effect of Impella on Biventricular Function
The objective of this prospective observational study is to evaluate the effects of Impella 5.5 on biventricular function in adult patients with end-stage heart failure requiring temporary mechanical circulatory support.
- Trial name
- NCT07534462
- Testing
- Echocardiographic Assessment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Rochester
Bradyarrhythmia, Pacemaker Syndrome
Bi-ventricular Epicardial Activation in Left Bundle Area Pacing: a Comparison Study
Study of the ventricular activation patterns during left bundle area pacing and compare it with baseline activation during normal sinus rhythm in patients with and without baseline bundle branch conduction disorder.
- Conditions
- Bradyarrhythmia, Pacemaker Syndrome, Biventricular Cardiac Pacemaker Malfunction
- Trial name
- LBBAP (NCT05401851)
- Testing
- Left Bundel Area Pacing
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Heart Failure
The Effects of Anodal Stimulation on Echocardiographic Outcome in Patients With Cardiac Resynchronization Therapy
To investigate the hemodynamic, inter and intraventricular desynchrony effects of anodal stimulation and triple site pacing compared with the usual dual site pacing by echocardiography and Tissue Doppler Imaging.
- Trial name
- NCT00825006
- Testing
- Triple site pacing mode
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation
MODULA Modul 7 VRR
This study will look at the correlation between ventricular rate regulation (VRR) and the percentage of biventricular pacing as well as subjective quality of life and level of physical ability in CRT patients with atrial…
- Trial name
- NCT00180414
- Testing
- CRT devices with ventricular rate regulation [VRR] (CE labeled)
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Left Ventricular Dysfunction
Predicting Response to Cardiac Resynchronization Therapy in Heart Failure
This study will explore which characteristics of patients with heart failure will likely predict improvement after cardiac resynchronization (CRT), implantation of a pacemaker to improve heart function.
- Trial name
- NCT00359372
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Cardiac Pacing, Artificial
Acute Effects of LBBP Versus BVP for CRT
The study was designed to compare the acute effects of left bundle branch pacing (LBBP) with biventricular pacing (BVP) in patients with left ventricular ejection fraction (LVEF) <=35% with left bundle branch block (LBBB).
- Conditions
- Heart Failure, Cardiac Pacing, Artificial, Cardiac Resynchronization Therapy
- Trial name
- NCT04505384
- Testing
- left bundle branch pacing, biventricular pacing
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure
Single Dose Escalation Study in Patients With Chronic Heart Failure
This study is to demonstrate the safety and tolerability of a single oral dose of BAY60-4552 in a single dose escalation design.
- Trial name
- NCT00565565
- Testing
- BAY60-4552
- Where
- 2 sites in Germany
- Volunteers
- 55 people
- Sponsor
- Bayer
Heart Failure, Cardiomyopathy
Correlating QLV Interval to Left Ventricular (LV) Lead Position in Patients Receiving Cardiac Resynchronization Therapy.
This is a prospective clinical trial to determine the optimal QLV interval during implantation to achieve the best possible response from cardiac resynchronization therapy for heart failure patients.
- Conditions
- Heart Failure, Cardiomyopathy, Cardiac Arrhythmia
- Trial name
- QLV (NCT02166762)
- Testing
- QLV interval measurement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Heart Failure, Cardiac Resynchronization Therapy
Echocardiography in Cardiac Resynchronization Therapy (Echo-CRT)
The present observational prospective study aims at identifying echocardiographic parameters (based on the Left Bundle Branch Block (LBBB)-like contraction of the left ventricle (LV) ascertained using new methods of…
- Trial name
- Echo-CRT (NCT02986633)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Lille Catholic University
Heart Failure With Reduced Ejection Fraction
Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Randomized trial of adult patients to study the effects of preferential left ventricular pacing on ventriculoarterial coupling of both systemic and pulmonary circulation, indices of systolic and diastolic function of both…
- Trial name
- READAPT (NCT04420065)
- Testing
- Preferential left ventricular pacing, Biventricular pacing
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- National and Kapodistrian University of Athens
Heart Failure
Assessment of Efficacies of Cardiac Resynchronization Therapies (CRT-P/D) for Heart Failure Patients in China
The ADOPT study is a prospective, nested case-controlled and open label clinical trial. About 40 centers across China participate in this study with a planned 800 Chinese cases enrollment.
- Trial name
- ADOPT (NCT01018667)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xijing Hospital
Heart Failure, Congestive, Cardiac Pacing, Artificial
Effect of Targeting Left Ventricular Lead Position on the Rate of Response to Cardiac Resynchronization Therapy.
Identifying \& optimizing strategies to reduce the burden of heart failure is vital. Despite advances in pharmacotherapy, patients with heart failure are at high risk for death \& hospitalization.
- Conditions
- Heart Failure, Congestive, Cardiac Pacing, Artificial, Defibrillators
- Trial name
- INCREMENTAL (NCT00399594)
- Testing
- A, B
- Where
- 3 sites in Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Chronic Heart Failure
Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy
The present study will recruit 40 symptomatic heart failure patients with left ventricular ejection fraction (LVEF) below 35% and complete left bundle branch block(QRSd≥130 ms).
- Trial name
- LBBP-RESYNC (NCT04110431)
- Testing
- Left bundle branch pacing, Biventricular pacing
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Failure, Right-Sided, Cardiac Failure
Syncardia 50cc TAH-t as a Bridge to Transplant
The primary objective of the study is to evaluate whether the 50cc TAH-t can safely support, and provide probable benefit to, transplant-eligible pediatric patients (aged 10 - 18 years) and can safely and effectively support…
- Conditions
- Heart Failure, Right-Sided, Cardiac Failure, Heart Failure, Left-Sided
- Trial name
- NCT02459054
- Testing
- SynCardia 50cc temporary Total Artificial Heart (TAH-t)
- Where
- 26 sites in United States
- Volunteers
- 16 people
- Sponsor
- SynCardia Systems. LLC
Chronic Heart Failure
Biventricular or Left Bundle Branch Pacing to Assess the Effect of Cardiac Resynchronization Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation
In this prospective, randomized, multicenter, open-label interventional clinical trial, the investigators' aim to test the effect of Cardiac Resynchronization Therapy (CRT) in cases of new-onset and persistent Left Bundle Branch…
- Trial name
- BUDAPEST-TAVI (NCT07434193)
- Testing
- CRT implantation
- Where
- Hungary
- Volunteers
- 360 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Heart Failure
MultiPoint Pacing™ Post Market Study
This is a prospective, multicenter, non-randomized registry/observational study. The study will enroll up to 2,000 patients with successful St.
- Trial name
- MPP-PMS (NCT02832622)
- Testing
- MPP, BiV/MPP
- Where
- 128 sites in United States, Argentina and 2 more
- Volunteers
- 2,169 people
- Sponsor
- Abbott Medical Devices