Clinical trials: Blister
Ruptured Aneurysm of Intracranial Artery
DIVERT: Diversion of Flow in Intracranial VErtebral and Blood Blister-like Ruptured Aneurysms Trial: A Randomized Trial Comparing Pipeline Flow Diversion and Best-Standard-Treatment
The purpose of the DIVERT study is to provide a prudent, controlled clinical context for the use of flow diversion, a promising option of yet unproven benefit, in the care of patients with acute blood blister-like and dissecting…
- Trial name
- DIVERT (NCT01976026)
- Testing
- Flow Diversion, Best Standard Therapy
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Inflammation; Skin, Resolution
Pro-Resolving Mediators in Acute Inflammation in Humans
The investigators are undertaking a clinical blister model with or without dietary supplementation with omega-3 fatty acids (i.e., Lovaza) to determine the role of specialized pro-resolving mediators - endogenous lipids converted…
- Conditions
- Inflammation; Skin, Resolution, Blister
- Trial name
- NCT04308889
- Testing
- Lovaza, Cantharone, Phlebotomy
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Bullous Pemphigoid
Pilot Efficacy and Safety Study of Oral DF2156A in Patients With Active Bullous Pemphigoid
The objective of this clinical trial was to evaluate whether DF2156A has a potential in improving the clinical outcome in patients with active blistering bullous pemphigoid (BP) to warrant its further development.
- Trial name
- NCT01571895
- Testing
- DF2156A
- Where
- 4 sites in Germany, Italy
- Volunteers
- 4 people
- Sponsor
- Dompé Farmaceutici S.p.A
Asthma, Bioequivalence
A Bioequivalence Study Between Fluticasone Propionate 250 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 250 mcg/Blister Oral Inhalation Powder /GSK in Healthy Volunteers Under Fasting Conditions
Bioequivalence study between two inhaler products of ffluticasone propionate inhalation powder
- Trial name
- NCT05397834
- Testing
- Fluticasone Propionate 250 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals, FLOVENT DISKUS
- Where
- Greece
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Respirent Pharmaceuticals Co Ltd.
Asthma, Bioequivalence
A Bioequivalence Study Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100 mcg/Blister Oral Inhalation Powder /GSK in Healthy Volunteers Under Fasting Conditions
Bioequivalence study between two inhaler products of ffluticasone propionate inhalation powder
- Trial name
- NCT05021887
- Testing
- Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals, FLOVENT DISKUS
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Respirent Pharmaceuticals Co Ltd.
Blister
Hydrogel Blister Patch Prototype Treatment for Foot Blisters on the Heel
Study to evaluate the safety and performance of a new blister patch intended to treat blisters on the heel of the foot.
- Trial name
- NCT01088685
- Testing
- Experimental Blister Patch, Marketed Pflaster
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Pneumothorax
Pathogenesis of Primary Spontaneous Pneumothorax
Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax.
- Trial name
- NCT01135004
- Testing
- Thoracoscopic bullectomy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Atherosclerosis
Effect of Darapladib on Cantharidin-Induced Inflammatory Blisters in Subjects With Type 2 Diabetes Mellitus (T2DM)
This will be an exploratory, open-label, single sequence, two part study (Part A and an optional Part B). The aim of this study will be to assess whether systemic inhibition of Lipoprotein associated phospholipase A2 (Lp-PLA2) in…
- Trial name
- NCT02058641
- Testing
- Darapladib
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- GlaxoSmithKline
Hyper-Immunoglobulin E. Syndrome (HEIS), Chronic Granulomatous Disease (CGD)
Skin Immunity Sample Collection Involving Blisters and Biopsies
Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections.
- Trial name
- NCT03921515
- Testing
- Blister induction, Skin Biopsies
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Comparing XEN®-63 Gel Stent and PRESERFLO® MicroShunt
The goal of this randomized controlled clinical trial is to learn whether two minimally invasive bleb-forming glaucoma implants can effectively treat adult patients with open-angle glaucoma who require surgical lowering of…
- Trial name
- MINI-BATTLE (NCT07359547)
- Testing
- XEN®-63 Gel Stent, PRESERFLO™ MicroShunt
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 166 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA)
Lymphatic Anomalies Registry for the Assessment of Outcome Data
Lymphatic anomalies are a rare subset of vascular anomalies that are poorly understood. the understanding of the natural history, long-term outcomes, risk factors for morbidity and mortality, and the relative benefit of medical…
- Conditions
- Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA), Central Conducting Lymphatic Anomaly, CLOVES Syndrome
- Trial name
- NCT02399527
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Blister, Abrasion
Assessing Foot Injuries in Infantry Recruits Wearing Different Boots
One hundred infantry recruits will be randomly assigned to two groups. Injuries will be monitored.
- Conditions
- Blister, Abrasion, Stress Fracture, Ankle Sprain
- Trial name
- NCT02810002
- Testing
- Experimental infantry boot - DEFINITE-REGULATOR, Control infantry boot
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Blister of Foot, Sport Injury
Evaluation of the Effectiveness of the Local Application of Lemon in the Prevention of Blisters in Ultra-trail Runners
For more than a decade, worldwide participation in ultra-marathons and ultra-trails (running races longer than the 42.195 km marathon) has been increasing.
- Trial name
- BS-2 (NCT05086640)
- Testing
- Lemon foot to prevent blister
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Epidermolysis Bullosa Simplex, Epidermolysis Bullosa Simplex Kobner
Using Topical Sirolimus 2% for Patients With Epidermolysis Bullous Simplex (EBS) Study
Epidermolysis bullosa (EB) simplex is a rare orphan disease caused by a mutation in DNA leading to abnormal dominant keratins in the skin.
- Conditions
- Epidermolysis Bullosa Simplex, Epidermolysis Bullosa Simplex Kobner, Weber-Cockayne Syndrome
- Trial name
- NCT02960997
- Testing
- Sirolimus, 2%, Vehicle
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Stanford University
Multiple Myeloma
FCH vs FDG PET/CT in Detection of Lesions in Patients With Multiple Myeloma (MIM)
Hybrid positron emission tomography/computed tomography (PET/CT) has now become available to detect tumors in patients with multiple myeloma.
- Trial name
- MIM (NCT04349358)
- Testing
- FDG and FCH PET/CT
- Where
- 3 sites in France
- Volunteers
- 38 people
- Sponsor
- Centre Georges Francois Leclerc
Glaucoma
Bleb Function and Morphology With Intratendon Injection of MMC Compared With Standard Method
Patients with advanced glaucoma that are candidates for trabeculectomy will be included. Thorough ophthalmic examination including best corrected visual acuity, slit lamp examination, intraocular pressure (IOP) measurement…
- Trial name
- conj mmc (NCT02385370)
- Testing
- MMC
- Where
- Iran
- Volunteers
- 126 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma, Glaucoma Following Surgery
Anterior-segment OCT (AS-OCT) and Intraoperative OCT (iOCT) for Trans- Conjunctival Needle Revision (TCNR)
Trabeculectomy is a very important and commonly performed glaucoma operation. It allows fluid from inside the eye to exit into a space called a bleb located on the surface of the eye under the upper eyelid.
- Trial name
- NCT05790408
- Testing
- Digital microscope integrated with intraoperative OCT (Zeiss Artevo 800, Carl Zeiss Meditec AG), Spectralis Anterior-segment OCT (AS-OCT) (Heidelberg Engineering)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Cardiovascular Diseases, Vesicle
Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration
Extracellular vesicles (EVs) are small vesicles deriving from all cell types during cell activation, involved in transcellular communication, and regarded as predictors of vascular damage and of cardiovascular events.
- Trial name
- NCT05584943
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Glaucoma, Filtering Bleb
Bleb Vascularity and the Outcomes After Trabeculectomy
1. Study objective: To evaluate the relationship between filtering bleb vascularity and the surgical outcomes after trabeculectomy 2.
- Trial name
- NCT04552314
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Multiple Sclerosis, Autoimmune Blistering Disease
Evaluating the Immune Response to COVID19 Vaccination in Immunodeficient Patients
The purpose of this study is to understand the immune response to coronavirus disease-19 (COVID-19) vaccination in patients on B-cell depleting therapies (BCDT) over time, which in the future may help to inform clinical decision…
- Conditions
- Multiple Sclerosis, Autoimmune Blistering Disease, B-Cell Deficiency
- Trial name
- NCT05286242
- Testing
- COVID19 vaccine
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Yale University