Clinical trials: Bleed Intracranial
Hypertension, Intracranial Hemorrhage
The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy
This study is a single-arm, open label protocol evaluating the use of Cleviprex to rapidly control hypertension in patients who present with intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH), and that require ICP…
- Conditions
- Hypertension, Intracranial Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT01042574
- Testing
- Clevidipine butyrate
- Where
- United States
- Sponsor
- Methodist Healthcare - Memphis
Intracerebral Hemorrhage, Acute Stroke
Remote Ischemic Conditioning for the Treatment of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) results from the rupture of small vessels damaged by chronic hypertension, amyloid angiopathy or other disease. Currently, ICH has been a devastating type of stroke that lacking effective therapy.
- Trial name
- RICH-2 (NCT04657133)
- Testing
- Remote ischemic conditioning, Standard medication therapy
- Where
- 13 sites in China
- Volunteers
- 452 people
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage, Subarachnoid Hemorrhage
Al Prediction of Sarcopenia Risk in Neurocritical ICU Patients
This prospective observational study aims to evaluate sarcopenia in intensive care patients with intracranial pathologies using ultrasound and to compare the predictive performance of different artificial intelligence models.
- Conditions
- Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Epidural Hematoma
- Trial name
- NCT07712198
- Testing
- Prospective Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Chronic Subdural Hematomas, Cerebral Compression Due to Injury
Middle Meningeal Artery Embolization for Chronic Subdural Hematomas (STORMM)
Chronic Subdural Hematomas (cSHD) are common, and due to cerebral compression, often result in neurological impairment and reduced consciousness. Surgery is typically performed once neurological symptoms develop.
- Trial name
- STORMM (NCT06163547)
- Testing
- MMA embolization
- Where
- 2 sites in Switzerland
- Volunteers
- 180 people
- Sponsor
- University Hospital, Geneva
Subarachnoid Hemorrhage, Aneurysmal, Cognitive Dysfunction
Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH
The goal of this clinical trial is to Explore and verify whether 40Hz audio and binaural beat 40Hz audio can improve the postoperative cognitive dysfunction seen in patients with aneurysmal subarachnoid hemorrhage.
- Trial name
- GES-aSAH (NCT06346015)
- Testing
- Gamma Entrainment Stimulation
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Vasospasm, Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation in Patients With Cerebral Vasospasm After Subarachnoid Haemorrhage: VasoStim Study
Cerebral vasospasm is characterized by a vasoconstriction of cerebral arteries causing a reduction of cerebral blood flow (CBF) and leading to ischemia and infarction of the brain parenchyma.
- Trial name
- NCT05150002
- Testing
- Spinal cord stimulation
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage, Aneurysmal
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage
Aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, which is in part due to the development of secondary brain injury.
- Trial name
- NOX2 (NCT05686265)
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Subarachnoid Haemorrhage (SAH)
Serum GFAP and UCHL1: Evaluation of Their Predictive Value for SAH
To verify the analytical performance of GFAP and UCH-L1 biomarkers marketed by Abbott Diagnostics and to assess diagnostic accuracy of these biomarkers in predicting subarachnoid haemorrhage
- Trial name
- SAH (NCT06581757)
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Stroke
"Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy
This clinical trial will enroll 110 patients from approximately 15 Canadian stroke centres. Patients coming to the emergency department with bleeding in the brain not due to trauma or other known causes who can be treated within…
- Trial name
- SPOTLIGHT (NCT01359202)
- Testing
- rfVIIa, Standard saline solution
- Where
- 15 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Dr. David Gladstone
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a special type of stroke that typically results from a ruptured intracranial aneurysm, a weakening in the wall of a blood vessel.
- Trial name
- NCT01865630
- Testing
- Etanercept
- Where
- Canada
- Sponsor
- Unity Health Toronto
Intracerebral Hemorrhage
Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage
This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. It aims to evaluate the efficacy and safety of oral minocycline in patients with acute spontaneous intracerebral hemorrhage within…
- Trial name
- MISTICH (NCT07338175)
- Testing
- Minocycline hydrochloride capsules
- Where
- 41 sites in China
- Volunteers
- 1,192 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage Lobar
Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage
The goal of this clinical trial is to assess the safety and tolerability of colchicine for preventing intracerebral haemorrhage (ICH) recurrence in patients with cerebral amyloid angiopathy (CAA)-ICH at high risk of recurrence.
- Trial name
- CARE-ICH (NCT07026994)
- Testing
- Colchicine 0.5mg
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Huashan Hospital
Intracerebral Hemorrhage
Dose Finding and Safety Study of Deferoxamine in Patients With Brain Hemorrhage
Animal studies show that the breakdown of blood results in iron accumulation in the brain after brain hemorrhage (ICH); and that iron plays a role in brain injury in ICH patients.
- Trial name
- DFO In ICH (NCT00598572)
- Testing
- Deferoxamine Mesylate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Subarachnoid Hemorrhage (SAH)
Serum Procalcitonin
Systemic inflammatory response syndrome (SIRS) is characterized by changes in body temperature, heart rate, respiratory rate, or peripheral blood white cell count, and is often a heralding manifestation of blood infection (ie.…
- Trial name
- NCT00954551
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Subarachnoid Hemorrhage
Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage
The hypothesis is that intravenous infusion of sodium nitrite is safe and effective for the reversal of cerebral vasospasm after subarachnoid hemorrhage in patients with a cerebral aneurysm.
- Trial name
- NCT02176837
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Hope Pharmaceuticals
Subarachnoid Hemorrhage
Preconditioning for Aneurismal Subarachnoid Hemorrhage
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke.
- Trial name
- NCT01110239
- Testing
- remote limb preconditioning
- Volunteers
- 34 people
- Sponsor
- University of Miami
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Treatment of Chronic Subdural Hematoma
Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach has been attempted with the goal of eliminating the arterial supply to the vascularized membrane.
- Trial name
- NCT03307395
- Testing
- Middel Meningeal Artery Embolization
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Stroke Hemorrhagic, Depression
Poststroke Depression in Hemorrhagic Stroke
A double-blinded placebo-controlled randomized trial to evaluate the effect of preventative treatment of depression in survivors of aneurysmal subarachnoid hemorrhage (aSAH), a type of stroke.
- Trial name
- NCT03826875
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Washington
Chronic Subdural Hematoma
YL-1 Needle Puncture vs BHC With Postoperative Exhaustive Drainage for CSDH
A prospective multicenter cohort study was designed to compare the differences in complications with YL-1 Needle Puncture versus Bulr-hole Craniotomy (BHC) with postoperative Exhaustive Drainage strategy for patients with Chronic…
- Trial name
- NEBULA (NCT06072053)
- Testing
- Burr Hole Craniostomy and Postoperative Exhaustive Drainage Strategy, YL-1 puncture needle and Postoperative Exhaustive Drainage Strategy
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Beijing Tiantan Hospital
Obstructive Hydrocephalus, Subarachnoid Hemorrhage
VisAR Augmented Reality Navigation of Ventriculostomy
This study is intended to evaluate the feasibility of using VisAR augmented reality surgical navigation during placement of an external ventricular drain (EVD).
- Conditions
- Obstructive Hydrocephalus, Subarachnoid Hemorrhage, Brain Trauma
- Trial name
- NCT06132139
- Testing
- VisAR
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
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