Clinical trials: Bleeding Post Cardiac Surgery
Perioperative Bleeding, Coagulopathy During Cardiac Surgery
Flow-Based Platelet Function Assessment Using Total Thrombus-Formation Analysis System (T-TAS) and Early Bleeding After Cardiac Surgery With Cardiopulmonary Bypass (CPB)
The goal of this observational study is to learn how flow-based platelet function measured with the Total Thrombus-formation Analysis System (T-TAS) relates to early postoperative bleeding in adults undergoing cardiac surgery…
- Conditions
- Perioperative Bleeding, Coagulopathy During Cardiac Surgery, Platelet Dysfunction, Cardiac Surgery
- Trial name
- TTAS-CPB (NCT07619261)
- Testing
- Total Thrombus-formation Analysis System (T-TAS)
- Volunteers
- 30 people
- Sponsor
- Hospital de la Santa creu i Sant Pau - Barcelona
Atrial Fibrillation New Onset, Hemorrhage
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
- Conditions
- Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia
- Trial name
- NCT01590979
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Open Heart Surgery
Dose for Reversal of Heparin After Cardiopulmonary Bypass
Protamine sulfate is routinely used to reverse heparin anticoagulation after cardiopulmonary bypass (CPB). The conventional dosing strategy of 1 mg protamine per 100 IU of heparin may result in excess protamine exposure, which…
- Trial name
- NCT07477977
- Testing
- Protamine sulfate
- Where
- Egypt
- Volunteers
- 195 people
- Sponsor
- Sohag University
Thoracic Surgery, Heart Diseases
Extended Perioperative Administration of Fibrinolysis Inhibitors After Cardiac Surgery
PRIORITY is a pragmatic, multi-center, cluster crossover trial that aims to evaluate whether implementing a policy of routine extended (intraoperative and 4 hour after transfer to ICU) use of fibrinolysis inhibitors leads to a…
- Conditions
- Thoracic Surgery, Heart Diseases, Fibrinolysis Shutdown
- Trial name
- PRIORITY (NCT06493227)
- Testing
- No routine fibrinolysis inhibitors after surgery, Routine fibrinolysis inhibitors after surgery
- Where
- 2 sites in Russia
- Volunteers
- 1,373 people
- Sponsor
- Saint Petersburg State University, Russia
Heart Failure, Ventricular Dysfunction
The Use of CoSeal (Sealant Agent) in Patients During Left Ventricular Assist Device Surgery
The purpose of this study is to evaluate the use of a device called CoSeal™. CoSeal™ is an FDA approved synthetic (man-made) surgical sealant which is currently used to help stop leaks in blood vessels during surgery.
- Trial name
- NCT01605019
- Testing
- CoSeal, BioGlue® Surgical Adhesive
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- The Methodist Hospital Research Institute
Hot Climate, Bleeding Tendency
Hot Climate on Bleeding Tendency After Cardiac Surgery in Egyptian Patients
This work aimed to assess the effect of regional climatic differences on postoperative bleeding in Egyptian patients undergoing cardiac surgery with cardiopulmonary bypass, by comparing outcomes between patients from hot climate…
- Conditions
- Hot Climate, Bleeding Tendency, Cardiac Surgery, Egyptian Patients
- Trial name
- NCT07510022
- Testing
- Open heart surgery
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Al-Azhar University
Cerebral Hemorrhage, Head Injury
Biomarkers Correlation With Volemia
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7…
- Conditions
- Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure
- Trial name
- ENVOL (NCT01858675)
- Testing
- Biomarkers, red blood cells and plasma assessment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France
Hemorrhage
Trial Comparing Tisseel as an Adjunct to Traditional Hemostasis After Redo Cardiac Surgery
Bleeding after redo cardiac surgery is a common, unresolved and consequences-heavy event as per present day. Tisseel (Baxter inc) sprayed on the already hemostased mediastinum jut before closing seems a promising technique to…
- Trial name
- RETICO (NCT02360800)
- Testing
- Spray Fibrin Sealant, Traditional Hemostasis and chest Closure Routine
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Cardiochirurgia E.H.
Surgical Blood Loss, Surgical Complication
Usability of Pericardial Flushing with the Haermonics Pure System After Cardiac Surgery
The goal of this clinical trial is to evaluate the usability of the Haermonics Pure system in patients undergoing a cardiac surgery procedure with the use of cardiopulmonary bypass.
- Trial name
- USEPURE (NCT06521164)
- Testing
- Haermonics Pure system
- Volunteers
- 65 people
- Sponsor
- Haermonics BV
Coronary Artery Disease
Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery
The goal of this project is to determine whether the use of tranexamic acid, a clot-promoting drug, applied topically over the heart in coronary artery bypass graft surgery (CABG) will reduce post operative blood loss.
- Trial name
- NCT01519245
- Testing
- Tranexamic Acid, normal saline
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Coronary Artery Disease
Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery.
Running title: Effect of Clopidogrel on Postoperative Bleeding in Patients undergoing Coronary Artery Bypass Surgery Title: Clopidogrel and bleeding in patients undergoing coronary artery bypass grafting.
- Trial name
- NCT00724880
- Testing
- Clopidogrel
- Volunteers
- 135 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Cardiopulmonary Bypass
The Effect of Washing Red Blood Cells on Post Heart Surgery Blood Loss
When a child undergoes heart surgery, a heart lung machine is used to keep blood flowing while the child's own heart is stopped. After surgery, a significant amount of the child's own blood is left in this machine.
- Trial name
- NCT00624611
- Testing
- Residual pump blood management post aortic cannula removal
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of British Columbia
Cardiac Surgery, Bleeding
Adjusted Calculation of Heparin and Protamin Dosing and Correlation With Postoperative Bleeding and Transfusions
The study will compare a novel calculation model (HeProCalc AB) with a standard weight-based and activated clotting time adjusted calculation for the dosing of Heparin and protamine and assess the impact on postoperative bleeding…
- Conditions
- Cardiac Surgery, Bleeding, Transfusion, Protamine Sulfate
- Trial name
- NCT02785575
- Testing
- HeProCalc algorithm
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Cardiac Disease, Bleeding Postoperative
Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass
Autologous blood transfused at the end of cardiopulmonary bypass will reduce total blood loss 24 hours after surgery and improve mitochondrial oxygen delivery measured by plasma succinate levels.
- Trial name
- NCT03204357
- Testing
- Fresh Autologous whole Blood, Standard of Care Expectant management of bleeding
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Off Pump Coronary Artery Bypass Surgery
Tranexamic Acid in Off-pump Coronary Surgery
The aim of this prospective, randomized, double-blinded, placebo-controlled study was to evaluate the effects of tranexamic acid, a synthetic antifibrinolytic drug, on the postoperative bleeding and transfusion requirements in…
- Trial name
- TAOPCAB (NCT01064167)
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 231 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Disease, Coagulopathy
Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding
Open-heart surgery frequently results in abnormal clotting, which in turn results in excessive blood loss and the need for transfusion of multiple blood products to patients and leads to adverse outcomes.
- Trial name
- NCT00188747
- Testing
- Thromboelastograph, Point of Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Cardiac Surgery, Cardiopulmonary Bypass
Clinical Trial Comparing Heparin and Protamine Fixed and Titrated Doses in Cardiac Surgery With Cardiopulmonary Bypass
There are currently several schemes described for anticoagulation with heparin and its reversal with protamine during cardiac surgery with CPB.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Anticoagulation
- Trial name
- NCT01267487
- Testing
- Heparin fixed doses, PO continuous infusion of Protamine, Heparin and protamine titration
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- SANE-Society of Anesthesiology
Coronary Artery Disease, Valvular Heart Disease
Efficacy of Sternum Guard in Post Cardiac Surgery Patient
This is a single-center, single-blind, randomized parallel superiority trial comparing two groups; Sternum GuardTM as the treatment arm and Bone Wax as the active control group.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Congenital Heart Disease in Adolescence, Post Operative Wound Infection
- Trial name
- NCT05229276
- Testing
- Sternum Guard, Bone Wax
- Where
- Indonesia
- Volunteers
- 414 people
- Sponsor
- Universitas Indonesia
Cardiopulmonary Bypass
Prothrombin Complex Concentrate (PCC)
The overall objective of this study is to determine whether ROTEM (rotational thromboelastometry) guided dosing of four-factor prothrombin complex concentrate (4F-PCC) results in superior perioperative bleeding control compared…
- Trial name
- NCT07881393
- Testing
- Four Factor Prothrombin Complex Concentrate, ROTEM (Rotational Thromboelastometry) analyzer (TEM International GmbH)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Coronary Artery Disease, Valvular Heart Disease
Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery
This is a single-center, double-blind, randomized controlled trial (RCT) comparing two groups of application of topical dose of tranexamic acid (TxA) versus placebo in patients undergoing coronary artery bypass graft (CABG), off…
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Surgical Blood Loss
- Trial name
- NCT05708690
- Testing
- Tranexamic Acid 100 MG/ML, normal saline
- Where
- Indonesia
- Volunteers
- 132 people
- Sponsor
- Universitas Indonesia