Clinical trials: Blister
Healthy Volunteers, Abnormal Phagocyte Function
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
This study will investigate the inflammatory response. People with abnormal regulation of inflammation and immune defects often have an exaggerated or depressed inflammatory response that results in poor healing of recurrent…
- Trial name
- NCT00001257
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Inflammation; Skin, Resolution
Pro-Resolving Mediators in Acute Inflammation in Humans
The investigators are undertaking a clinical blister model with or without dietary supplementation with omega-3 fatty acids (i.e., Lovaza) to determine the role of specialized pro-resolving mediators - endogenous lipids converted…
- Conditions
- Inflammation; Skin, Resolution, Blister
- Trial name
- NCT04308889
- Testing
- Lovaza, Cantharone, Phlebotomy
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Skin Pigmentation
Evaluation of a Tranexamoc Acid Treatment on Post-inflammatory Pigmentation in the Suction Blister Model
Post-inflammatory hyperpigmentation (PIH) is a common sequela of inflammatory dermatoses. PIH results from the overproduction of melanin or irregular pigment dispersion after skin inflammation.
- Trial name
- TRANEX (NCT05311033)
- Testing
- Exacyl
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy, Helminthiasis
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering.
- Trial name
- NCT00004996
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis, Autoimmune Blistering Disease
Evaluating the Immune Response to COVID19 Vaccination in Immunodeficient Patients
The purpose of this study is to understand the immune response to coronavirus disease-19 (COVID-19) vaccination in patients on B-cell depleting therapies (BCDT) over time, which in the future may help to inform clinical decision…
- Conditions
- Multiple Sclerosis, Autoimmune Blistering Disease, B-Cell Deficiency
- Trial name
- NCT05286242
- Testing
- COVID19 vaccine
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Yale University
Inflammation
Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrolides
The purpose of this study is to investigate the utility of the cantharidin-induced skin blister assay for evaluation of the anti-inflammatory effects of macrolides in healthy male volunteers.
- Trial name
- NCT01026064
- Testing
- Cantharidin, Azithromycin
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Blister of Foot, Sport Injury
Evaluation of the Effectiveness of the Local Application of Lemon in the Prevention of Blisters in Ultra-trail Runners
For more than a decade, worldwide participation in ultra-marathons and ultra-trails (running races longer than the 42.195 km marathon) has been increasing.
- Trial name
- BS-2 (NCT05086640)
- Testing
- Lemon foot to prevent blister
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Blister, Abrasion
Assessing Foot Injuries in Infantry Recruits Wearing Different Boots
One hundred infantry recruits will be randomly assigned to two groups. Injuries will be monitored.
- Conditions
- Blister, Abrasion, Stress Fracture, Ankle Sprain
- Trial name
- NCT02810002
- Testing
- Experimental infantry boot - DEFINITE-REGULATOR, Control infantry boot
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Dermatitis, Healthy
Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after blister formation.
- Conditions
- Dermatitis, Healthy, Neoplasm, Urticaria
- Trial name
- NCT00001150
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Atopic Dermatitis, Healthy
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals
Cytokine Production Patterns in Patients with Systemic Mastocytosis Compared with Atopic Dermatitis and Healthy Individuals Summary: This study will examine how mast cells (cells involved in allergic reactions) migrate and…
- Conditions
- Atopic Dermatitis, Healthy, Mastocytosis
- Trial name
- NCT00001760
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hyper-Immunoglobulin E. Syndrome (HEIS), Chronic Granulomatous Disease (CGD)
Skin Immunity Sample Collection Involving Blisters and Biopsies
Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections.
- Trial name
- NCT03921515
- Testing
- Blister induction, Skin Biopsies
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Unintentional Ingestion of Prescriptions Within Vials and Blisters
Visual Distraction as a Means of Enhancing Child Resistance
Unintentional poisonings of children continues to be a major issue in the US. According to a study conducted by Cincinnati Children's Hospital Medical Centers, during the period from 2001-2008, emergency room visits for children…
- Trial name
- VDCR (NCT01859780)
- Testing
- Visual distractor
- Where
- 3 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Healthy
Assessment of the Wound Healing Efficacy and Tolerance of a Medical Device on Wounds in Healthy Subjects.
The tested medical device is indicated for the treatment of wounds and small skin injuries. The intention of this study is to evaluate the tolerance and efficacy of the test product by measuring the recovery of the skin barrier…
- Trial name
- NCT04687839
- Testing
- Induction of suction blister, Transepidermal water loss (TEWL), Macrophotography
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
Dermatitis
Characterisation of T-cell Response to Keyhole Limpet Hemocyanin (KLH) and Tuberculin Purified Protein Derivative (PPD)
This is an exploratory study to develop methodologies for the assessment of T-cell mediated therapies via skin immune challenges studies in healthy volunteers.
- Trial name
- NCT01910662
- Testing
- KLH 0.1 mg, KLH 5 mg, PBS (0.1 mL)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dermatitis, Atopic, Asthma
A Study to Evaluate Use of Induced Skin Blisters in Adult Participants With Atopic Dermatitis, Allergic Asthma and Atopic Healthy Participants
The purpose of this study is to characterize the cell (the basic building block of all living things) populations and inflammatory (pain and swelling) mediator responses in suction skin blister fluid after allergic skin reaction…
- Conditions
- Dermatitis, Atopic, Asthma, Healthy
- Trial name
- NCT02343783
- Testing
- Allergic Skin Reaction (ASR) Testing and Skin Blister Induction
- Where
- 7 sites in Belgium, Germany
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Asthma, Bioequivalence
A Bioequivalence Study Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100 mcg/Blister Oral Inhalation Powder /GSK in Healthy Volunteers Under Fasting Conditions
Bioequivalence study between two inhaler products of ffluticasone propionate inhalation powder
- Trial name
- NCT05021887
- Testing
- Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals, FLOVENT DISKUS
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Respirent Pharmaceuticals Co Ltd.
Glaucoma
Effectiveness of a Procedure for Previously Failed Glaucoma Surgery
Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years.
- Trial name
- NCT00347789
- Testing
- Glaucoma surgery- Bleb revision
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Blister
Prevention Trial Assessing Paper-Tape in Endurance Distances (PreTAPED)
Blisters are a very common complaint in both the general population and also the athlete. This study's aim is to determine whether applying paper tape (an inexpensive and common component of most foot care kits) to the foot of…
- Trial name
- NCT01120808
- Testing
- Paper tape
- Where
- 2 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Respiratory Distress Syndrome
Influence of NEP Inhibition on Vascular Leak and Inflammation (NEPi-INFLAMMATION)
Acute Respiratory Distress Syndrome (ARDS) is a severe type of lung injury that affects 10% of patients admitted to Intensive Care Units worldwide, with an unacceptably high mortality of up to 48% in those with the most severe…
- Trial name
- NCT05600062
- Testing
- Racecadotril 100 milligram (MG) Oral Capsule
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London