Clinical trials: Bladder
Urinary Bladder, Overactive, Effect of Drug
Efficacy of Combined Pharmacotherapy Versus Solifenacin With Vaginal Estrogen Cream for Women With Detrusor Overactivity
To investigates the effects of combined pharmacotherapy with solifenacin and mirabegron versus solifenacin with vaginal estrogen cream in women with detrusor overactivity.
- Trial name
- NCT06197295
- Testing
- Solifenacin with vaginal estrogen cream, Combination pharmacotherapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Mackay Memorial Hospital
Stage III Bladder Cancer, Stage IV Bladder Cancer
Comparison of Immediate and Delayed Adjuvant Chemotherapy in Treating Patients Who Have Undergone a Radical Cystectomy for Stage III or Stage IV Transitional Cell Carcinoma of the Bladder Urothelium
Randomized phase III trial to compare the effectiveness of immediate adjuvant chemotherapy with that of adjuvant chemotherapy given when the cancer returns in treating patients who have undergone a radical cystectomy for stage…
- Conditions
- Stage III Bladder Cancer, Stage IV Bladder Cancer, Transitional Cell Carcinoma of the Bladder
- Trial name
- NCT00028756
- Testing
- doxorubicin hydrochloride, gemcitabine hydrochloride, vinblastine sulfate
- Volunteers
- 285 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Overactive Bladder (OAB)
RELIEVE Study: NT 201 Intravesical Administration Using Vibe System (ViXe Combination Product) for the Treatment of Idiopathic Overactive Bladder
This Phase 2b study is a prospective, multicenter, double blind, randomized, placebo and sham controlled trial to assess the safety, efficacy and dose response of NT 201 delivered by the Vibe System in participants with…
- Trial name
- RELIEVE (NCT07553065)
- Testing
- NT 201 200U and Vibe System, NT 201 300U and Vibe System
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Vensica Therapeutics Ltd.
Renal Cell Carcinoma, Urinary Bladder Neoplasms
Phase I/Ib Study of Pembrolizumab With Vorinostat for Patients With Advanced Renal or Urothelial Cell Carcinoma
Primary objective: To assess the early signals for anti-tumor activity (i.e. objective response rate, progression-free survival) of pembrolizumab in combination with vorinostat in patients with advanced prostate, renal or…
- Trial name
- NCT02619253
- Testing
- Pembrolizumab, Vorinostat
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Nabil Adra
Overactive Bladder, Urge Urinary Incontinence
Safety and Applicability Study of a Novel Heat Flow Sensor Unit for Measuring Urinary Bladder Capacity
A novel sensor (a device named sensurine)was developed in the aim of real- time measurement of bladder volume. The sensurine device is a wearable, fully passive, non-invasive and compact heat flow sensor (patent pending) and…
- Conditions
- Overactive Bladder, Urge Urinary Incontinence, Enuresis, Self Clean Intermittent Catheterization
- Trial name
- NCT00437528
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bladder Cancer
Complete Local Response to Neoadjuvant Chemotherapy in Patients With Muscle Invasive Bladder Cancer Evaluated by 15O-H2O PET/MR
Treatment of localized muscle invasive bladder cancer (MIBC) is radical cystectomy. Neoadjuvant chemotherapy (NAC) improves survival.
- Trial name
- MAINTAIN (NCT04321707)
- Testing
- 15O-H2O PET/MR
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Jørgen Bjerggaard Jensen
Neoplasm
A Phase I Study of Systemic Gene Therapy With SGT-94 in Patients With Solid Tumors
This is a Phase I study designed to evaluate the safety and maximum tolerated dose (MTD) of SGT-94, a novel, tumor-targeted, systemic gene therapy agent for cancer.
- Trial name
- SGT94-01 (NCT01517464)
- Testing
- SGT-94
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- SynerGene Therapeutics, Inc.
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Lapatinib, Cisplatin, Gemcitabine as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urothelial Cancer
RATIONALE: Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, and gemcitabine, work in different ways to stop the growth of tumor…
- Trial name
- NCT00623064
- Testing
- cisplatin, gemcitabine hydrochloride, lapatinib ditosylate
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Overactive Bladder (OAB), Urinary Urgency
APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women
The APPROVE trial is a multi-centered, randomized controlled trial designed to assess differences in symptom improvement, quality of life, bladder symptoms, satisfaction with treatment and continued treatment efficacy in women…
- Conditions
- Overactive Bladder (OAB), Urinary Urgency, Urinary Urge Incontinence (UUI), Nocturia
- Trial name
- APPROVE (NCT06797245)
- Testing
- RiSolve App, AUGS Patient Handouts
- Where
- 10 sites in United States
- Volunteers
- 596 people
- Sponsor
- Medstar Health Research Institute
Bladder (Urothelial, Transitional Cell) Cancer, Bladder Cancer
Xpert Bladder Monitor: a Non-Invasive Follow-Up Tool for Detecting Relapse in High Grade or High Risk Bladder Cancer
Main objectives: Qualitative and quantitative monitoring of recurrences in patients with a previous diagnosis of high-grade bladder cancer at high risk of persistence/recurrence.
- Conditions
- Bladder (Urothelial, Transitional Cell) Cancer, Bladder Cancer, Bladder Tumors, Bladder Cancer Recurrence
- Trial name
- LIBERO (NCT06751667)
- Testing
- Urinary biomarkers
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Urinary Bladder, Overactive
Evaluating the Change of Overactive Bladder Symptoms in Women Post Pubovaginal Sling Procedure for Stress Incontinence
Pubovaginal sling (PVS) procedures are designed to curtail bladder leakage brought about by strenuous events such as child birth.
- Trial name
- NCT01194999
- Testing
- Pubovaginal sling procedure
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- Barrie Urology Associates
Advanced Bladder Cancer
The Impact of Time-of-day Administration of EV/P on Objective Response Rate in Adults With Advanced Bladder Cancer
The goal of this clinical trial is to learn if the timing of treatments plays a role in how effective the standard-of-care drugs enfortumab vedotin and pembrolizumab (EV/P) works to treat adults with advanced bladder cancer.
- Trial name
- Chrono-EVP (NCT07346053)
- Testing
- enfortumab vedotin and pembrolizumab (EV/P)
- Where
- 5 sites in Canada
- Volunteers
- 224 people
- Sponsor
- Guliz Ozgun
Overactive Bladder
Assessment of Patient-reported Goal Attainment in the Treatment of Female Overactive Bladder
For many years, antimuscarinics have been first-line pharmacological treatment for OAB. A recent meta-analysis of randomised, controlled trials on antimuscarinic treatment of OAB concluded that the drugs provide significant…
- Trial name
- NCT00836381
- Testing
- Tolterodine extended-release (ER) 4mg
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Samsung Medical Center
Bladder, Lower Urinary Track Symptoms
Low-Energy Shock Wave Therapy for Overactive Bladder in Women With Metabolic Syndrome
Overactive bladder (OAB) is a common condition that causes urinary urgency, frequent urination, and nocturia, which can significantly affect quality of life.
- Conditions
- Bladder, Lower Urinary Track Symptoms, Metabolic Syndrome, Urgency-Frequency
- Trial name
- NCT07563764
- Testing
- Low-Energy Extracorporeal Shock Wave Therapy (LiESWT)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- KMUHIRB-F(I)-20230051
Orthotopic Neobladder
The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.
Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain…
- Trial name
- NCT05558111
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Overactive Bladder Syndrome, Enuresis, Nocturnal
Overactive Bladder Syndrome
Purpose: A lot of etiological factors related to overactive bladder (OAB) has been investigated. However, the role of primary nocturnal enuresis (NE), which is characterized with childhood night time incontinence, in the etiology…
- Trial name
- NCT05151081
- Testing
- basicly
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Hisar Intercontinental Hospital
Carcinoma, Transitional Cell, Bladder Cancer
Study of Pralatrexate to Treat Advanced or Metastatic Relapsed Transitional Cell Carcinoma of the Urinary Bladder
The purpose of this study is to determine whether pralatrexate, given with vitamin B12 and folic acid, is effective in the treatment of advanced or metastatic bladder cancer.
- Conditions
- Carcinoma, Transitional Cell, Bladder Cancer, Bladder Neoplasm
- Trial name
- NCT00722553
- Testing
- Pralatrexate Injection, Vitamin B12, Folic Acid
- Where
- 19 sites in United States, Argentina and 4 more
- Volunteers
- 30 people
- Sponsor
- Acrotech Biopharma Inc.
Overactive Bladder Syndrome
Efficacy, Tolerability and Impact on Quality of Life of Propiverine in Patients With Overactive Bladder Syndrome
The purposes of this study were to assess Quality of Life (QoL) and urination urge, incontinence, and micturition frequency including nocturia after 4 and 12 weeks treatment with propiverine.
- Trial name
- NCT02024945
- Testing
- Propiverine
- Volunteers
- 437 people
- Sponsor
- Takeda
Bladder Cancer, Prostate Cancer
Occupational Situation and Return to Work of Urological Patients
This study will examine the work status of all adult patients admitted over a 6-month period to the University Hospital in Kraków, Poland, for treatment of urological diseases.
- Conditions
- Bladder Cancer, Prostate Cancer, Renal Cancer, Urinary Stones
- Trial name
- OCCURORTW (NCT07088536)
- Testing
- Occupational Status Survey and Telephone Follow-up and Quality-of-Life Assessment in a subset of patients
- Where
- Poland
- Volunteers
- 2,000 people
- Sponsor
- Jagiellonian University
Dysfunctional Voiding, Urinary Dysfunction
At-Home Diaphragmatic Interventions for Voiding Abnormalities (DIVA)
The goal of the DIVA trial is to test the effectiveness of at-home diaphragmatic breathing exercises with bladder hygiene education in female patients with symptoms of difficulty urinating (dysfunctional voiding).
- Trial name
- DIVA (NCT06165731)
- Testing
- Diaphragmatic Breathing Exercises, Bladder Hygiene Education
- Where
- 2 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Duke University
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